Development of novel triterprnoids as a drug candidate that prevent and/or cure for metabolic syndrome related disease.
| Project/Area Number |
23590010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Sojo University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | メタボリックシンドローム / トリテルペン / マクロファージ / 泡沫化抑制 / ursolic acid / トリテルペノイド / 泡沫化抑制成分 / 泡沫化 / マクロファージ泡沫化抑制 |
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| Research Abstract |
It was observed that corosolic acid from residue of apple juice and tubocaposides from the fruit of Tubocapsicum anomalum inhibited the accumulation of triglyceride in adipocyte cell. Tomatidine, which is an aglycone part of tomatine obtained from areal part of Solanum lycopersicum, and pomolic acid isolated from the fruit of Ziziphus jujube suppressed the macrophage foam cell formation. To compare bioactivity, 3-hydroxyl group and 28-carboxylic acid group of ursolic acid was modified. This experiment showed that 28-carboxylic acid group was crucial part to inhibit the macrophage foam cell formation. On the other hands, six triterpenoids having carboxylic acid group were isolated from antler-shaped fruiting body of Ganoderma lucidum. Now these compounds are prepared to examine on foam cell formation in vitro.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Tomatidine, a Tomato Sapogenol, Ameliorates Hyperlipidemia and Atherosclerosis in ApoE-Deficient Mice by Inhibiting Acyl-CoA : cholesterol Acyl- transferase (ACAT)2012
Author(s)
Fujiwara Yukio, Kiyota Naoko, Tsurushima Keiichiro, Yoshitomi Makiko, Horlad Hasita, Ikeda Tsuyoshi, Nohara Toshihiro, Takeya Motohiro, Nagai Ryoji
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Journal Title
J. Agri. Food Chem
Volume: 60 (10)
Issue: 10
Pages: 2472-2479
DOI
Related Report
Peer Reviewed
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[Journal Article] Garlicnins B<sub>1</sub>, C<sub>1</sub>, and D, from the Fraction Regulating Macrophage Activation of <i>Allium sativum</i>2012
Author(s)
Nohara, Toshihiro; Kiyota, Yuka; Sakamoto, Toyonobu; Manabe, Hideyuki; Ono, Masateru; Ikeda, Tsuyoshi; Fujiwara, Yukio; Nakano, Daisuke; Kinjo, Junei
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Journal Title
Chemical and Pharmaceutical Bulletin
Volume: 60
Issue: 6
Pages: 747-751
DOI
NAID
ISSN
0009-2363, 1347-5223
Related Report
Peer Reviewed
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[Journal Article] Lucidenic acids-rich extract from antlered form of Ganoderma lucidum enhances TNFαinduction in THP-1 monocytic cells possibly via its modulation of MAP kinases p38 and JNK2011
Author(s)
Watanabe Kenji, Shuto Tsuyoshi, Sato Miki, Onuki Kouhei, Mizunoe Shota, Suzuki Shingo, Sato Takashi, Koga Tomoaki, Suico Mary Ann, Kai Hirofumi, Ikeda Tsuyoshi
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Journal Title
Biochem. Biophys. Res. Comm
Volume: 408 (1)
Issue: 1
Pages: 18-24
DOI
Related Report
Peer Reviewed
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