| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
Neovibsanins were originally isolated from Viburnum awabuki by Fukuyama and co-workers in 1996. These natural products were found to display neurite outgrowth activity in PC12 cells, suggesting neovibsanin-type compounds could be promising candidates for the development of novel therapeutic agents to treat Alzheimer-type dementia. However, the detailed mechanism for the activity is still unknown. We carried out the syntheses of several kinds of neovibsanin derivatives on the basis of the tricyclic acetal which is a minimum essential structure expressing the activity, to clarify the detailed structure-activity relationship of neovibsanins. As the results, it was revealed that the C11 of neovibsanin skeleton is a suitable position for the substitution with photoaffinity-functional group. On the basis of these knowledge, the synthesis of the photoaffinity-labeled neovibsanin derivative, which is useful in order to find the target molecules having an affinity for neovibsanin, was achieved.
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