Development of targeting liposomal drugs using functional coating a folate-polymer conjugate
| Project/Area Number |
23590054
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Keio University (2013)
Hoshi University (2011-2012) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ターゲティング / ナノ製剤 / リポソーム / リガンド / がん治療 / 葉酸 / 葉酸高分子 |
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| Research Abstract |
The tumor targeting of anticancer drugs is important in chemotherapy to reduce serious side-effect for patients. Folate-polymer-coated liposomes were developed for targeted chemotherapy using doxorubicin (DXR) as a model drug. Folate-poly(L-lysine) (F-PLL) conjugates were synthesized. DXR-loaded anionic liposomes were coated with F-PLL, using Layer-by layer method. In KB cells overexpressing folate receptors, F-PLL-coated liposomal DXR increased the cellular association and cytotoxicity compared with that of PLL-coated liposomes. Differently in folate-PEG modified liposome, higher folate conjugated PLL-coated liposome showed higher KB cellular uptake, suggesting different distribution of folate at the surface of liposomes.
Folate-targeted liposomes were prepared successfully by coating the folate-polymer-conjugate F-PLL.
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Report
(4 results)
Research Products
(13 results)
