Development of non-invasive delivery of biopharmaceuticals equipped with novel membrane permeation technology and their translational research
| Project/Area Number |
23590056
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Kobe Gakuin University (2012-2013)
Hoshi University (2011) |
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Principal Investigator |
TAKEDA Mariko 神戸学院大学, 薬学部, 教授 (70257096)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAYAMA Kozo 星薬科大学, 薬学部, 教授 (00130758)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ドラッグデリバリー / バイオ医薬 / 非侵襲的投与経路 / 吸収促進 / バイオアベイラビリティ / インスリン / 細胞膜透過ペプチド / ペネトラチン / バイオ薬物 / 経口吸収 / 薬物送達システム / 経鼻吸収 / バイオアベリラビリティ / 経口投与 |
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| Research Abstract |
The purpose of this study was to establish non-invasive delivery systems for biodrugs based on new delivery tool: cell-penetrating peptides (CPPs) and to perform translational research, and the following results were obtained: 1) Elucidation of main mechanism of membrane permeation enhancing effects by CPPs, 2) Novel peptide sequence (PenetraMax) that is superior to natural CPPs was obtained by in silico exploratory research using an artificial neural network, 3) Clarification of CPPs' high safety systemically and locally by in vivo toxicity tests. Furthermore, useful knowledge for development of the clinical formulations of CPPs, and based on the above results, an experimental conditions to perform oral PET imaging studies were established.
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Report
(4 results)
Research Products
(67 results)
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[Presentation] Long-term effectiveness and systemic/local safety of novel penetratin analogue for nasal insulin delivery2013
Author(s)
Kamei N, Khafagy El-S, Hamamoto Y, Shiba H, Iwamae R, Kaiguchi M, Tanaka F, Matsumoto Y, Nielsen EJB, Nishio R, Takeda-Morishita M.
Organizer
The 5th Asian Arden Conference
Place of Presentation
Nagoya, Japan
Related Report
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[Presentation] One-month subchronic toxicity study of cell-penetrating peptides on insulin nasal delivery in rats2013
Author(s)
Khafagy El-S, Kamei N, Hamamoto Y, Shiba H, Iwamae R, Kaiguchi M, Tanaka F, Matsumoto Y, Nielsen EJB, Nishio R, Takeda-Morishita M.
Organizer
日本薬剤学会第28年会
Place of Presentation
名古屋
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