Development of direct catalytic asymmetric C-C bond-forming reactions based on thioamides and their applications to enantioselective synthesis of thtrapeutics
Project/Area Number |
23590038
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Chemical pharmacy
|
Research Institution | Microbial Chemistry Research Foundation |
Principal Investigator |
KUMAGAI Naoya 公益財団法人微生物化学研究会, 微生物化学研究所, 主任研究員 (40431887)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 不斉合成 / 不斉触媒 / チオアミド / 協奏機能触媒 / 医薬合成 / 原子効率 / 協奏機能型触媒 |
Research Abstract |
Several catalytic asymmetric reactions of synthetic value have been developed based on thioamide-based nucleophiles and electrophiles. These reactions were successfully utilized in short enantioselective synthesis of therapeutics.
|
Report
(3 results)
Research Products
(129 results)