| Project/Area Number |
23590019
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Meiji Pharmaceutical University |
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Principal Investigator |
SAITO NAOKI 明治薬科大学, 薬学部, 教授 (80142545)
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| Co-Investigator(Kenkyū-buntansha) |
YOKOYA Masashi 明治薬科大学, 薬学部, 助教 (50338539)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 海洋天然物 / 抗腫瘍活性 / イソキノリン / 国際共同研究 / 構造解析 / 全合成 / エクチナサイジン / レニエラマイシン / 制癌剤 / 合成 / 構造活性相関 / 国際情報交換 / 構造決定 / タイ / フィリピン / 国際情報交流 / タイ王国 |
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| Research Abstract |
In the course of our research on new metabolites, which involves the isolation and characterization of biologically active compounds and the preparation of their respective alnalogues, we can isolate several new marine isoquinolines, such as renieramycin V-Y from blue sponges. The second, we are succeeded to the total syntheses of renieramycin G and cribrstatin 4. Furthermore, many model compounds of the left half of renieramycins were prepared from phenylalanine derivatives. The initial cytotoxicity profiles of natural products and their derivatives along with synthetic analogues are also presented.
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