Synthesis of new compounds inducing potent and selective differentiation from neural stem cells into neurons
| Project/Area Number |
23590136
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Shibaura Institute of Technology (2012-2013)
Yokohama College of Pharmacy (2011) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 脳神経幹細胞 / ニューロン / 分化誘導 / ビタミンK / 誘導体 / 合成 / メナキノン－４ / 再生医療 / 脳神経変性疾患 / アルツハイマー病 / イソプレノイド / 分化誘導活性 |
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| Research Abstract |
We synthesized new compounds, which have selective differentiation activity from neuronal progenitor cells into neurons in vitro. The result of the assay exhibited vitamin K analogues introduced m-methylphenyl group at the omega-terminal position had the most potent activity, which was twice as much as control. This finding indicated that it will be possible to obtain much more potent compounds with modification of vitamin K. Now we are going to investigate the functional mechanism of the compounds.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Structure-activity relationship of novel menaquinone-4 analogues : Modification of the side chain affects their biological activities2012
Author(s)
Suhara, Y.; Hanada, N.; Okitsu, T.; Sakai, M.; Watanabe, M.; Nakagawa, K.; Wada, A.; Takeda, K.; Takahashi, K.; Tokiwa, H.; Okano, T
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Journal Title
J. Med. Chem
Volume: 55
Issue: 4
Pages: 1553-1558
DOI
Related Report
Peer Reviewed
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