| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Taxol is a taxane diterpenoid, which shows cytotoxic activity against leukemia cells and inhibitory action against a variety of tumors. It has been recognized as one of the most effective and widely used drugs for the treatment of ovarian, breast, and lung cancers. Despite its effective pharmacological activities, taxol has shortcomings such as low solubility in water. To date, a number of taxol derivatives have been designed and chemically prepared in order to enhance its water-solubility. Saccharide conjugation drastically enhances the water-solubility of aglycones. We synthesized highly water-soluble monosaccharide conjugates of taxol by chemo-enzymatic procedures.
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