Antimicrobial activity and synthesis of siderophore produced by Acinetobacter

• Project/Area Number: 23590129
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Drug development chemistry
• Research Institution: Okayama University
• Principal Investigator: TAKEUCHI Yasuo 岡山大学, 医歯(薬)学総合研究科, 教授 (00163387)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
• Keywords: アシネトバクター / アシネトバクチン / 全合成 / 構造訂正 / 抗ＭＲＳＡ / 転位反応 / 類縁体合成 / 構造決定 / 構造活性相関 / 抗菌作用

Research Abstract

I conducted a study of the chemical substance called Acinetobactine that Acinetobacter bacteria that causes the infection is produced. By this study, it was found that the reported structure of the compound was mistake. Based on the development of this new structure, we worked on the development of drugs effective against resistant bacteria.

Research Products

• [Journal Article] (2013)
  • Author(s): Morimoto N., Y, Takeuchi, Nishina Y
  • Journal Title: Journal of Molecular Catalysis A : Chemical Pages: 31-37
  • Peer Reviewed
• [Journal Article] (2013)
  • Author(s): Suzuki H., Yoshioka S., Igesaka A., Nishioka H., Takeuchi Y
  • Journal Title: Tetrahedron Volume: 69(31) Pages: 6399-6403
  • Peer Reviewed
• [Journal Article] (2013)
  • Author(s): Morimoto N., Yamamoto S., Takeuchia Y., Nishina Y
  • Journal Title: RSC Advances Volume: 3(36) Pages: 15608-15612
  • Peer Reviewed
• [Journal Article] (2013)
  • Author(s): Shirasaki Y., Kamino S., Tanioka M., Watanabe K., Takeuchi Y., Komeda S., Enomoto Sh
  • Journal Title: Chemistry An Asian Journal Volume: 8(11) Pages: 2609-2613
  • Peer Reviewed
• [Journal Article] (2013)
  • Author(s): Matsukihira T., Kida T., HidakaS. K., Sagaa, Takemura M., Yonoki A., Nishimori T., Horino Y., Harayama T., Takeuchi Y., Abe H
  • Journal Title: HETEROCYCLES Volume: 87(12) Pages: 2555-2565
  • Peer Reviewed
• [Journal Article] (2012)
  • Author(s): Suzuki H., Nishioka H., Takeuchi Y
  • Journal Title: Tetrahedron Letters Volume: 53(28) Pages: 3686-3688
  • Peer Reviewed
• [Journal Article] (2012)
  • Author(s): Abe H., Matsukihira T., Fukumoto T., Horino Y., Takeuchi Y., Harayama T
  • Journal Title: Heterocycles Volume: 84 Pages: 323-326
  • Peer Reviewed
• [Journal Article] (2012)
  • Author(s): Abe H., Kawai T., Komatsu Y., Kamimura M., Takeuchi Y., Horino Y
  • Journal Title: Heterocycles Volume: 86(1) Pages: 785-789
  • Peer Reviewed
• [Journal Article] (2011)
  • Author(s): Shioe K., Sahara Y., Horino Y., Harayama T., Takeuchi Y., Abe H
  • Journal Title: Tetrahedron Volume: 67 Pages: 1960-1970
  • Peer Reviewed
• [Journal Article] (2011)
  • Author(s): Inoue S., Nishioka H., Abe H., Harayama T., Takeuchi Y
  • Journal Title: Synthesis Volume: 11 Pages: 1705-1710
  • Peer Reviewed
• [Journal Article] (2011)
  • Author(s): Nishioka H., Uesugi K., Ueda N., Kondo Y., Tsuji M., Abe H., Harayama T., Hamasaki T., Baba M., Takeuchi Y
  • Journal Title: Chem. Pharm. Bull Volume: 59(8) Pages: 1075-1076
  • Peer Reviewed
• [Journal Article] (2011)
  • Author(s): Serban G., Abe H., Takeuchi Y
  • Journal Title: Heterocycles Volume: 83(9) Pages: 1989-2000
  • Peer Reviewed
• [Presentation] アシネトバクチン中間類縁体の合成 (2013)
  • Author(s): 田鍋智弘(岡山大院医歯薬)、大西浩文(岡山大薬)、竹内靖雄(岡山大院医歯薬)
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
  • Year and Date: 2013-03-30
• [Presentation] アシネトバクチン中間類縁体の合成 （30pmA-458）
  • Author(s): 田鍋 智弘 1 ,大西 浩文 2 ,竹内 靖雄
  • Organizer: 日本薬学会第１３３年会（横浜）
  • Place of Presentation: パシフィコ横浜