| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
In this study, the following data were obtained: 1) activation of cPLA2alpha mediated by lactosylceramide in TNFalpha-stimulated cells, 2) development of new ceramide analogs inhibiting cPLA2alpha activity, 3) activation of alkaline caramidase by c-Src, 4) an interaction between cellular cholesterol and ceramide metabolites.
In addition, we showed 5) dual regulation of TGFbeta-induced fibrosis by S1P: stimulation by S1P3 receptor activation and inhibition by S1P1 receptor activation, and 6) an inhibitory effect of cyclosporin on TGFbeta-induced fibrosis in human lung fibroblasts.
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