Pathophysiological significance of sialic acid in CNS
| Project/Area Number |
23590108
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | シアル酸 / 神経細胞 / ミクログリア / 中枢神経系 / シアリダーゼ / 炎症 |
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| Research Abstract |
Sialic acid is increased in serum and spinal fluid of CNS disease patients. Therefore to examine effects of sialic acid in pathophysiological situation, following are examined: 1) An effect of sialic acid on a function of microglia was performed. Desialylation on microglia induced significant expressions of inflammatory cytokines. 2) An effect of sialic acid on function of neuron was performed. Desialylation on neuron required for significant neurite outgrowth by neurite inducers. 3) An effect of desialylation in the brain was performed. Desialylation induced significant microglial activation and neuronal loss, indicating that desialylation induced neuronal damage which might be correlated with CNS disease.
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Report
(4 results)
Research Products
(37 results)
