Protein tyrosine phosphorylation in the neurovascular unit in cerebrovascular disease and therapeutic strategies
Project/Area Number |
23590114
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Biological pharmacy
|
Research Institution | Tokyo University of Pharmacy and Life Science |
Principal Investigator |
TAKAGI Norio 東京薬科大学, 薬学部, 教授 (50318193)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 脳梗塞 / 脳血管 / チロシンリン酸化 / 脳虚血 / 血液脳関門 |
Research Abstract |
This study sought to determine the role of protein tyrosine phosphorylation in the neurovascular unit after stroke. This study demonstrated that MPO-positive cells were increased in the surrounding brain capillaries after stroke, suggesting neutrophil infiltration. This infiltration was inhibited by src inhibitor. The increases in the levels of NOX subunit p67phox and COX-2 were also attenuated by src inhibitor. In addition, this study suggests that the pathophysiological alteration of the blood brain barrier after stroke may be regulated by tyrosine phosphorylation of PDGFR-beta in the pericytes.
|
Report
(4 results)
Research Products
(2 results)