Analysis of neuroprotective effect of pigment epithelium derived factor

Research Project

Project/Area Number	23590111
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Biological pharmacy
Research Institution	Setsunan University (2012-2013) Kitasato University (2011)
Principal Investigator	YABE TAKESHI 摂南大学, 薬学部, 教授 (40239835)
Co-Investigator(Kenkyū-buntansha)	YAMADA Haruki 北里大学, 大学院感染制御科学府, 教授 (60096691)
Project Period (FY)	2011 – 2013
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000) Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	PEDF / グリア細胞 / グルタミン酸毒性 / 神経細胞死 / 神経新生 / グリア / 色素上皮由来因子 / 神経保護作用 / 神経系前駆細胞 / 脳虚血 / グルタミン酸トランスポーター
Research Abstract	Pigment epithelium-derived factor (PEDF) is a 50-kDa secreted glycoprotein and a non-inhibitory member of the serine protease inhibitor (SERPIN) gene family. PEDF is detected in a broad range of human tissues, including almost all brain areas, and has been shown to have strong neuroprotective properties for various types of neurons including cerebellar granule neurons, hippocampal neurons, striatal neurons, retinal neurons and spinal cord motor neurons.These observations raise thepossibility that application of PEDF may be helpful in designing new therapeutic strategies forneurodegenerative diseases. In this study. we tested neuroprptective effect of PEDF in vivo and in vitro.