Creation of Artificial Oxygen Carrier Using Supramolecular Complex
| Project/Area Number |
23590040
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
NEYA Saburo 千葉大学, 薬学研究科(研究院), 教授 (10156169)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 人工血液 / ミオグロビン / ポルフィリン / 非平面性ヘム / ピロール再配列 / 酸素親和性低下 / 超分子複合体 / 人工酸素運搬物質 / ポルフィリン異性体 / コルフィセン / 酸素結合能 / 有機ナノチューブ / 人工酸素運搬体 / 核磁気共鳴法 / タンパク質 / 分子分光法 |
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| Research Abstract |
The development of artificial oxygen carrier is essential to support the stable blood transfusion. Artificial oxygen carrier is free from problem of blood type or blood infection, and it is preserved for longer period than blood itself. The blood substitutes so far developed are mainly from hemoglobin and related materials. Myoglobin has an advantage over hemoglobin because it is free from the influence of allosteric effector of solution pH. However, myoglobin has not been used as the blood substitute because of the extremely high oxygen affinity. We have developed a research to donate appropriate oxygen-transporting ability to myoglobin, and to utilize it as an efficient oxygen carrier. The rearrangement of the tetrapyrrole array in the porphyrin ring was quite effective to control the oxygen delivery. We found that the myoglobin reconstituted iron corrphycene, a trapezoidal heme, exhibits sufficient ability for oxygen delivery.
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Report
(4 results)
Research Products
(74 results)
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[Journal Article] (12,17-Diethoxycarbonyl-11,18-dimethyl-2,3,6,7-dibutanocorrphycenato)copper(II)2012
Author(s)
Yoshiki, Ohgo, Yuki Yokoyama, Daisuke Hashizuma, Saburo Neya, and Mikio Nakamura
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Journal Title
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Peer Reviewed
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[Presentation] Regulation of functional properties of myoglobin through tuning heme electronic structure.2012
Author(s)
Y. Yamamoto, R. Nishimura, T. Shibata, H. Tai, K. Nishiyama, D. Matsumoto, M. Fukaya, S. Nagao, S. Neya, A. Suzuki.
Organizer
7th Internstional Conference on Porphyrins and Phthalocyanines.
Place of Presentation
Jeju, Korea
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[Book] 元素検定2011
Author(s)
桜井 弘、 根矢 三郎、寺嶋 孝仁
Total Pages
265
Publisher
化学同人
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