• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular mechanism for malignant cell transformationinduced by a peptide derived from tenascin C through integrin activation

Research Project

Project/Area Number 23590090
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biological pharmacy
Research InstitutionTokyo University of Science

Principal Investigator

FUKAI Fumio  東京理科大学, 薬学部・生命創薬科学科, 教授 (90124487)

Co-Investigator(Kenkyū-buntansha) IYODA Takuya  東京理科大学, 薬学部・生命創薬科学科, 助教 (80465715)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords細胞生物学 / 細胞接着 / インテグリン / テネイシンC / 神経膠芽腫 / PDGF / 悪性腫瘍 / 細胞増殖 / 悪性転換 / テネイシン / がん
Research Abstract

Following results were obtained by the present study: 1) Peptide TNIIIA2 derived from tenascin-C (TNC) has the ability to induce potentiated and sustained activation in beta1-integrins, 2) TNIIIA2 is capable of inducing hyperstimulation of cell survival and proliferation though activation of integrins, 3) TNIIIA2 may serve as a tumor promotor. These results provide important basis for understanding of the role of TNC in tumor initiation and promotion

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (18 results)

All 2012 2011

All Journal Article (11 results) (of which Peer Reviewed: 10 results) Presentation (6 results) Book (1 results)

  • [Journal Article] The cell adhesion and proliferation activities of a peptide derived from human tenascin-C are dependent on two Ile residues2012

    • Author(s)
      Hayashi R., Miura, S., Saito Y., Osada S., Iyoda, T., Fukai, F., and Kodama H
    • Journal Title

      Bioorg. Med Chem

      Volume: 20 Pages: 4608-4613

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article]2012

    • Author(s)
      Matsunaga T, Fukai F, Kameda T, Shide K, Shimoda H, Torii E, Kamiunten A, Sekine M, Yamamoto S, Hidaka T, Kubuki Y, Yokokura S, Uemura M, Matsuoka A, Waki F, Matsumoto K, Kanaji N, Ishii T, Imataki O, Dobashi H, Bandoh S, Shimoda K.
    • Journal Title

      Ann Hamatol

      Volume: 91(10) Pages: 1633-1643

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Eukaryotic translation elongation factor 1A induces anoikis by triggering cell detachment2012

    • Author(s)
      Itagaki, K., Naito, T., Iwakiri, R., Haga, M., Miura S., Saito Y., Owaki, T., Kamiya, S., Iyoda, T., Yajima, H., Iwashita, S., Ejiri, S., and Fukai, F.
    • Journal Title

      J Biol Chem

      Volume: 287 Pages: 16037-16046

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Elevated HIF-1αexpression of acute myelogenous leukemia stem cells in the endosteal hypoxic zone may be a cause of minimal residual disease in bone marrow after chemotherapy2012

    • Author(s)
      Matsunaga T, Imataki O, Torii E, Kameda T, Shide K, Shimoda H, Kamiunten A, Sekine M, Taniguchi Y, Yamamoto S, Hidaka T, Katayose K, Kubuki Y, Dobashi H, Bandoh S, Ohnishi H, Fukai F, Shimoda K.
    • Journal Title

      Leukemia Res

      Volume: 36 Pages: 122-124

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of tumor cell survival, proliferation, and differentiation by the peptide derived from tenascin-C2012

    • Author(s)
      Iyoda, T., and Fukai, F
    • Journal Title

      Int. J Cell Biol. 2012

      Volume: Article ID 647594 Pages: 10-10

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potentiated activation of VLA-4 and VLA-5 accelerates proplatelet-like formation2012

    • Author(s)
      Takuya Matsunaga
    • Journal Title

      Ann Hematol

      Volume: 91 Pages: 1633-1643

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevated HIF-1α expression of acute myelogenous leukemia stem cells in the endosteal hypoxic zone may be a cause of minimal residual disease in bone marrow after chemotherapy2012

    • Author(s)
      Takuya Matunaga
    • Journal Title

      Leukemia Res

      Volume: 36 Pages: 122-124

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Eukaryotic translation elongation factor 1A induces anoikis by triggering cell detachment.2012

    • Author(s)
      Keisuke Itagaki
    • Journal Title

      J Biol Chem

      Volume: 287 Pages: 16037-16048

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of tumor cell survival, proliferation, and differentiation by the peptide derived from tenascin-C2012

    • Author(s)
      Takuya Iyoda
    • Journal Title

      Int J Cell Biol

      Volume: 2012 Pages: 647594-647604

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Eukaryotic translation elongation factor 1A induces anoikis by triggering cell detachment.2012

    • Author(s)
      Itagaki, K.,
    • Journal Title

      J. Biol. Chem.

      Volume: 287 Pages: 16037-16046

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Modulation of tumor cell survival, proliferation, and differentiation by the peptide derived from tenascin-C.2012

    • Author(s)
      Iyoda, T., and Fukai, F.
    • Journal Title

      Int. J. Cell Biol.

      Volume: 2012

    • Related Report
      2011 Research-status Report
  • [Presentation] テネイシンC分子由来のインテグリン活性化ペプチドによる神経膠芽腫細胞のPDGF依存性増殖、移動能の過剰増強2012

    • Author(s)
      藤田元道、藤澤達也、伊豫田拓也、深井文雄
    • Organizer
      第2回テネイシンフォーラム
    • Place of Presentation
      東京理科大学・森戸記念館
    • Year and Date
      2012-11-10
    • Related Report
      2012 Final Research Report
  • [Presentation] 細胞接着分子を標的とした新しい治療薬の開発2012

    • Author(s)
      深井文雄
    • Organizer
      第23回新薬創製談話会
    • Place of Presentation
      熱海
    • Year and Date
      2012-09-11
    • Related Report
      2012 Final Research Report
  • [Presentation] テネイシンC分子由来のインテグリン活性化ペプチドによる神経膠芽腫細胞のPDGF依存性増殖、移動能の過剰増強2012

    • Author(s)
      藤田元道、藤澤達也、伊豫田拓也、深井文雄
    • Organizer
      日本薬学会第132年会(北海道大学
    • Place of Presentation
      札幌(横浜)
    • Year and Date
      2012-03-29
    • Related Report
      2012 Final Research Report
  • [Presentation] テネイシン C 由来のペプチドTNIIIA2 は PDGF 依存性の細胞増殖を過度に促進する2011

    • Author(s)
      大塚一樹、藤澤達也、伊豫田拓也、深井文雄
    • Organizer
      第1回テネイシンフォーラム
    • Place of Presentation
      三重大学医学部
    • Year and Date
      2011-11-05
    • Related Report
      2012 Final Research Report
  • [Presentation] Cell regulation by cryptic functional sites in fibronectin and tenascin-C molecules2011

    • Author(s)
      Fumio Fukai
    • Organizer
      10th Osteoponchin meeting
    • Place of Presentation
      北海道大学医学部、札幌
    • Year and Date
      2011-06-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Cell Regulation by Cryptic Functional Sites in Fibronectin and Tenascin-C Molecules2011

    • Author(s)
      Fumio Fukai
    • Organizer
      10th Osteopontin Meeting(招待講演)
    • Place of Presentation
      Hokkaido University
    • Related Report
      2011 Research-status Report
  • [Book] Cell regulation through membrane raft/caveolae in Electrical Phenomena at Interfaces and Biointerfaces: Fundamentals and Applications in Nano-, Bio-, and Environmental Sciences2012

    • Author(s)
      Yohei Saito, Toshiyuki Owaki, and Fumio Fukai
    • Publisher
      John Wiley & Son
    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi