Organochemical Curving Using Catalytic Glycol-Cleavage
Project/Area Number |
23590024
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Chemical pharmacy
|
Research Institution | Shizuoka Institute of Science and Technology |
Principal Investigator |
|
Project Period (FY) |
2011-04-28 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | グリコール開裂 / 超原子価ヨウ素 / バナジウム / 酸素酸化 / 環境調和型合成 / 環拡大 / 有機彫刻 / 次亜塩素酸ナトリウム / 触媒的酸化反応 / 中大員環合成 / 分子内環化反応 / 環境調和型反応 / バナジウム触媒 / 開裂反応 / 中員環合成 / 大員環合成 / 環境調和型グリコール開裂 / 環化反応 |
Outline of Final Research Achievements |
Unfortunately, glycol-cleavage using vanadium-catalyzed aerobic oxidation was not effective for bicyclic glycols because of their steric hindrance. Therefore, we tried to find other environmentally benign glycol-cleavage, and found that hypervalent iodines can react with the bicyclic glycols to cause the glycol-cleavage. Furthermore, we developed glycol-cleavage using sodium hypochlorite catalyzed by iodobenzene. These reactions are effective for the glycol-cleavage of several bicyclic glycols which were synthesized using cyclization.
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Report
(5 results)
Research Products
(10 results)