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Development for medicinal chemistry on antitumor isoquinoline marine natural products as lead compound

Research Project

Project/Area Number 23590019
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Chemical pharmacy
Research InstitutionMeiji Pharmaceutical University

Principal Investigator

SAITO NAOKI  明治薬科大学, 薬学部, 教授 (80142545)

Co-Investigator(Kenkyū-buntansha) YOKOYA Masashi  明治薬科大学, 薬学部, 助教 (50338539)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords海洋天然物 / 抗腫瘍活性 / イソキノリン / 国際共同研究 / 構造解析 / 全合成 / エクチナサイジン / レニエラマイシン / 制癌剤 / 合成 / 構造活性相関 / 国際情報交換 / 構造決定 / タイ / フィリピン / 国際情報交流 / タイ王国
Research Abstract

In the course of our research on new metabolites, which involves the isolation and characterization of biologically active compounds and the preparation of their respective alnalogues, we can isolate several new marine isoquinolines, such as renieramycin V-Y from blue sponges. The second, we are succeeded to the total syntheses of renieramycin G and cribrstatin 4. Furthermore, many model compounds of the left half of renieramycins were prepared from phenylalanine derivatives. The initial cytotoxicity profiles of natural products and their derivatives along with synthetic analogues are also presented.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (68 results)

All 2014 2013 2012 2011 Other

All Journal Article (24 results) (of which Peer Reviewed: 23 results) Presentation (41 results) (of which Invited: 2 results) Remarks (3 results)

  • [Journal Article] Isolation, structure characterization, and synthesis of stabilized 1,2,3,4-tetrahydroisoquinline marine natural product from pretreated Thai tunicate Ecteinascidia thrstoni with potassium cyanide2014

    • Author(s)
      Kimura S., Pangkruang W., Yokoya M., Honda A., Puthongking P., Suwanborirux K., Saito N.
    • Journal Title

      Heterocycles

      Volume: 88 (1) Issue: 1 Pages: 363-375

    • DOI

      10.3987/com-13-s(s)32

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chemistry of Ecteinascidins. Part 4. Preparation of 2'-N-Acyl Ecteinascidin 770 Derivatives with Improved Cytotoxicity Profiles2013

    • Author(s)
      Mitsuhiro Tsujimoto, Witaya Lowtangkitcharoen, Nanae Mori, Waree Pangkruang, Ploenthip Puthongking, Khanit Suwanborirux, Naoki Saito
    • Journal Title

      Chem Pharm. Bull

      Volume: 61 Pages: 1052-1064

    • NAID

      130004137252

    • URL

      https://www.jstage.jst.go.jp/article/cpb/61/10/61_c13-00525/_pdf

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Replacement of a Quinone by 5-O-Acetylhydroquinone Abolishes the Accidental Necrosis Inducing Effect While Preserving theApoptosis-Inducing Effect of Renieramycin M on Lung Cancer Cells2013

    • Author(s)
      Thaniwan Cheun-Arom, Pithi Chanvorachote, Natchanun Sirimangkalakitti, Takushina Chuanasa, Naoki Saito, Ikuo Abe, Khanit Suwanborirux
    • Journal Title

      J. Nat. Prod

      Volume: 76 Pages: 1468-1474

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of Tricyclic Lactam Model Compounds of Renieramycin and Saframycin Anticancer natural Products from Common Intermediate2013

    • Author(s)
      Keiyo Nakai, Masashi Yokoya, Naoki Saito
    • Journal Title

      Chem. Pharm. Bull

      Volume: 61 Pages: 853-869

    • NAID

      130003360817

    • URL

      https://www.jstage.jst.go.jp/article/cpb/61/8/61_c13-00361/_pdf

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ecteinascidin 770, a Tetrahydroisoquinoline Alkaloid, Sensitizees human lung Cancer Cells to Anoikis2013

    • Author(s)
      Phattrakorn Powan, Naoki Saito, Khanit Suwanborirux, Pithi Chanvorachote
    • Journal Title

      Anticancer Res

      Volume: 33 Pages: 505-512

    • URL

      http://ar.iiarjournals.org/content/33/2/505.full.pdf+html

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preparation of tricyclic lactam model compounds of renieramycin and saframycin anticancer natural products from common intermediate2013

    • Author(s)
      Nakai K., Yokoya M., Saito N.
    • Journal Title

      Chem. Pharm. Bull.

