| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
An LC-MS/MS method wad developed for determination of 4 folate derivatives such as folic acid, tetrahydrofolate, 5-methyltetrahydrofolate and 5-folmyltetrahydrofolate in human whole blood. The method was enough sensitive to determine the folates in blood. The limit of detection were in the range of 0.13 nM-1.10 nM at signal-to-noise ratio of 3. Furthermore, the method could be successfully applied to determine the folate in healthy human blood.
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