| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
Nafuredin-gamma, converted from nafuredin as a fungal metabolite under mild basic conditions, demonstrates inhibitory activity and selectivity against complex I of Ascaris suum. These compounds have unique and useful biological activities; however, the conjugated diene moieties included in the structure are highly unstable in the presence of oxygen. To solved this problem, stable nafuredin-gamma derivatives with non-conjugated (E)-olefins in the side chain moiety designed and synthesized. These derivatives showed moderate complex I inhibitory activities and high stabilities in air .
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