The physiological roles of the phosphorylation of heterotrimeric G protein signal-dependent RhoGEFs
| Project/Area Number |
23590073
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Gifu University |
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Principal Investigator |
UEDA Hiroshi 岐阜大学, 工学部, 准教授 (50253779)
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| Co-Investigator(Kenkyū-buntansha) |
AKAO Yukihiro 岐阜大学, 連合創薬医療情報研究科, 教授 (00222505)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | シグナル伝達 / RhoGEF / Rho / チロシンリン酸化 / キナーゼ / リン酸化 / 三量体G蛋白質 / アクチン |
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| Outline of Final Research Achievements |
Rho family GTPase-specific guanine nucleotide exchange factors of Dbl family regulate a variety of cellular events including cytoskeletal arrangement, signal transduction, and gene expression through activation of Rho family GTPases. FLJ00018/CLG/PLEKHG2 is a guanine nucleotide exchange factor (GEF) for Rho family of small GTPases. In this research project, we have examined the regulation mechanisms of PLEKHG2 by phosphorylation and protein-protein interactions. We showed here that PLEKHG2 interacted with cytosolic actin or phosphoinositide containing PtdIns(4,5)P2, PtdIns(3,4,5)P3 and phosphatidic acid. We showed that PLEKHG2 was phosphorylated by tyrosine kinase Src or EGF receptor signals.
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Report
(5 results)
Research Products
(17 results)
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[Journal Article] Identification of a Rho family specificguanine nucleotide exchange factorFLJ00018, as a novel actin-bindingprotein2013
Author(s)
Sato, K., Handa, H., Kimura, M., Okano,Y., Nagaoka, H., Nagase, T., Sugiyama,T., Kitade, Y., and Ueda, H.
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Journal Title
Cell. Signal.
Volume: 25
Issue: 1
Pages: 41-49
DOI
Related Report
Peer Reviewed
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[Journal Article] Mechanism of inhibition of lipopolysaccharide-induced interferon-β production by 2-aminopurine.2012
Author(s)
Sugiyama T., Gotou T., Moriyama K., Nodoka Kajiura K., Hasegawa T., Tomida J., Takahashi K., Komatsu T., Ueda H., Sato K., Tokoro S., Neri P. and Mori H.
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Journal Title
Mol. Immun.
Volume: 52
Issue: 3-4
Pages: 299-304
DOI
Related Report
Peer Reviewed
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