Synthetic study toward lomaiviticin A with dimerization of the substrate with flexible structure
| Project/Area Number |
23590018
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Musashino University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | ロマイチビチン / 抗生物質 / 抗腫瘍活性 / Michael 反応 / Dieckmann 縮合 / 二量化反応 / 鈴木-宮浦カップリング / ロマイビチシン / 二量化 / Michael-Dieckman 連続反応 / Diels-Alder 反応 / 鈴木－宮浦カップリング / ２量化反応 |
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| Outline of Final Research Achievements |
Toward synthetic study towards antitumor antibiotic lomaiviticin A with dimeric structure, the synthesis of the substrate for the dimerization was explored, which has a structurally flexible 2-aryl cyclohexane derivative before the construction of 5-membered B-ring with suitable solubility for dimerization condition. Substrate for the dimerization was obtained with Suzuki coupling of bromocyclohexenone and Nagata reagent but dimerization at a desired position was not observed. On the other hand, D ring construction from cinnamic acid ester and furanone was achieved by Michael-Dieckmann continuous reaction.
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Report
(5 results)
Research Products
(6 results)
