| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
We synthesized new compounds, which have selective differentiation activity from neuronal progenitor cells into neurons in vitro. The result of the assay exhibited vitamin K analogues introduced m-methylphenyl group at the omega-terminal position had the most potent activity, which was twice as much as control. This finding indicated that it will be possible to obtain much more potent compounds with modification of vitamin K. Now we are going to investigate the functional mechanism of the compounds.
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