Design and evaluation of cancer cell-specific and systemic siRNA delivery system that clinical application is available for
| Project/Area Number |
23590045
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
ARIMA HIDETOSHI 熊本大学, 大学院生命科学研究部, 教授 (50260964)
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| Co-Investigator(Renkei-kenkyūsha) |
MOTOYAMA Keiichi 熊本大学, 大学院生命科学研究部, 准教授 (50515608)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | シクロデキストリン / デンドリマー / siRNA / 腫瘍特異的 / 葉酸受容体 / RNAi効果 / 安全性 / 抗腫瘍効果 / 葉酸 / がん / 標的指向化 / ＤＤＳ / ジェネレーション / PEG化葉酸 / 腫瘍特異的デリバリー / 抗がん剤 / 全身デリバリー |
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| Research Abstract |
Fol-PEG-alpa-CDE (G4) which newly adorned pegylated folate as a cancer cell-selective moiety in alpa-cyclodextrin/dendrimer conjugate (alpa-CDE (G4)) which was the new siRNA carrier developed by us is likely to be useful for as the novel cancer specific and systemic siRNA carrier which has potent stability and blood retention, compared to alpa-CDE (G4) and Fol-PEG-alpa-CDE (G3). We are going to build the novel cancer treatment system which has more potent efficacy and safety in clinical use by constructing the cancer environment-responsible siRNA releasing system appended various functional groups and a co-delivery system of the nucleic acid drug with an anticancer drug, based on Fol-PEG-alpa-CDE (G4).
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Folate-PEG-appended dendrimer conjugate with α-cyclodextrin as a novel cancer cell-selective siRNA delivery carrier2012
Author(s)
H. Arima, A. Yoshimatsu, H. Ikeda, A. Ohyama, K. Motoyama, T. Higashi, A. Tsuchiya, T. Niidome, Y. Katayama, K. Hattori, T. Takeuchi
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Journal Title
Mol. Pharmaceutics
Volume: 9
Issue: 9
Pages: 2591-2604
DOI
Related Report
Peer Reviewed
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