Phytochemical investigation for anti-viral compounds from Okinawan subtropical plants
| Project/Area Number |
23590130
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Drug development chemistry
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OTSUKA Hideaki 広島大学, 医歯薬保健学研究院, 名誉教授 (00107385)
SUGIMOTO Sachiko 広島大学, 医歯薬保健学研究院, 講師 (60549012)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
OKA Tomoichiro 国立感染症研究所, ウイルス第2部, 主任研究官 (50356242)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
|---|
| Keywords | 生物活性物質 / 配糖体 / トリテルペン / 抗インフルエンザ活性 / 亜熱帯植物 / ウイルス / 化学構造解析 / 活性試験 |
|---|
| Research Abstract |
Phytochemical investigation of subtropical plants (Microtropis japonica, Stewartia pseudocamellia, Cananga odorata, Ardisia quinquegona, and Scolopia oldhamii) and a marine sponge (phyllospongia sp.) revealed 14 new triterpenes, six saponins, three lignans, 11 benzoquinones together with three triterpens, and 14 scalarene-type sesterterpenes, respectively.The chemical structure of these new compounds were elucidated mainly by spectroscopic analysis. The anti-influenza virus activity and cytotoxicity were also evaluated. Part of these results has been published in several international research journals.
|
Report
(4 results)
Research Products
(20 results)
