| Project/Area Number |
23590130
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OTSUKA Hideaki 広島大学, 医歯薬保健学研究院, 名誉教授 (00107385)
SUGIMOTO Sachiko 広島大学, 医歯薬保健学研究院, 講師 (60549012)
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| Co-Investigator(Renkei-kenkyūsha) |
OKA Tomoichiro 国立感染症研究所, ウイルス第2部, 主任研究官 (50356242)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 生物活性物質 / 配糖体 / トリテルペン / 抗インフルエンザ活性 / 亜熱帯植物 / ウイルス / 化学構造解析 / 活性試験 |
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| Research Abstract |
Phytochemical investigation of subtropical plants (Microtropis japonica, Stewartia pseudocamellia, Cananga odorata, Ardisia quinquegona, and Scolopia oldhamii) and a marine sponge (phyllospongia sp.) revealed 14 new triterpenes, six saponins, three lignans, 11 benzoquinones together with three triterpens, and 14 scalarene-type sesterterpenes, respectively.The chemical structure of these new compounds were elucidated mainly by spectroscopic analysis. The anti-influenza virus activity and cytotoxicity were also evaluated. Part of these results has been published in several international research journals.
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