Development of Regio- and Stereoselective Reactions of Polyfunctionalized Molecules by Axially Chiral Catalysts
| Project/Area Number |
23590006
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
FURUTA Takumi 京都大学, 化学研究所, 准教授 (30336656)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 軸性不斉 / 求核触媒 / アシル化 / イオンペア / 非天然アミノ酸 / ロジウムカルボキシラート触媒 / シクロプロパン / 分子認識 / 一般塩基 / 位置選択的反応 / 立体選択的反応 / 一般塩基触媒 |
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| Research Abstract |
Axially chiral catalysts bearing both of the molecular recognition site and the catalytic active site in proper geometry were prepared to approach novel catalytic process, which enables direct regio- and stereoselective transformation of polyfunctionalized molecules.
A biaryl DMAP catalyst with an internal carboxylate, developed in this research, showed high catalytic activity on the acylation of alcohol through activation of the hydroxy group of alcohol by the internal carboxylate ion. On the other hand, an efficient synthetic method for axially chiral amino acids possessing aniline-type amine and carboxylic acid moiety around its chiral axis were also developed. These results provide precious information for developing catalytic regio- and stereoselective transformations of polyfunctionalized molecules.
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Report
(4 results)
Research Products
(60 results)
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[Journal Article] Concise synthesis of catechin probes enabling analysis and imaging of EGCg2011
Author(s)
Yoshida, A.; Hirooka, Y.; Sugata, Y.; Nitta, M.; Manabe, T.; Ido, S.; Murakami, K.; Saha, R. K.; Suzuki, T.; Ohshima, M.; Yoshida, A.; Itoh, K.; Shimizu, K.; Oku, N.; Furuta, T.; Asakawa, T.; Wakimoto, T.; Kan, T.
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Journal Title
Chem. Commun
Volume: 47
Issue: 6
Pages: 1794-1796
DOI
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[Patent(Industrial Property Rights)] 酸化触媒2011
Inventor(s)
川端猛夫、浜田翔平、古田 巧
Industrial Property Rights Holder
京都大学法人
Industrial Property Rights Type
特許
Industrial Property Number
2011-167425
Filing Date
2011-07-29
Related Report
Overseas
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