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Development of novel triterprnoids as a drug candidate that prevent and/or cure for metabolic syndrome related disease.

Research Project

Project/Area Number 23590010
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Chemical pharmacy
Research InstitutionSojo University

Principal Investigator

IKEDA Tsuyoshi  崇城大学, 薬学部, 准教授 (80295138)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsメタボリックシンドローム / トリテルペン / マクロファージ / 泡沫化抑制 / ursolic acid / トリテルペノイド / 泡沫化抑制成分 / 泡沫化 / マクロファージ泡沫化抑制
Research Abstract

It was observed that corosolic acid from residue of apple juice and tubocaposides from the fruit of Tubocapsicum anomalum inhibited the accumulation of triglyceride in adipocyte cell. Tomatidine, which is an aglycone part of tomatine obtained from areal part of Solanum lycopersicum, and pomolic acid isolated from the fruit of Ziziphus jujube suppressed the macrophage foam cell formation. To compare bioactivity, 3-hydroxyl group and 28-carboxylic acid group of ursolic acid was modified. This experiment showed that 28-carboxylic acid group was crucial part to inhibit the macrophage foam cell formation. On the other hands, six triterpenoids having carboxylic acid group were isolated from antler-shaped fruiting body of Ganoderma lucidum. Now these compounds are prepared to examine on foam cell formation in vitro.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (27 results)

All 2014 2013 2012 2011 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (12 results) Book (4 results)

  • [Journal Article] Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling2013

    • Author(s)
      Fujiwara Yukio, Takaishi Kiyomi, Nakao Junko, Ikeda Tsuyoshi, Katabuchi Hidetaka, Takeya Motohiro, Komohara Yoshihiro
    • Journal Title

      Oncology Letters

      Volume: 6 (6) Issue: 6 Pages: 1619-1623

    • DOI

      10.3892/ol.2013.1591

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Corosolic acid impairs tumor development and lung metastasis by inhibiting the immunosuppressive activity of myeloid-derived suppressor cells2013

    • Author(s)
      Horlad Hasita, Fujiwara Yukio, Takemura Kenichi, Ohnishi Koji, Ikeda Tsuyoshi, Tsukamoto Hirotake, Mizuta Hiroshi, Nishimura Yasuharu, Takeya Motohiro, Komohara Yoshihiro
    • Journal Title

      Mol. Nutri. Food Res

      Volume: 57 (6) Issue: 6 Pages: 1-9

    • DOI

      10.1002/mnfr.201200610

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Saponins Esculeosides B-1 and B-2 in Italian Canned Tomatoes2013

    • Author(s)
      Manabe Hideyuki; Fujiwara Yukio; Ikeda Tsuyoshi; Ono Masateru; Murakami Kotaro; Zhou Jian-Rong; Yokomizo Kazumi; Nohara Toshihiro
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 61 Issue: 7 Pages: 764-767

    • DOI

      10.1248/cpb.c13-00202

    • NAID

      130003360799

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclic Sulfoxides Garlicnins B<sub>2</sub>, B<sub>3</sub>, B<sub>4</sub>, C<sub>2</sub>, and C<sub>3</sub> from <i>Allium sativum</i>2013

    • Author(s)
      Nohara Toshihiro; Fujiwara Yukio; Ikeda Tsuyoshi; Murakami Kohtaro; Ono Masateru; Nakano Daisuke; Kinjo Junei
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 61 Issue: 7 Pages: 695-699

    • DOI

      10.1248/cpb.c13-00082

    • NAID

      130003360797

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Purification and characterization of HSP-inducers from Eupatorium lindleyanum2012

    • Author(s)
      Yamashita Yasuhiro, Ikeda Tsuyoshi, Matsuda Minoru, Maji Daisuke, Hoshino Tatsuya, Mizushima Tohru
    • Journal Title

