Clinical and histopathological characteristics and efficacy of Levocarnitine treatment in canine degenerative myelopathy
Project/Area Number |
23580450
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Clinical veterinary science
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Research Institution | Azabu University |
Principal Investigator |
Saito Miyoko 麻布大学, 獣医学部, 准教授 (80367242)
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Co-Investigator(Kenkyū-buntansha) |
KAMIAHINA Hiroaki 岐阜大学, 応用生物科学部, 准教授 (50506847)
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Co-Investigator(Renkei-kenkyūsha) |
YAMATO Osamu 鹿児島大学, 農水産獣医学域獣医学系, 教授 (80261337)
KATO Shinsuke 鳥取大学, 医学部, 准教授 (60194817)
UCHIDA Kazuyuki 東京大学, 農学生命科学研究科, 准教授 (10223554)
|
Project Period (FY) |
2011-04-28 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | 変性性脊髄症 / ALS / ウェルシュ・コーギー / DMスコア / レボカルニチン / バイオマーカー / 臨床治験 / 犬 / MUNE / 横隔膜 / 呼吸不全 / 超音波検査 / L-カルニチン / SOD1 |
Outline of Final Research Achievements |
Outcome measures for disease progression of degenerative myelopathy (DM) were established through the longitudinal evaluation of Pembroke Welsh Corgis with DM by using the measurements parallel to amyotrophic lateral sclerosis (ALS). MUNE is a promising potential biomarker for ALS and we developed a new technique of MUNE, which is applicable in dogs. Levocarnitine open trial showed safety and efficacy of this medication. Efficacy of levocarnitine was demonstrated by DM score that we developed. These results showed that DM score is useful as a DM functional rating scale and a large-scale clinical trial of levocarnitine is indicated.
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Report
(6 results)
Research Products
(19 results)
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[Journal Article] Genotyping Assays for the Canine Degenerative Myelopathy-Associated c.118G>A (p.E40K) Mutation of the <i>SOD1</i> Gene Using Conventional and Real-Time PCR Methods: A High Prevalence in the Pembroke Welsh Corgi Breed in Japan2013
Author(s)
Chang H.S., Kamishina H., Mizukami K., Momoi Y., Katayama M., Rahman M.M., Uddin M.M., Yabuki A., Kohyama M., Yamato O.
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Journal Title
Journal of Veterinary Medical Science
Volume: 75
Issue: 6
Pages: 795-798
DOI
NAID
ISSN
0916-7250, 1347-7439
Related Report
Peer Reviewed
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[Presentation] イヌの変性性脊髄症における変異型SOD1蛋白凝集体の証明
Author(s)
中前早百合, 漆谷真, 加藤信介, 酒井洋樹, 大和修, 内田和幸, 小川瑞恵, 津久井利広, 鈴木理恵子, 前田貞俊, 神志那弘明
Organizer
第154回日本獣医学会学術集会
Place of Presentation
岩手大学(盛岡市)
Related Report
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