      Volume: 61(8) Pages: 853-869

    • NAID

      130003360817

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pepracement of a quinone by a 5-O-acetylhydroquinone abolishes accididental necrosis-inducing effect while preserving apoptosis-inducing effect to renieramycin M in lung cancer cells2013

    • Author(s)
      Cheun-Arom T., Chanvorachote P., Sitimangkalkakitti N., Chuanasa T., Saito N., Abe I., Suwanborirux K.
    • Journal Title

      J. Nat. Prod.

      Volume: 76 Issue: 8 Pages: 1468-1474

    • DOI

      10.1021/np400277m

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemistry of ecteinascidins. Part 4. Preparation of 2'-N-acyl ecteinascidin 770 analogues with improved cytotoxicity profiles2013

    • Author(s)
      Tsujimoto M., Lowtangkitcharoen W., Mori N., Pangkruang W., Puthongking P., Suwanborirux K., Saito N.
    • Journal Title

      Chem. Pharm. Bull.

      Volume: 61(10) Pages: 1052-1064

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ecteinasicin 770, a tetrahydroisoquinoline alkaloid, sensitized human lung cancer celss to anokis2013

    • Author(s)
      Powan P., Saito N., Suwanborirux K., Chanvorachote P.
    • Journal Title

      Anticancer Res

      Volume: 33 Pages: 505-512

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article]2012

    • Author(s)
      Mari Tatsukawa, Louvy Lynn C.Punzalan,Hilbert D. S. Magpantay, Irene M. Villasenñr, Gisela P. Concepcion, Khanit Suwanborirux, Masashi Yokoya, Naoki Saito
    • Journal Title

      Tetrahedron

      Volume: 68 Issue: 36 Pages: 7422-7428

    • DOI

      10.1016/j.tet.2012.06.067

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selenium oxide oxidation of hexahydro-1,5-imino-3-benzazocine-7,10-dione in aliphatic alcohol for conversion of renieramycin marine natural product2012

    • Author(s)
      Mori M., Daikuhara N., Yamada J., Saito N.
    • Journal Title

      Heterocycles

      Volume: 86 Issue: 1 Pages: 317-330

    • DOI

      10.3987/com-12-s(n)12

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chemistry of Renieramycins. Part 12. An Improved Total Synthesis of (±)-Renieramycin G2012

    • Author(s)
      Masashi Yokoya, Kimiko Shinada-Fujino, Saiko Masahiro Mimura, Yoshida, Hiroki Takada, Naoki Saito
    • Journal Title

      Tetrahedron

      Volume: 68 Issue: 22 Pages: 4166-4181

    • DOI

      10.1016/j.tet.2012.03.105

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular networkprofiling of U373MG human glioblastomacells following induction of apoptosis bynovel marine-derived anti-cancer1,2,3,4-tetrahydroisoquinoline alkaloids.2012

    • Author(s)
      Tabunoki H, Saito N, Suwanborirux K,Charupant K, Satoh J.
    • Journal Title

      Cancer Cell International

      Volume: 12(1) Issue: 1 Pages: 1-14

    • DOI

      10.1186/1475-2867-12-14

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chemistry of Renieramycins. Part 10. Structure of Renieramycin V, A Novel Renieramycin Marine Natural Product Having a Sterol Ether at C-14 position2012

    • Author(s)
      Naoki Saito, Miho Yoshino, Kornvika Charupant, Khanit Suwanborirux
    • Journal Title

      Heterocycles

      Volume: 84 Issue: 1 Pages: 309-314

    • DOI

      10.3987/com-11-s(p)28

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Molecular network profiling of U373MG human glioblastoma cells-following induction of apoptosis by novel marine derived anti-cancer 1,2,3,4-tetrahydroisoquinoline alkaloids2012

    • Author(s)
      Tabunoki H., Saito N., Suwanborirux K., Charupant K., Satoh J.
    • Journal Title

