| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
Matrix metalloproteinase 13(MMP13) is key enzyme to cleave collagen, that is the substrate for bone and cartilage. Recently we generated gene deficient mice of MMP13 (MMP13KO). In this investigation, we examined the role of the host produced MMP13 in tumor metastasis and formation in various species of cancer, that was using newly establishing methods of evaluation model of cancer metastasis. These findings indicted that the potential for drug development of MMP13 inhibitors in clinical use.
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