| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
In the microRNAs whose expressions are changed in human esophageal squamous cell carcinoma as compared with neighboring normal tissues, I found that three microRNAs are involved in cancer cell survival and proliferation and other two microRNAs are involved in cancer cell migration. Furthermore, I comprehensively identified target candidate genes degraded by these microRNA in esophageal squamous cell carcinoma cells. Migration of esophageal squamous cell carcinoma cells was inhibited by each knockdown of two target genes among six target genes of the microRNA, which was most potently inhibited cancer cell migration. As these target genes play important roles on exosytic release, my findings show for the first time the possibility that esophageal squamous cell carcinoma cells accelerate cancer cell migration through exosytic release system.
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