Study of roles of endogenous hydrogen sulfide in stomach with mucosal injury

• Project/Area Number: 23590122
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Kinki University
• Principal Investigator: SEKIGUCHI Fumiko 近畿大学, 薬学部, 准教授 (90271410)
• Co-Investigator(Kenkyū-buntansha): KAWABATA Atsufumi 近畿大学, 薬学部, 教授 (20177728)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 硫化水素合成酵素 / 胃癌細胞増殖 / T型カルシウムチャネル / 抗アポトーシス因子 / 胃粘膜傷害 / 細胞増殖 / アポトーシス / 酵素 / 細胞・組織 / シグナル伝達

Research Abstract

In human gastric cancer-derived AGS cells, our findings suggest that endogenous hydrogen sulfide (H2S) produced by cystathionine-gamma-lyase (CSE), one of H2S-forming enzymes in the mammalian body, accelerates the proliferation of AGS cells. The effects of H2S may be mediated, in part, by increase in function of Cav3.2 T-type calcium channels and upregulation of anti-apoptotic proteins, Bcl-2 and Bcl-xL, via activation of NF-kappaB caused by endogenous H2S. These pathways can be expected to be effective targets for treatment of gastric cancer.

Research Products

• [Journal Article] Endogenous Hydrogen Sulfide Enhances Cell Proliferation of Human Gastric Cancer AGS Cells (2016)
  • Author(s): Fumiko Sekiguchi, Teruki Sekimoto, Ayaka Ogura and Atsufumi Kawabata
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 39 Issue: 5 Pages: 887-890
  • DOI: 10.1248/bpb.b15-01015
  • NAID: 130005149260
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed / Open Access
• [Journal Article] Endogenous hydrogen sulfide contributes to cell proliferation in gastric cancer cells (2012)
  • Author(s): Fumiko Sekiguchi, Teruki Sekimoto, Atsufumi Kawabata
  • Journal Title: J Pharmacol. Sci Volume: vol. 118 (Suppl. 1) Pages: 122-122
• [Presentation] ヒト胃癌由来AGS細胞における内因性硫化水素の細胞増殖への関与とその下流シグナルの解析 (2014)
  • Author(s): 小椋彩加、関本晃己、関口富美子、川畑篤史
  • Organizer: 第125回日本薬理学会近畿部会
  • Place of Presentation: 岡山(ポスター発表)
  • Year and Date: 2014-06-20
• [Presentation] ヒト胃癌由来AGS細胞における内因性硫化水素の細胞増殖への関与とその下流シグナルの解析 (2014)
  • Author(s): 小椋彩加、関本晃己、関口富美子、川畑篤史
  • Organizer: 第125回日本薬理学会近畿部会
  • Place of Presentation: 岡山コンベンションセンター（岡山市）
• [Presentation] 胃癌細胞における内因性硫化水素の細胞増殖促進作用について (2012)
  • Author(s): 関本晃己、関口富美子、川畑篤史
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌(ポスター発表)
• [Presentation] Roles of endogenous hydrogen sulfide in prolife- ration of gastric cancer cells (2012)
  • Author(s): Fumiko Sekiguchi, Teruki Sekimoto, Ayaka Ogura, Atsufumi Kawabata
  • Organizer: 7th International Symposium on Cell/Tissue Injury and Cyotoprotection/Organo- protection
  • Place of Presentation: Honolulu(口頭発表)
• [Presentation] 胃癌細胞において内因性に産生される硫化水素は癌細胞増殖に関与する (2012)
  • Author(s): 関口富美子、関本晃己、川畑篤史
  • Organizer: 第85回日本薬理学会年会
  • Place of Presentation: 京都(口頭発表)
• [Presentation] Roles of endogenous hydrogen sulfide in proliferation of gastric cancer cells (2012)
  • Author(s): Sekiguchi, F., Sekimoto, T., Ogura, A., Kawabata, A.
  • Organizer: 7th International Symposium on Cell/Tissue Injury and Cyotoprotection/Organoprotection
  • Place of Presentation: Honolulu, Hawaii, USA
• [Presentation] 胃癌細胞において内因性に産生される硫化水素は癌細胞増殖に関与する．
  • Author(s): 関口富美子、関本晃己、川畑篤史．
  • Organizer: 第85回日本薬理学会年会
  • Place of Presentation: 国立京都国際会館（京都）
• [Presentation] 胃癌細胞における内因性硫化水素の細胞増殖促進作用について．
  • Author(s): 関本晃己、関口富美子、川畑篤史．
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 北海道大学（札幌）
• [Remarks]
  • URL: http://www.phar.kindai.ac.jp/byoutai/index.files/byoutai.htm