      Cncer Cell International

      Volume: 12/14 Pages: 1-14

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chemistry of renieramycins. Part 12. An inproved total synthesis of (;/-)-renieramycin G2012

    • Author(s)
      Yokoya M., Shinada-Fujino K., Yoshida S., Mimura M., Takada H., Saito N.
    • Journal Title

      Tetrahedron

      Volume: 68 Pages: 4166-4181

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chemistry of renieramycins. Part 13. Isolation and structure of stabilized renieramycin type derivatives, renieramycins W-Y, from Philippine blue sponge Xestospongia sp., pretreated with potassium cyanide2012

    • Author(s)
      Tatsukawa M., Punzalan LL., Magpantay H. D. S., Villasenor I. M., Concepcion G. P., Suwanborirux K., Yokoya M., Saito N.
    • Journal Title

      Tetrahedron

      Volume: 68 Pages: 7422-7428

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chemistry of Renieramycins. Part 11. Total Synthesis of (±)-Cribrostatin 42011

    • Author(s)
      Masashi Yokoya, Hiroshi Ito, Naoki Saito
    • Journal Title

      Tetrahedron

      Volume: 67 Issue: 47 Pages: 9185-9192

    • DOI

      10.1016/j.tet.2011.09.076

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chemistry of Ecteinascidins. Part 3. Preparation of 2'-N-Acyl Derivatives of Ecteinascidin 770 and Evaluation of Cytotoxicity2011

    • Author(s)
      Panithi Saktrakulkula, Satoru Toriumi, Masahiro Tsujimoto, Chamunan Patarapanich, Khanit Suwanborirux, Naoki Saito
    • Journal Title

      Bioorg. & Med. Chem

      Volume: 19 Pages: 4421-4436

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of Renieramycins. Construction of the Core Ring System of Cribrostatin 4 Trough Modified Pictet-Spengler Cyclization of 3,6-Bisarylpiperazine-2,5-Dione with Diethoxyethyl Benzoate2011

    • Author(s)
      Masashi Yokoya, Hiroshi Ito, Naoki Saito
    • Journal Title

      Chem. Pharm. Bull

      Volume: 59 Pages: 787-792

    • URL

      https://www.jstage.jst.go.jp/article/cpb/59/6/59_6_787/_pdf

    • Related Report
      2013 Final Research Report
  • [Journal Article] Chemistry of Renieramycins. Part 9. Stereocontrolled Total Synthesis of (±)-Renieramycin G2011

    • Author(s)
      Masashi Yokoya, Kimiko Shinada-Fujino, Naoki Saito
    • Journal Title

      Tetrahedron Lett

      Volume: 52 Pages: 2446-2449

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chemistry of renieramycins. Part 9: Stereo-2011

    • Author(s)
      Yokoya M., Shinada-Fujino K., Saito N.
    • Journal Title

      Tetrahedron Letters

      Volume: 52 Pages: 2446-2449

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synthesis of renieramycins: construction of2011

    • Author(s)
      Yokoya M., Ito H., Saito N.
    • Journal Title

      Chem. Pharm. Bull.

      Volume: 59 Pages: 787-792

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chemistry of ecteinascidins. Part 3. Prep-2011

    • Author(s)
      Saktrakulkla P., Toriumi S., et al.
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 19 Issue: 15 Pages: 4421-4436

    • DOI

      10.1016/j.bmc.2011.06.047

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] エクチナサイジン海洋天然物の化学修飾と生物活性評価2014

    • Author(s)
      森ななえ、辻本光宏、Witaya Lowtangkitcharoen, Khanit Suwanborirux, 齋藤直樹
    • Organizer
      日本薬学会第134 年会
    • Place of Presentation
      熊本
    • Year and Date
      2014-03-29
    • Related Report
      2013 Final Research Report
  • [Presentation] レニエラマイシン右半部モデル化合物の合成と生物活性評価2014

    • Author(s)
      中井啓陽、久保圭司、横屋正志、齋藤直樹
    • Organizer
      日本薬学会第134 年会
    • Place of Presentation
      熊本
    • Year and Date
      2014-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] レニエラマイシンMの右半部モデル化合物の合成と生物活性評価2014

