| Project/Area Number |
23590093
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
NABE Takeshi 京都薬科大学, 薬学部, 准教授 (40228078)
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| Co-Investigator(Kenkyū-buntansha) |
MIZUTANI Nobuaki 神戸薬科大学, 薬理学研究室, 講師 (90340447)
FUJII Masanori 京都薬科大学, 薬理学分野, 助教 (40434667)
YASUI Hiroyuki 京都薬科大学, 代謝分析学分野, 教授 (20278443)
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| Research Collaborator |
CHAPLIN David D 米国アラバマ大学バーミングハム校, 微生物学, 教授
WEAVER Casey T 米国アラバマ大学バーミングハム校, 病理学, 教授
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 好中球 / 気道炎症 / 喘息 / COPD / 動物モデル / インターロイキン-10 / 制御性T細胞 / 免疫療法 / 気管支喘息 / 慢性閉塞性肺疾患 / マクロファージ / 気道リモデリング / 遅発性喘息反応 / アレルギー / IL-33 / 肥満細胞 / 好塩基球 |
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| Research Abstract |
Neutrophilic airway inflammation, a characteristic feature of severe asthma and chronic obstructive pulmonary disease (COPD), was analyzed using murine models, and regulation of the neutrophilic inflammation was evaluated. Unexpectedly, a good COPD model could not be developed even when cigarette smoke was co-administered with an infection factor to mice for a long term. On the other hand, in a murine model of severe asthma, neutrophils were involved in airway obstruction induced several hours after exposure to allergen. It was also found that macrophage-derived chemokines were involved in the neutrophilic airway inflammation. In addition, the neutrophilic inflammation was suppressed by an anti-inflammatory molecule, interleukin (IL)-10, which was endogenously produced. Next, development of a new cellular immunotherapy for asthma was started: Method for induction of IL-10-producing T lymphocytes from spleen cells was developed in vitro.
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