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Lysophosphatidic acid production by novel membrane-bound lysophospholipase D and protection of oral mucosa

Research Project

Project/Area Number 23590079
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biological pharmacy
Research InstitutionThe University of Tokushima

Principal Investigator

TOKUMURA Akira  徳島大学, ヘルスバイオサイエンス研究部, 教授 (00035560)

Co-Investigator(Kenkyū-buntansha) TANAKA Tamotsu  徳島大学, 大学院ヘルスバイオサイエンス 研究部, 准教授 (90258301)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywordsリゾホスファチジン酸 / リゾホスホリパーゼD / リゾホスファチジルコリン / 歯肉溝浸出液 / 歯肉上皮細胞 / 口腔粘膜 / 歯周病 / 骨芽細胞 / リゾリン脂質メディエーター / リゾホスホリパーゼC / 歯肉上皮 / ドライマウス / リゾリン脂質 / ホスホリパーゼ / 歯肉
Research Abstract

Lysophosphatidic acid (LPA) is a member of lysophopsholipid mediator family that has recently attracted much attention, and exert diverse physiological effects through the activation of six its specific receptors.
In the present study, the concentration of LPA in human gingival crevicular fluid (GCF) from healthy volunteers was found to be more than ten times higher human than thatin human mixed saliva, but the LPA levelin GCF from patients with periodontitis was found to be very low by liquid chromatography-tandem mass spectrometry. The latter was found to be due to much high er activity of LPA-degrading in GCF from the periodontitis patients. These results strongly indicate that local depletion of LPA around the alveolar bones results in the altered bone absorption leading to the aggravation of periodontits, because LPA is known to be involved in the bone remodeling.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (5 results)

All 2013 2012 Other

All Presentation (5 results) (of which Invited: 3 results)

  • [Presentation] リン脂質メディエーター代謝異常と生活習慣病2013

    • Author(s)
      徳村彰
    • Organizer
      日本脂質栄養学会第22回大会特別講演
    • Place of Presentation
      高知会館(高知県)
    • Year and Date
      2013-09-12
    • Related Report
      2013 Final Research Report
  • [Presentation] Generation of lysolipid mediators by membrane-bound lysophospholipase C and D in the surface of mammalian cells2013

    • Author(s)
      Akira Tokumura
    • Organizer
      FASEB Summer Research Conference on Lysophospholipid Mediators
    • Place of Presentation
      Niseko (Hokkaido)
    • Year and Date
      2013-08-12
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] ヒト口腔粘膜上皮細胞で産生されるリゾホスファチジン酸によるオートクリン的細胞機能調節2012

    • Author(s)
      横田美帆他
    • Organizer
      第51回日本薬学会中国四国支部大会
    • Place of Presentation
      サンラポーむらくも(島根)
    • Related Report
      2012 Research-status Report
  • [Presentation] Generation of lysolipid mediators by membrane-bound lysophospholipase C and D in the surface of mammalian cells

    • Author(s)
      徳村 彰
    • Organizer
      FASEB Summer Research Conference on Lysophospholipid Mediators
    • Place of Presentation
      ヒルトンニセコビレッジ(北海道)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] リン脂質メディエーター代謝異常と生活習慣病

    • Author(s)
      徳村 彰
    • Organizer
      日本脂質栄養学会第22回大会
    • Place of Presentation
      高知会館(高知県)
    • Related Report
      2013 Annual Research Report
    • Invited

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Published: 2011-08-05   Modified: 2019-07-29  

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