Dysbindin-1, a schizophrenia-related molecule, interacts with cyclin D1
| Project/Area Number |
23590124
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Institute for Developmental Research, Aichi Human Service Center |
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Principal Investigator |
ITO Hidenori 愛知県心身障害者コロニー発達障害研究所, 神経制御学部, 主任研究員 (40311443)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 統合失調症 / dysbindin / サイクリン / サイクリンD / 神経細胞 / 歯状回 / 脳神経疾患 / 細胞周期 / 核外移行 |
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| Outline of Final Research Achievements |
Dysbindin-1 is now widely accepted as a potential schizophrenia susceptibility gene. However, cellular functions of dysbindin-1 are largely unknown. To reveal novel functions of dysbindin-1, we tried to identify a new binding partner. We consulted with the protein interaction database and found cyclin D3 as a possible binding partner for dysbindin-1. Immunoprecipitation analysis revealed that dysbindin-1A preferentially complexes with cyclin D1 among various dysbindin-1 isoforms and D-type cyclins. Dysbindin-1 and cyclin D1 in NIH3T3 cells partially co-localized at the cytosol and the nucleus in a cell cycle progression-dependent manner. Co-expression of dysbindin-1A transferred the nuclear cyclin D1 to the cytosolic fraction in many cells. These results indicate that dysbindin-1 may control the cell cycle progression in concert with cyclin D1.
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Report
(5 results)
Research Products
(43 results)
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[Journal Article] SIL1, a causative cochaperone gene of Marinesco-Sjogren syndrome, plays an essential role in establishing the architecture of the developing cerebral cortex.2014
Author(s)
Hamada N, Inaguma Y, Tabata H, Iwamoto I, Mizuno M, Nishimura YV, Ito H, Morishita R, Suzuki M, Ohno K, Kumagai T, Nagata K.
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Journal Title
EMBO Mol Med.
Volume: 6
Issue: 3
Pages: 414-29
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Cell biological characterization of a multidomain adaptor protein, ArgBP2, in epithelial NMuMG cells, and identification of a novel short isoform.2012
Author(s)
Murase K, Ito H, Kanoh H, Sudo K, Iwamoto I, Morishita R, Soubeyran P, Seishima M, Nagata K.
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Journal Title
Med Mol Morphol.
Volume: 45
Issue: 1
Pages: 22-28
DOI
NAID
Related Report
Peer Reviewed
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