Synthesis of highly water-soluble taxol derivatives
| Project/Area Number |
23590013
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | Oita University |
|---|
Principal Investigator |
Shimoda Kei 大分大学, 医学部, 准教授 (40284153)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
HAMADA Hiroki 岡山理科大学, 理学部, 教授 (10164914)
|
|---|
| Project Period (FY) |
2011-04-28 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | タキソール / 誘導体 / 合成 / 有機合成 / 酵素 / 生体触媒 |
|---|
| Outline of Final Research Achievements |
Taxol is a taxane diterpenoid, which shows cytotoxic activity against leukemia cells and inhibitory action against a variety of tumors. It has been recognized as one of the most effective and widely used drugs for the treatment of ovarian, breast, and lung cancers. Despite its effective pharmacological activities, taxol has shortcomings such as low solubility in water. To date, a number of taxol derivatives have been designed and chemically prepared in order to enhance its water-solubility. Saccharide conjugation drastically enhances the water-solubility of aglycones. We synthesized highly water-soluble monosaccharide conjugates of taxol by chemo-enzymatic procedures.
|
Report
(6 results)
Research Products
(10 results)
-
-
[Journal Article] Synthesis of glycosides of resveratrol, pterostilbene, and piceatannol, and their anti-oxidant, anti-allergic, and neuroprotective activities.2014
Author(s)
D. Sato, N. Shimizu, Y. Shimizu, M. Akagi, Y. Eshita, S. Ozaki, N. Nakajima, K. Ishihara, N. Masuoka, H. Hamada, K. Shimoda, N. Kubota
-
Journal Title
Bioscience, Biotechnology, and Biochemistry
Volume: 78
Pages: 1123-1128
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