      Biochem. Pharmacol

      Volume: 83 (7) Issue: 7 Pages: 909-922

    • DOI

      10.1016/j.bcp.2011.12.040

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tomatidine, a Tomato Sapogenol, Ameliorates Hyperlipidemia and Atherosclerosis in ApoE-Deficient Mice by Inhibiting Acyl-CoA : cholesterol Acyl- transferase (ACAT)2012

    • Author(s)
      Fujiwara Yukio, Kiyota Naoko, Tsurushima Keiichiro, Yoshitomi Makiko, Horlad Hasita, Ikeda Tsuyoshi, Nohara Toshihiro, Takeya Motohiro, Nagai Ryoji
    • Journal Title

      J. Agri. Food Chem

      Volume: 60 (10) Issue: 10 Pages: 2472-2479

    • DOI

      10.1021/jf204197r

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Garlicnins B<sub>1</sub>, C<sub>1</sub>, and D, from the Fraction Regulating Macrophage Activation of <i>Allium sativum</i>2012

    • Author(s)
      Nohara, Toshihiro; Kiyota, Yuka; Sakamoto, Toyonobu; Manabe, Hideyuki; Ono, Masateru; Ikeda, Tsuyoshi; Fujiwara, Yukio; Nakano, Daisuke; Kinjo, Junei
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 60 Issue: 6 Pages: 747-751

    • DOI

      10.1248/cpb.60.747

    • NAID

      130001852475

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Triterpenes Isolated from Zizyphus Jujuba Inhibit the Foam Cell Formation in Macrophages2011

    • Author(s)
      Y.Fujiwara, et al
    • Journal Title

      J.Agric.Food Chem.

      Volume: 59 Issue: 9 Pages: 4544-4552

    • DOI

      10.1021/jf200193r

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lucidenic acids-rich extract from antlered form of Ganoderma lucidum enhances TNFαinduction in THP-1 monocytic cells possibly via its modulation of MAP kinases p38 and JNK2011

    • Author(s)
      Watanabe Kenji, Shuto Tsuyoshi, Sato Miki, Onuki Kouhei, Mizunoe Shota, Suzuki Shingo, Sato Takashi, Koga Tomoaki, Suico Mary Ann, Kai Hirofumi, Ikeda Tsuyoshi
    • Journal Title

      Biochem. Biophys. Res. Comm

      Volume: 408 (1) Issue: 1 Pages: 18-24

    • DOI

      10.1016/j.bbrc.2011.03.108

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anti-obesity Compounds in Green Leaves of Eucommia ulmoides2011

    • Author(s)
      T.Hirata, et al
    • Journal Title

      Bioorg.Med.Chem.Lett.

      Volume: 21 Issue: 6 Pages: 1786-1791

    • DOI

      10.1016/j.bmcl.2011.01.060

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Oleanolic acid inhibits macrophage differentiation into the M2 phenotype and glioblastoma cell proliferation by suppressing the activation of STAT32011

    • Author(s)
      Fujiwara Y., Komohara Y., Kudo R., Tsurushima K., Ohnishi K., Ikeda T., Takeya M.,
    • Journal Title

      Oncology Reports

      Volume: 26 Pages: 1533-1537

    • DOI

      10.3892/or.2011.1454

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 生薬イカリソウのAGEs生成阻害物質の探索研究:プレニルフラボノイドの立体化学の検討2014

    • Author(s)
      池田剛, 他
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本市立体育館
    • Year and Date
      2014-03-29
    • Related Report
      2013 Final Research Report
  • [Presentation] イカリソウのAGEs生成阻害成分の探索研究2013

    • Author(s)
      池田剛, 他
    • Organizer
      日本生薬学会第60回年会
    • Place of Presentation
      北海道医療大学
    • Year and Date
      2013-09-08
    • Related Report
      2013 Final Research Report
  • [Presentation] AGEs生成阻害物質の探索研究:イカリソウのCMA阻害活性について2013

    • Author(s)
      池田剛, 他
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2013-03-29
    • Related Report
      2013 Final Research Report
  • [Presentation] AGEs生成阻害物質の探索研究:シャクヤクのCMA阻害活性成分について2012

    • Author(s)
      池田剛, 他
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学
    • Year and Date
      2012-03-29
    • Related Report
      2013 Final Research Report
  • [Presentation] AGEs 生成阻害物質の探索研究:シャクヤクの CMA 生成阻害活性成分について(2)2012

    • Author(s)
      鈴木将弘、吉冨万希子、藤原章雄、永井竜児、塚本佐知子、池田 剛
    • Organizer
      日本薬学会第132年会(札幌)
    • Place of Presentation
      北海道大学
    • Related Report
      2011 Research-status Report
  • [Presentation] トマチン糖鎖誘導体の合成に関する研究2011

    • Author(s)
      井村優介、塚本佐知子、池田 剛
    • Organizer
      日本生薬学会第58回年会(東京)
    • Place of Presentation
      昭和大学薬学部
    • Related Report
      2011 Research-status Report
  • [Presentation] 生薬イカリソウのAGEs生成阻害物質の探索研究:プレニルフラボノイドの立体化学の検討

    • Author(s)
      中嶋圭介、宮下裕幸、吉満 斉、藤原章雄、永井竜児、池田 剛
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本県熊本市 熊本市立体育館
    • Related Report
      2013 Annual Research Report
  • [Presentation] Allium Sulfides (25) Garlicnin C の抗腫瘍活性と新規化合物

    • Author(s)
      野原稔弘、藤原章雄、真鍋秀雪、池田 剛、小野政輝、村上光太郎
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本県熊本市 熊本大学黒髪キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] トマトサポニンに関する研究 トマトサポニンのプレグナンへの変換反応

    • Author(s)
      野原稔弘、藤原章雄、真鍋秀雪、池田 剛、村上光太郎、小野政輝、中野大輔、金城順英、梶本哲也
    • Organizer
      日本生薬学会第60回年会
    • Place of Presentation
      北海道石狩郡当別町 北海道医療大学薬学部
    • Related Report
      2013 Annual Research Report
  • [Presentation] イカリソウのAGEs生成阻害成分の探索研究

    • Author(s)
      中嶋圭介、宮下裕幸、吉満 斉、藤原章雄、永井竜児、池田 剛
    • Organizer
      日本生薬学会第60回年会
    • Place of Presentation
      北海道石狩郡当別町 北海道医療大学薬学部
    • Related Report
      2013 Annual Research Report
  • [Presentation] AGEs生成阻害物質の探索研究:イカリソウのCMA阻害活性成分について

    • Author(s)
      池田 剛、中嶋圭介、宮下裕幸、吉満 斉、藤原章雄、永井竜児
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] トマトサポニンの研究

    • Author(s)
      野原稔弘、真鍋秀雪、池田 剛、村上光太郎、小野政輝
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Book] Study in Natural Product Chemistry2013

    • Author(s)
      Tetsuya Hirata, Tsuyoshi Ikeda, Takahiko Fujikawa, Sansei Nishibe
    • Total Pages
      518
    • Publisher
      Elsevier社
    • Related Report
      2013 Final Research Report
  • [Book] 機能性配糖体の合成と応用2013

    • Author(s)
      池田剛
    • Total Pages
      212
    • Publisher
      シーエムシー出版
    • Related Report
      2013 Final Research Report
  • [Book] 機能性配糖体の合成と応用2013

    • Author(s)
      池田 剛
    • Total Pages
      212
    • Publisher
      シーエムシー出版
    • Related Report
      2013 Annual Research Report
  • [Book] Studies in Natural Products Chemistry2013

    • Author(s)
      Tetsuya Hirata, Tsuyoshi Ikeda, Takahiko Fujikawa,and Sansei Nishibe
    • Total Pages
      518
    • Publisher
      Elsevier
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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