Study of the molecular mechanism underlying interaction between immune system and nervous system
Project/Area Number |
23590086
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Biological pharmacy
|
Research Institution | Health Sciences University of Hokkaido |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Machiko 北海道医療大学, 薬学部, 准教授 (70229574)
TOGASHI Hiroko 北海道医療大学, 薬学部, 教授 (20113590)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | アドレナリン受容体 / IL-33 / REDD1 / トランスグルタミナーゼ2 / ストレス / マクロファージ / 樹状細胞 / 免疫制御 / インターロイキン-33 / 免疫系と神経系 / TLR7 / ストレスと免疫 / アドレナリン |
Research Abstract |
In the present study, we examined the effects of the stress-related catecholamines adrenaline and noradrenaline on the functions of dendritic cells and macrophages. We found adrenoceptor-mediated increase in IL-33, REDD1, and transglutaminase 2 expressions by these cells. Because stress events activate the sympathetic nervous system and result in secretion of the catecholamines, adrenoceptor-mediated increase in these molecules might be associated with stress-related inflammatory disorders.
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Report
(4 results)
Research Products
(34 results)