| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Outline of Final Research Achievements |
Toward synthetic study towards antitumor antibiotic lomaiviticin A with dimeric structure, the synthesis of the substrate for the dimerization was explored, which has a structurally flexible 2-aryl cyclohexane derivative before the construction of 5-membered B-ring with suitable solubility for dimerization condition. Substrate for the dimerization was obtained with Suzuki coupling of bromocyclohexenone and Nagata reagent but dimerization at a desired position was not observed. On the other hand, D ring construction from cinnamic acid ester and furanone was achieved by Michael-Dieckmann continuous reaction.
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