Development of reagents regulating metabolism of ceramide and aranidonic acid and its application to lung disorder
Project/Area Number |
23590106
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Biological pharmacy
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Research Institution | Chiba University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
NISHIDA Atsushi 千葉大学, 大学院薬学研究院, 教授 (80130029)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | セラミド / アラキドン酸 / 肺線維症 / セラミド代謝酵素 / セラミダーゼ / 肺がん細胞 / セラミド代謝 / セラミド誘導体 / ホスホリパーゼA2 / 肺繊維症 / セラミド-1-リン酸誘導体 / ホスホリパーゼA2 |
Research Abstract |
In this study, the following data were obtained: 1) activation of cPLA2alpha mediated by lactosylceramide in TNFalpha-stimulated cells, 2) development of new ceramide analogs inhibiting cPLA2alpha activity, 3) activation of alkaline caramidase by c-Src, 4) an interaction between cellular cholesterol and ceramide metabolites. In addition, we showed 5) dual regulation of TGFbeta-induced fibrosis by S1P: stimulation by S1P3 receptor activation and inhibition by S1P1 receptor activation, and 6) an inhibitory effect of cyclosporin on TGFbeta-induced fibrosis in human lung fibroblasts.
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Report
(4 results)
Research Products
(54 results)
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[Journal Article] Effects of Hsp90 inhibitors, geldanamycin and its analog, on ceramide metabolism and cytotoxicity in PC12 cells.2012
Author(s)
Toyomura K, Saito T, Emori S, Matsumoto I, Kato E, Kaneko S, Okuma Y, Nakamura H, Murayama T.
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Journal Title
J Toxicol Sci
Volume: 37
Pages: 1049-1057
NAID
Related Report
Peer Reviewed
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