| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Research Abstract |
Leucine-rich alpha2-glycoprotein (LRG), one of the serum proteins with unknown function, was found to bind tightly and form complex with the extracellular cytochrome c (Cytc). The positive charges of the residues 8, 13, 72, 73, and 79 of Cytc molecule were important to this binding. A Cytc-LRG complex would function as a danger signal that modulates the immune cells such as bone marrow-derived macrophages to induce G-CSF expression, leading to the neutrophil proliferation in bone marrow.
|