    • Author(s)
      中井啓陽、久保佳司、横屋正志、齋藤直樹
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] サフラマイシンAの合成(その2)2014

    • Author(s)
      河合慎太郎、東雅之、木村真也、横屋正志、齋藤直樹
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] エクチナサイジン海洋天然物の化学的研究:天然物の化学修飾と生物活性評価2014

    • Author(s)
      森ななえ、辻本光宏、Witaya Lowtangkitcharoen, Khanit Suwanborirux, 齋藤直樹
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] レニエラマイシン系海洋天然物の探索研究:期限海洋生物の生息地と二次代謝産物の比較2014

    • Author(s)
      平出裕美、平松亜依、Louvy L. C. Punzalan, Gisela P. Concepcion, Natchanun Sirimankalakitti, Khanit Suwanborirux, 齋藤直樹
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 新規抗腫瘍活性海洋天然物レニエラマイシンTの全合成研究(22014

    • Author(s)
      木村真也、齋藤直樹
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 海洋天然物クリブロスタチン4の基本骨格形成反応の機構会計に向けた化学的研究2014

    • Author(s)
      小林恵一郎、伊東裕史、横屋正志、齋藤直樹
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 抗腫瘍活性テトラヒドロイソキノリン天然物の合成―共通中間体から左半部モデル化合物の合成2013

    • Author(s)
      中井啓陽、久保圭司、中山梨乃、横屋正志、齋藤直樹
    • Organizer
      第39回反応と合成の進歩シンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2013-11-05
    • Related Report
      2013 Final Research Report
  • [Presentation] タイ国に生息する海洋生物由来アルカロイドを創薬リードとする化学的研究2013

    • Author(s)
      齋藤直樹
    • Organizer
      第57回日本薬学会関東支部大会
    • Place of Presentation
      東京
    • Year and Date
      2013-10-26
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Chemistry of Ecteinascidin Marine Natural Products. Preparation of 2'-N-Acyl Derivatives of Ecteinascidin 770 and Evaluation of Cytotoxicity2013

    • Author(s)
      Naoki Saito, Mitsuhiko Tsujimoto, Nanae Mori, Waree Pangkruang, Proenthip Puthongking, Witaya Lowtangkitcharoen, Khanit Suwanborirux
    • Organizer
      The 9^<th> FMC International Chemistry Symposium (AIMECS13)
    • Place of Presentation
      Taipei (Taiwan)
    • Year and Date
      2013-10-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 抗腫瘍活性天然物レニエラマイシンM の全合成2013

    • Author(s)
      高田裕樹、三村政博、横屋正志、齋藤直樹
    • Organizer
      日本薬学会第133 年会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-29
    • Related Report
      2013 Final Research Report
  • [Presentation] タイ国に生息する海洋生物由来アルカロイドを創薬リードとする化学的研究2013

    • Author(s)
      齋藤直樹
    • Organizer
      第57回日本薬学会関東支部大会
    • Place of Presentation
      帝京大学薬学部(東京)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] タイの群体ホヤ由来1,2,3,4-テトラヒドロイソキノリン海洋天然物の単利・構造決定および合成2013

    • Author(s)
      木村真也、Waree Pangkruang, 横屋正志、本田遍、Ploenthip Puthongking, Khanit Suwanborirux, 齋藤直樹
    • Organizer
      第57回日本薬学会関東支部大会
    • Place of Presentation
      帝京大学薬学部(東京)
    • Related Report
      2013 Annual Research Report
  • [Presentation] タイ国に生息する群体ホヤ由来エクチナサイジン海洋天然物の抗腫瘍活性増強を目指した合成研究2013

    • Author(s)
      森ななえ、辻本光宏、ビタヤ・ロタンチャローン、カニ・スワンボリラックス、齋藤直樹
    • Organizer
      第3回CSJ化学フェスタ
    • Place of Presentation
      船堀(東京)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 抗腫瘍活性テトラヒドロイソキノリン天然物の合成ー共通中間体から左半部モデル化合物の合成2013

    • Author(s)
      中井啓陽、久保佳司、中山梨乃、横屋正志、齋藤直樹
    • Organizer
      第39回反応と合成の進歩シンポジウム
    • Place of Presentation
      九州大学(博多)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Chemistry of Ecteinascidin Marine Natural Products: Preparation of 2'-N-Acyl Derivative of Ecteinascidin 770 and Evaluation of Cytotoxicity2013

    • Author(s)
      Saito N., Tsujimoto M., Mori N., Pangkruang W., Puthongking P., Loutangkitcharoen W., Suwanborirux K.
    • Organizer
      The 9th AFMC International Medicinal Chemistry Symposium (ALMECS13)
    • Place of Presentation
      台湾(中華民国)
    • Related Report
      2013 Annual Research Report
  • [Presentation] エクチナサイジン770誘導体の合成と生物活性2013

    • Author(s)
      辻本光宏、森ななえ、齋藤直樹、L. Witaya, K. Suwanborirux
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 1,2,3,4-テトラヒドロイソキノリンのアセチル化に対する挙動2013

    • Author(s)
      中井啓陽、木村真也、横屋正志、齋藤直樹
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] サフラマイシンAの全合成アプローチ2013

    • Author(s)
      河合慎太郎、東雅之、木村真也、横屋正志、齋藤直樹
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 抗腫瘍活性海洋天然物レニエラマイシンMの全合成2013

    • Author(s)
      高田裕樹、三村政博、横屋正志、齋藤直樹
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 新規微量海洋天然物レニエラマイシンTの全合成研究:基本骨格の構築2013

    • Author(s)
      木村真也、齋藤直樹
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 海洋生物由来新規テトラハイドロイソキノリンアルカロイドによるヒトグリオーマ細胞に対するアポトーシス誘導機序の分子ネットワーク解析2013

    • Author(s)
      天竺桂弘子、島村悦光、野島陽水、川名夏生、K. Suwanborirux, K. Charupant, 齋藤直樹、佐藤準一
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 青色海綿由来イソキノリン海洋天然物の全合成研究2012

    • Author(s)
      横屋正志、伊藤裕史、齋藤直樹
    • Organizer
      第37回反応と合成の進歩シンポジウム
    • Place of Presentation
      徳島
    • Year and Date
      2012-11-07
    • Related Report
      2013 Final Research Report
  • [Presentation] レニエラマイシン海洋天然物の化学的研究:右半部モデルの二酸化セレン酸化による5位への酸素官能基の立体選択的導入2012

    • Author(s)
      森麻悠子、大工原直美、齋藤直樹
    • Organizer
      第38回反応と合成の進歩シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2012-11-05
    • Related Report
      2013 Final Research Report
  • [Presentation] Chemistry of Renieramycin Antitumor Marine Natural Products. An Improved Total Synthesis of (±)-Renieramycin G2012

    • Author(s)
      Naoki Saito, Kimiko Shinada-Fujuno, Masashi Yokoya
    • Organizer
      15^<th> tetrahedron Symposium
    • Place of Presentation
      Amsterdam (the Netherlands)
    • Year and Date
      2012-06-27
    • Related Report
      2013 Final Research Report
  • [Presentation] フィリピンに生息する青色海綿由来天然物の構造2012

    • Author(s)
      辰川真理、平出裕美、齋藤直樹、Hirbert D. S. Magpantay, Louvy L. C. Punzalan, Gisela P. Concepcion
    • Organizer
      日本薬学会第132 年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-31
    • Related Report
      2013 Final Research Report
  • [Presentation] Chemistry of renieramycin antitumor marine natural products. An improved total synthesis of (+/-)-renieramycin G2012

    • Author(s)
      Saito N., Shinada-Fujino K., Yokoya M.
    • Organizer
      13th Tetrahedron Symposium
    • Place of Presentation
      アムステルダム
    • Related Report
      2012 Research-status Report
  • [Presentation] 海洋天然物エクチナサイジンを新規制がん剤の創薬シードとする化学的研究2012

    • Author(s)
      鳥海悟、辻本光宏、Panithi Saktrakulkla, Chamnan Patarapanich, Khanit Suwanborirux, 齋藤直樹
    • Organizer
      第56回日本薬学会関東支部大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] フィルピンに生息する青色海綿が生産する新規レニエラマイシン海洋天然物の構造2012

    • Author(s)
      辰川真理、平出裕美、横屋正志、Louvy L. C. Punzalan, Hirbert D. S. Magpantay, Gisela P. Concepcion, 齋藤直樹
    • Organizer
      第56回日本薬学会関東支部大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] レニエラマイシンGの改良合成:工程数の短縮2012

    • Author(s)
      高田裕樹、横屋正志、三村正博、齋藤直樹
    • Organizer
      第56回日本薬学会関東支部大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] レニエラマイシン海洋天然物の化学的研究:右半部モデルの二酸化セレン酸化による5位への酸素官能基の立体選択的導入2012

    • Author(s)
      森麻悠子、大工原直美、齋藤直樹
    • Organizer
      第38回反応と合成の進歩シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 中井啓陽、横屋正志、齋藤直樹2012

    • Author(s)
      サフラマイシン・レニエラマイシンの部分合成と抗腫瘍活性
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Presentation] 横屋正志、品田貴美子、齋藤直樹2012

    • Author(s)
      レニエラマイシンGおよびその合成中間体の細胞毒性
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Presentation] 横屋正志、高田裕樹、三村政裕、齋藤直樹2012

    • Author(s)
      レニエラマイシンGの改良合成:工程数の短縮
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Presentation] 森 麻悠子、吉野美穂、齋藤直樹2012

    • Author(s)
      レニエラマイシンVの構造とモデル化合物の合成アプローチ
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Presentation] 辰川真理、平出裕美、齋藤直樹、他2012

    • Author(s)
      フィリピンに生息する青色海綿由来天然物の構造
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Presentation] Chemistry of Ecteinascidin Marine Natural Products: Synthesis of 6'-O- and 2'-N-Acyl Derivatives of Ecteinascidin 770 for Evaluation of Cytotoxicity2011

    • Author(s)
      Naoki Saito, Satoru Toriumu, Mitsuhiro Tsujimoto, Panithi Saktrakulkla, Khanit Suwanborirux
    • Organizer
      8^<th> FMC International Chemistry Symposium (AIMECS11)
    • Place of Presentation
      Tokyo (Japan)
    • Year and Date
      2011-12-02
    • Related Report
      2013 Final Research Report
  • [Presentation] Chemistry of Ecteinascidin Marine Natural2011

    • Author(s)
      Saito N.
    • Organizer
      8th AFMC Internat. Med. Chem. Sympo.
    • Place of Presentation
      Tokyo
    • Related Report
      2011 Research-status Report
  • [Presentation] 中井啓陽、横屋正志、齋藤直樹2011

    • Author(s)
      レニエラマイシン・サフラマイシン左半部モデル化合物の合成研究
    • Organizer
      第55回日本薬学会関東支部大会
    • Place of Presentation
      千葉
    • Related Report
      2011 Research-status Report
  • [Presentation] 横屋正志、伊東裕史、齋藤直樹2011

    • Author(s)
      青色海綿由来イソキノリン海洋天然物の全合成研究
    • Organizer
      第37回反応と合成の進歩シンポジウム
    • Place of Presentation
      徳島
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.my-pharm.ac.jp/pcns6mpu/wordpress/

    • Related Report
      2013 Final Research Report
  • [Remarks] 森ななえ、辻本光宏、ビタヤ・ロタンチャローン、カニ・スワンボリラック、齋藤直樹、タイ国に生息する群体ホヤ由来エクチナサイジン海洋天然物の抗腫瘍活性増強を目指した合成研究、第3 回CSJ 化学フェスタ、平成25 年10 月23 日、東京

    • Related Report
      2013 Final Research Report
  • [Remarks] 齋藤直樹、アジア圏に生息する海洋生物由来新規制癌剤の開発、イノベーシュン・ジャパン(大学見本市)、平成25 年8 月29-30日、東京ビックサイト

    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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