| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Life cycle of hepatitis C virus (HCV) is still poorly understood. In this project, I was trying to isolate host cell mutants resistant to HCV infection and to identify the defective genes in the mutants. A lot of hepatic cell mutants defective in HCV infection were established, and I found several novel host factors substantially involved in HCV infection. From the results of various analyses using established cell mutants defective in HCV infection, I also confirmed that a tight junction protein occludin is essential for both cell-free HCV entry and cell-to-cell HCV transmission in hepatic cells, and would be therefore a promising anti-HCV drug target.
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