| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
A new method was established for the preparation of trans-4,5-dimethoxy-2-imidazolidinone (DMIm), versatile chiral synthon for the preparation of various optically active 1,2-diamines which were very useful in the field of pharmaceutical and/or agrochemical science, via the Fe(III)-catalyzed oxidation of 2-imidazolone by H2O2-urea followed by the subsequent optical resolution via the introduction of a MAC moiety. Chiral DMIm was also available from highly diastereoselective Fe-catalyzed oxidation of chiral 2-imidazolone. Enantioselective oxidation of trans-stilbene catalyzed by chiral "roofed" cis-1,2-diamine-iron complex was tried and moderate enantioselectivity was achieved.
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