• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Role of cytochrome c as a novel signaling molecule by the investigation of LRG knock-out mouse

Research Project

Project/Area Number 23590096
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biological pharmacy
Research InstitutionOsaka University of Pharmaceutical Sciences

Principal Investigator

INOUE Seiji  大阪薬科大学, 薬学部, 准教授 (70183184)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords生体分子 / 蛋白質 / 生理活性
Research Abstract

Leucine-rich alpha2-glycoprotein (LRG), one of the serum proteins with unknown function, was found to bind tightly and form complex with the extracellular cytochrome c (Cytc). The positive charges of the residues 8, 13, 72, 73, and 79 of Cytc molecule were important to this binding. A Cytc-LRG complex would function as a danger signal that modulates the immune cells such as bone marrow-derived macrophages to induce G-CSF expression, leading to the neutrophil proliferation in bone marrow.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (7 results)

All 2014 2013 Other

All Presentation (5 results) Remarks (2 results)

  • [Presentation] ロイシンリッチα2-グリコプロテインとシトクロムcの相互作用2014

    • Author(s)
      井上晴嗣、松村有紗、矢野可央里、藤井忍、福永理己郎、池田潔
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Year and Date
      2014-03-28
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 新規シグナル分子としての細胞外シトクロムcの機能2013

    • Author(s)
      西村恵子、宮地由香里、村上弦大、伊狩光、土屋孝弘、藤井忍、福永理己郎、池田潔、井上晴嗣
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2013-09-12
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] ロイシンリッチα2-グリコプロテインとシトクロムcの相互作用2013

    • Author(s)
      矢野可央里、松村有紗、藤井忍、福永理己郎、池田潔、井上晴嗣
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2013-09-12
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 新規シグナル分子としての細胞外シトクロムcの役割2013

    • Author(s)
      井上晴嗣、村上弦大、伊狩光、土屋孝弘、藤井忍、福永理己郎、池田潔
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 新規シグナル分子としての細胞外シトクロムcの役割2013

    • Author(s)
      井上晴嗣、村上弦大、伊狩光、土屋孝弘、藤井忍、福永理己郎、池田潔
    • Organizer
      日本薬学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.oups.ac.jp/kenkyu/kenkyuushitu/seika.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 研究室紹介 生化学研究室

    • URL

      http://www.oups.ac.jp/kenkyu/kenkyuushitu/seika.html

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi