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Pathophysiological significance of sialic acid in CNS

Research Project

Project/Area Number 23590108
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biological pharmacy
Research InstitutionKumamoto University

Principal Investigator

HISATSUNE Akinori  熊本大学, 大学院先導機構, 特任准教授 (50347001)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsシアル酸 / 神経細胞 / ミクログリア / 中枢神経系 / シアリダーゼ / 炎症
Research Abstract

Sialic acid is increased in serum and spinal fluid of CNS disease patients. Therefore to examine effects of sialic acid in pathophysiological situation, following are examined: 1) An effect of sialic acid on a function of microglia was performed. Desialylation on microglia induced significant expressions of inflammatory cytokines. 2) An effect of sialic acid on function of neuron was performed. Desialylation on neuron required for significant neurite outgrowth by neurite inducers. 3) An effect of desialylation in the brain was performed. Desialylation induced significant microglial activation and neuronal loss, indicating that desialylation induced neuronal damage which might be correlated with CNS disease.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (37 results)

All 2014 2013 2012 2011 Other

All Journal Article (19 results) (of which Peer Reviewed: 19 results) Presentation (18 results)

  • [Journal Article] Suppression of CXCL2 upregulation underlies the therapeutic effect of the retinoid Am80 on intracerebral hemorrhage in mice2014

    • Author(s)
      Matsushita H, Hijioka M, Ishibashi H, Anan J, Kurauchi Y, Hisatsune A, Seki T, Shudo K, Katsuki H
    • Journal Title

      J Neurosci Res

      Volume: (Epub ahead of print)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of CXCL2 upregulation underlies the therapeutic effect of the retinoid Am80 on intracerebral hemorrhage in mice.2014

    • Author(s)
      Matsushita H, Hijioka M, Ishibashi H, Anan J, Kurauchi Y, Hisatsune A, Seki T, Shudo K, Katsuki H.
    • Journal Title

      J Neurosci Res.

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nitric oxide mediates selective degeneration of hypothalamic orexin neurons through dysfunction of protein disulfide isomerase2013

    • Author(s)
      Obukuro K, Nobunaga M, Takigawa M, Morioka H, Hisatsune A, Isohama Y, Shimokawa H, Tsutsui M, Katsuki H
    • Journal Title

      J Neurosci

      Volume: 33(31) Pages: 12557-68

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] MRI-based analysis of intracerebral hemorrhage in mice reveals relationship between hematoma expansion and the severity of symptoms2013

    • Author(s)
      Matsushita H, Hijioka M, Hisatsune A, Isohama Y, Iwamoto S, Terasawa H, Katsuki H
    • Journal Title

      PLoS One

      Volume: 8(7)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nitric oxide/soluble guanylyl cyclase signaling mediates depolarization-induced protection of rat mesencephalic dopaminergic neurons from MPP cytotoxicity2013

    • Author(s)
      Kurauchi Y, Hisatsune A, Isohama Y, Sawa T, Akaike T, Katsuki H
    • Journal Title

      Neuroscience

      Volume: 231 Pages: 206-15

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nitric oxide mediates selective degeneration of hypothalamic orexin neurons through dysfunction of protein disulfide isomerase.2013

    • Author(s)
      Obukuro K, Nobunaga M, Takigawa M, Morioka H, Hisatsune A, Isohama Y, Shimokawa H, Tsutsui M, Katsuki H.
    • Journal Title

      J Neurosci.

      Volume: 33(31) Issue: 31 Pages: 12557-68

    • DOI

      10.1523/jneurosci.0595-13.2013

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MRI-Based Analysis of Intracerebral Hemorrhage in Mice Reveals Relationship between Hematoma Expansion and the Severity of Symptoms2013

    • Author(s)
      松下 英明
    • Journal Title

      PLoS One

      Volume: e67691 Issue: 7 Pages: e67691-e67691

    • DOI

      10.1371/journal.pone.0067691

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nitric oxide/soluble guanylyl cyclase signaling mediates depolarization-induced protection of rat mesencephalic dopaminergic neurons from MPP+ cytotoxicity2013

    • Author(s)
      Kurauchi Y, Hisatsune A, Isohama Y, Sawa T, Akaike T and Katsuki H.
    • Journal Title

      Neurosci.

      Volume: 231 Pages: 206-215

    • DOI

      10.1016/j.neuroscience.2012.11.044

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] α7 Nicotinic acetylcholine receptor agonist attenuates neuropathological changes associated with intracerebral hemorrhage in mice2012

    • Author(s)
      Hijioka M, Matsushita H, Ishibashi H, Hisatsune A, Isohama Y, Katsuki H
    • Journal Title

      Neuroscience

      Volume: 222 Pages: 10-9

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Natural and synthetic retinoids afford therapeutic effects on intracerebral hemorrhage in mice2012

    • Author(s)
      Matsushita H, Hijioka M, Hisatsune A, Isohama Y, Shudo K, Katsuki H
    • Journal Title

      Eur J Pharmacol

      Volume: 683(1-3) Pages: 125-31

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Caffeic acid phenethyl ester protects nigral dopaminergic neurons via dual mechanisms involving haem oxygenase-1 and brain-derived neurotrophic factor2012

    • Author(s)
      Kurauchi Y, Hisatsune A, Isohama Y, Mishima S, Katsuki H
    • Journal Title

      Br J Pharmacol

      Volume: 166(3) Pages: 1151-68

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] α7 Nicotinic acetylcholine receptor agonist attenuates neuropathological changes associated with intracerebral hemorrhage in mice.2012

    • Author(s)
      Hijioka M, Matsushita H, Ishibashi H, Hisatsune A, Isohama Y, Katsuki H.
    • Journal Title

      Neuroscience.

      Volume: 222 Pages: 10-19

    • DOI

      10.1016/j.neuroscience.2012.07.024

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Natural and synthetic retinoids afford therapeutic effects on intracerebral hemorrhage in mice.2012

    • Author(s)
      Matsushita H, Hijioka M, Hisatsune A, Isohama Y, Shudo K, Katsuki H.
    • Journal Title

      Eur J Pharmacol.

      Volume: 683(1-3) Issue: 1-3 Pages: 125-131

    • DOI

      10.1016/j.ejphar.2012.03.023

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Caffeic acid phenethyl ester protects nigral dopaminergic neurons via dual mechanisms involving haem oxygenase-1 and brain-derived neurotrophic factor2012

    • Author(s)
      倉内祐樹
    • Journal Title

      British Journal of Pharmacology

      Volume: (in press) Issue: 3 Pages: 1151-1168

    • DOI

      10.1111/j.1476-5381.2012.01833.x

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Natural and synthetic retinoids afford therapeutic effects on intracerebral hemorrhage in mice.2012

    • Author(s)
      Matsushita H, Hijioka M, Hisatsune A, Isohama Y, Shudo K, Katsuki H.
    • Journal Title

      Eur J Pharmacol. Mar 23.

      Volume: .

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Orexin neurons in hypothalamic slice cultures are vulnerable to endoplasmic reticulum stress2011

    • Author(s)
      Michinaga S, Hisatsune A, Isohama Y, Katsuki H
    • Journal Title

      Neuroscience

      Volume: 190 Pages: 289-300

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effect of nicotine in a mouse model of intracerebral hemorrhage2011

    • Author(s)
      Hijioka M, Matsushita H, Hisatsune A, Isohama Y, Katsuki H
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 338(3) Pages: 741-9

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Orexin neurons in hypothalamic slice cultures are vulnerable to endoplasmic reticulum stress.2011

    • Author(s)
      Michinaga S, Hisatsune A, Isohama Y, Katsuki H.
    • Journal Title

      Neuroscience

      Volume: 190 Pages: 289-300

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effect of nicotine in a mouse model of intracerebral hemorrhage.2011

    • Author(s)
      Hijioka M, Matsushita H, Hisatsune A, Isohama Y, Katsuki H.
    • Journal Title

      J Pharmacol Exp Ther.

      Volume: 338(3) Pages: 741-749

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] High fat diet induces pathological change in hypothalamic orexin neurons2014

    • Author(s)
      延永瑞希、小袋加奈絵、倉内祐樹、久恒昭哲、関貴弘、筒井正人、香月博志
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      宮城県仙台市仙台国際センター, 他
    • Related Report
      2013 Final Research Report
  • [Presentation] Endogenous retinoid signaling after intracerebral hemorrhage in mice2014

    • Author(s)
      松下英明、肱岡雅宣、石橋勇人、阿南順平、倉内祐樹、久恒昭哲、関貴弘、首藤紘一、香月博志
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      宮城県仙台市仙台国際センター, 他
    • Related Report
      2013 Final Research Report
  • [Presentation] AQP5 expression enhances cytokine/chemokine expression by inflammatory stimuli in in airway epithelial cells2014

    • Author(s)
      坂本唯真、江川奈生、堀江一郎、久恒昭哲、香月博志、礒濱洋一郎
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      宮城県仙台市仙台国際センター, 他
    • Related Report
      2013 Final Research Report
  • [Presentation] High fat diet induces pathological change in hypothalamic orexin neurons2014

    • Author(s)
      延永 瑞希、小袋 加奈絵、倉内 祐樹、久恒 昭哲、関 貴弘、筒井 正人、香月 博志
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      宮城県仙台市仙台国際センター
    • Related Report
      2013 Annual Research Report
  • [Presentation] Endogenous retinoid signaling after intracerebral hemorrhage in mice2014

    • Author(s)
      松下 英明、肱岡 雅宣、石橋 勇人、阿南 順平、倉内 祐樹、久恒 昭哲、関 貴弘、首藤 紘一、香月 博志
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      宮城県仙台市仙台国際センター
    • Related Report
      2013 Annual Research Report
  • [Presentation] AQP5 expression enhances cytokine/chemokine expression by inflammatory stimuli in2014

    • Author(s)
      坂本 唯真、江川 奈生、堀江 一郎、久恒 昭哲、香月 博志、礒濱 洋一郎
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      宮城県仙台市仙台国際センター
    • Related Report
      2013 Annual Research Report
  • [Presentation] マウス炎症性ドパミンニューロン変性モデルにおけるフェルラ酸の神経保護効果の解析2013

    • Author(s)
      上松哲大、倉内祐樹、久恒昭哲、関貴弘、香月博志
    • Organizer
      第66回日本薬理学会西南部会
    • Place of Presentation
      福岡県福岡市福岡大学
    • Year and Date
      2013-11-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 内包領域での軸索障害を焦点とした脳内出血病態進行メカニズムの解析2013

    • Author(s)
      肱岡雅宜、松下英明、石橋勇人、久恒昭哲、礒濱洋一郎、香月博志
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      神奈川県横浜市パシフィコ横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] Mechanisms of retinoid-induced nNOS upregulation and neurite elongation in SH-SY5Y cells2013

    • Author(s)
      Tatsuya Fujibayashi, Yuki Kurauchi, Akinori Hisatsune, Yoichiro Isohama, Hiroshi Katsuki
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡県福岡市福岡国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of dexamethasone and reinoic acid receptor agnoist Am80 on acute inflammation following intracerebral hemorrhage in mice2013

    • Author(s)
      Hideaki Matsushita, Masanori Hijioka, Hayato Ishibashi, Akinori Hisatsune, Yoichiro Isohama, Koichi Syudo, Hiroshi Katsuki
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡県福岡市福岡国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] 内包領域での軸索障害を焦点とした脳内出血病態進行メカニズムの解析2013

    • Author(s)
      肱岡雅宜、松下英明、石橋勇人、久恒昭哲、礒濱洋一郎、香月博志
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] Mechanisms of retinoid-induced nNOS upregulation and neurite elongation in SH-SY5Y cells2013

    • Author(s)
      Tatsuya Fujibayashi, Yuki Kurauchi, Akinori Hisatsune, Yoichiro Isohama, Hiroshi Katsuki
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] Effects of dexamethasone and reinoic acid receptor agnoist Am80 on acute inflammation following intracerebral hemorrhage in mice2013

    • Author(s)
      Hideaki Matsushita, Masanori Hijioka, Hayato Ishibashi, Akinori Hisatsune, Yoichiro Isohama, Koichi Syudo, Hiroshi Katsuki
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] 脱シアル酸は、ミクログリアを活性化させる2012

    • Author(s)
      久恒昭哲,笠田高志,高橋周平,礒濱洋一郎,香月博志
    • Organizer
      第31回日本糖質学会
    • Place of Presentation
      鹿児島県鹿児島市鹿児島市民文化ホール
    • Related Report
      2013 Final Research Report
  • [Presentation] 脱シアル酸は、ミクログリアを活性化させる2012

    • Author(s)
      久恒昭哲,笠田高志,高橋周平,礒濱洋一郎,香月博志
    • Organizer
      第31回日本糖質学会
    • Place of Presentation
      鹿児島市民文化ホール
    • Related Report
      2012 Research-status Report
  • [Presentation] Involvement of bacterial sialidase in the development of bacterial meningitis2011

    • Author(s)
      Akinori Hisatsune, Takashi Kasada, Shuhei Takahashi, Yoichiro Isohama, Hiroshi Katsuki
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      米国ワシントンDC・コンベンションセンター
    • Related Report
      2011 Research-status Report
  • [Presentation] 細菌性シアリダーゼはミクログリアを活性化する2011

    • Author(s)
      久恒昭哲,笠田高志,高橋周平,礒濱洋一郎,香月博志
    • Organizer
      次世代を担う創薬・医療薬理シンポジウム2011
    • Place of Presentation
      北里大学薬学部(東京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] マウス炎症性ドパミンニューロン変性モデルにおけるフェルラ酸の神経保護効果の解析

    • Author(s)
      上松哲大、倉内祐樹、久恒昭哲、関貴弘、香月博志
    • Organizer
      第66回日本薬理学会西南部会
    • Place of Presentation
      福岡県福岡市福岡大学
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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