Molecular mechanism for malignant cell transformationinduced by a peptide derived from tenascin C through integrin activation
| Project/Area Number |
23590090
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
FUKAI Fumio 東京理科大学, 薬学部・生命創薬科学科, 教授 (90124487)
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| Co-Investigator(Kenkyū-buntansha) |
IYODA Takuya 東京理科大学, 薬学部・生命創薬科学科, 助教 (80465715)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 細胞生物学 / 細胞接着 / インテグリン / テネイシンC / 神経膠芽腫 / PDGF / 悪性腫瘍 / 細胞増殖 / 悪性転換 / テネイシン / がん |
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| Research Abstract |
Following results were obtained by the present study: 1) Peptide TNIIIA2 derived from tenascin-C (TNC) has the ability to induce potentiated and sustained activation in beta1-integrins, 2) TNIIIA2 is capable of inducing hyperstimulation of cell survival and proliferation though activation of integrins, 3) TNIIIA2 may serve as a tumor promotor. These results provide important basis for understanding of the role of TNC in tumor initiation and promotion
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Report
(3 results)
Research Products
(18 results)
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[Journal Article]2012
Author(s)
Matsunaga T, Fukai F, Kameda T, Shide K, Shimoda H, Torii E, Kamiunten A, Sekine M, Yamamoto S, Hidaka T, Kubuki Y, Yokokura S, Uemura M, Matsuoka A, Waki F, Matsumoto K, Kanaji N, Ishii T, Imataki O, Dobashi H, Bandoh S, Shimoda K.
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Journal Title
Ann Hamatol
Volume: 91(10)
Pages: 1633-1643
Related Report
Peer Reviewed
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[Journal Article] Eukaryotic translation elongation factor 1A induces anoikis by triggering cell detachment2012
Author(s)
Itagaki, K., Naito, T., Iwakiri, R., Haga, M., Miura S., Saito Y., Owaki, T., Kamiya, S., Iyoda, T., Yajima, H., Iwashita, S., Ejiri, S., and Fukai, F.
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Journal Title
J Biol Chem
Volume: 287
Pages: 16037-16046
Related Report
Peer Reviewed
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[Journal Article] Elevated HIF-1αexpression of acute myelogenous leukemia stem cells in the endosteal hypoxic zone may be a cause of minimal residual disease in bone marrow after chemotherapy2012
Author(s)
Matsunaga T, Imataki O, Torii E, Kameda T, Shide K, Shimoda H, Kamiunten A, Sekine M, Taniguchi Y, Yamamoto S, Hidaka T, Katayose K, Kubuki Y, Dobashi H, Bandoh S, Ohnishi H, Fukai F, Shimoda K.
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Journal Title
Leukemia Res
Volume: 36
Pages: 122-124
Related Report
Peer Reviewed
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