Design, Synthesis and Antibacterial Activity of Novel Pleuromutilin Derivatives
| Project/Area Number |
23590139
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Osaka Ohtani University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 抗生物質 / 多剤耐性菌 / リューロムチリン / 創薬研究 / 創製研究 / 天然物 / リューロムチリン誘導体 |
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| Outline of Final Research Achievements |
It is increasing the emergence of drug-resistant bacterial strains that are resistant to marketed antibacterial agents, and increasingly has be reported that death caused by drug-resistant strains. Thus, with the aim of producing new antibacterial agents which have effective for multiple-drug-resistant bacteria, I have achieved study on the synthesis of unique compound which have been designed based on the diterpenoid preuromutilin, was isolated from basidiomycete species, and have evaluated their antibacterial activities. As a consequence, I found compounds that show equal potent antibacterial activities against S. aureus FDA209P and S. aureus KMP9, and also have excellent water-soluble that can be developed as an injection.
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Report
(5 results)
Research Products
(2 results)
