Efficient Skin Delivery of Polyphenols by Microemulsions and Its Mechanisms
| Project/Area Number |
23590060
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | マイクロエマルション / ポリフェノール / レスベラトロール / クロロゲン酸 / 皮膚デリバリー / 皮膚中分布 / ポリグリセリン脂肪酸エステル / ポリグリセリンラウリン酸エステル / ショ糖ラウリン酸エステル / エピカテキン / テトラグリセリンラウリン酸エステル / 真皮移行性 / エアロゾルOT / 1,3-ブタンジオール / 界面活性剤 |
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| Research Abstract |
To deliver polyphenols such as resveratrol to skin, we prepared microemulsions using polyglycerin fatty acid esters and other surfactants, , which are known to be mild to skin. We examined the efficiency of intradermal delivery of polyphenols by in vitro study. The efficiencies of skin accumulation of polyphenols by the microemulsions using tetraglycerin mono-laurate or pentaglycerin mono-laurate as surfactant components were twice or three times more than those by microemulsions using Tween 80 as a surfactant component, which we had used. We also found different skin distribution of the polyphenols. Hydrophobic resveratrol with small molecular weight distributed to the dermis more than to the epidermis. On the other hand, hydrophilic chlorogenic acid with larger molecular weight distributed mostly to the epidermis. Therefore, polyphenols should be selected for purpose of skin application to skin.
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Report
(4 results)
Research Products
(37 results)
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[Presentation]2012
Author(s)
長谷川巧,湯谷玲子,森田真也,寺岡麗子,北河修治
Organizer
日本薬学会第132年会
Place of Presentation
札幌
Year and Date
2012-03-30
Related Report
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