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Analysis of p57KIP2's physiological role dependent on fat vitamines

Research Project

Project/Area Number 23590153
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Environmental pharmacy
Research InstitutionHoshi University

Principal Investigator

TAKAHASHI Katsuhiko  星薬科大学, 薬学部, 准教授 (80307066)

Co-Investigator(Kenkyū-buntansha) IMAI Masahiko  星薬科大学, 医薬品化学研究所, 助教 (40507670)
TAKAHASHI Noriko  星薬科大学, 医薬品化学研究所, 教授 (50277696)
Co-Investigator(Renkei-kenkyūsha) AMANO Hitoshi  昭和大学, 歯学部, 准教授 (90212571)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords脂溶性ビタミン / 骨代謝 / 胎盤 / 細胞周期 / アミノ酸トランスポーター / p57Kip2 / 骨芽細胞 / 核内受容体 / p57Kip2 / 脂溶性生理活性物質 / ビタミンA / ビタミンD / 長鎖不飽和脂肪酸
Research Abstract

A CDK inhibitor, p57Kip2, might be one of the molecules for osteogenesis, because p57-ablated mice displayed delay of bone formation. So, we assumed that p57 could regulate the bioactivities of the certain vitamins or hormones for bone formation. Here we have found out that p57 bound VDR, vitamine D3 receptor, and was necessary for VDR's activity, which is the transcription factor. And p57 KO mice also displayed placentamegaly with trophoblastic displasia.
p57 affected on the expression levels and cellular localization of ASCT2, which acts for the cell fusion in trophoblast-differentiation. Now we are examining the mechanism of the p57's activity on ASCT2 on placentamegaly.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (21 results)

All 2014 2013 2012 2011 Other

All Journal Article (8 results) (of which Peer Reviewed: 7 results) Presentation (13 results)

  • [Journal Article] Molecular mechanism of 9-cis-retinoic acid inhibition of adipogenesis in 3T3-L1 cells2013

    • Author(s)
      C. Sagara, K. Takahashi, H. Kagechika, and N. Takahashi
    • Journal Title

      Biochem Biophys Res Commun

      Volume: Vol.433 Pages: 102-107

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mechanism of 9-cis-retinoic acid inhibition of adipogenesis in 3T3-L1 cells.2013

    • Author(s)
      C. Sagara, K. Takahashi, H. Kagechika, and N. Takahashi
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 433 Pages: 102-107

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p53 retards cell-growth and suppresses etoposide-induced apoptosis in Pin1-deficient mouse embryonic fibroblasts2012

    • Author(s)
      K. Shimazaki, T. Uchida, A. Komine, and K. Takahashi
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: Vol.422 Pages: 133-138

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] p53 retards cell-growth and suppresses etoposide-induced apoptosis in Pin1-deficient mouse embryonic fibroblasts.2012

    • Author(s)
      K. Shimazaki, T. Uchida, A. Komine, and K. Takahashi
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: Vol.422 Pages: 133-138

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Covalent binding of retinoic acid to cytokeratins 16 and 10 accompanies its action in mouse skin tissues2011

    • Author(s)
      N. Takahashi, T. Ohba, M. Imai, Y. Sasaki, T. Kumaoka, K. Takahashi, and Y. Fujiu
    • Journal Title

      FASEB J

      Volume: Vol.25 Pages: 951-955

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rab3a and Rab27b Expression in Nonfunctioning Pituitary Adenomas2011

    • Author(s)
      A. Sasaki, K. Takahashi, G. Yamamoto, Y. Tsunoda, T. Abe, and T. Tachikawa
    • Journal Title

      Showa Univ. J. Med. Sci

      Volume: Vol.22 Pages: 183-192

    • NAID

      130004566523

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Covalent binding of retinoic acid to cytokeratins 16 and 10 accompanies its action in mouse skin tissues.2011

    • Author(s)
      TAKAHASHI N, OHBA T, IMAI M, SASAKI Y, KUMAOKA T, TAKAHASHI K, FUJIU Y.
    • Journal Title

      FASEB J.

      Volume: 25 Pages: 951-955

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Rab3a and Rab27b Expression in Nonfunctioning Pituitary Adenomas.2011

    • Author(s)
      SASAKI, A., TAKAHASHI, K., YAMAMOTO, G., TSUNODA, Y., ABE, T., AND TACHIKAWA, T
    • Journal Title

      Showa Univ. J. Med. Sci

      Volume: 22 Pages: 183-192

    • NAID

      130004566523

    • Related Report
      2011 Research-status Report
  • [Presentation] アミノ酸輸送体Asct2を標的とした脂肪蓄積抑制効果の検討2014

    • Author(s)
      高橋勝彦, 他
    • Organizer
      平成25年度学術研究振興資金研究成果報告会
    • Place of Presentation
      東京
    • Year and Date
      2014-02-17
    • Related Report
      2013 Final Research Report
  • [Presentation] レチノイン酸作用機序に基づく抗肥満ターゲットとしてのアミノ酸トランスポーター・ASCT2の可能性2013

    • Author(s)
      高橋勝彦, 他
    • Organizer
      平成24年度学術研究振興資金研究成果報告会
    • Place of Presentation
      東京
    • Year and Date
      2013-02-28
    • Related Report
      2013 Final Research Report
  • [Presentation] p53によるPin1欠損細胞の増殖・細胞死制御の検討2013

    • Author(s)
      高橋勝彦, 他
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] p53-Pin1ネットワークの生理的意義とエネルギー代謝への関与の可能性2012

    • Author(s)
      高橋勝彦
    • Organizer
      東北大学農学部第三回タンパク質研究会
    • Place of Presentation
      仙台
    • Year and Date
      2012-06-05
    • Related Report
      2013 Final Research Report
  • [Presentation] レチノイド受容体RXRへのp57^<Kip2>の関与の検討2012

    • Author(s)
      高橋勝彦, 他
    • Organizer
      オープンリサーチセンター整備事業研究成果報告会
    • Place of Presentation
      東京
    • Year and Date
      2012-02-23
    • Related Report
      2013 Final Research Report
  • [Presentation] 胎盤栄養膜細胞におけるレチノイン酸依存的PKA活性化の解析2011

    • Author(s)
      高橋勝彦, 他
    • Organizer
      オープンリサーチセンター整備事業研究成果中間報告会
    • Place of Presentation
      東京
    • Year and Date
      2011-02-24
    • Related Report
      2013 Final Research Report
  • [Presentation] Involvement of p57^<KIP2>in hydrophobic vitamin receptor of human choriocarcinoma BeWo cells2011

    • Author(s)
      Katsuhiko Takahashi, 他
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 成熟脂肪細胞に与えるレチノイドの影響日本レチノイド研究会2011

    • Author(s)
      高橋勝彦, 他
    • Organizer
      第22回学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Association of p57Kip2 with fat-soluble vitamin nuclear receptors in placent2011

    • Author(s)
      高橋 勝彦,高橋 典子
    • Organizer
      日本生化学会
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Presentation] アミノ酸輸送体Asct2を標的とした脂肪蓄積抑制効果の検討

    • Author(s)
      高橋勝彦、内田奈津美、北中千束、高橋典子
    • Organizer
      平成25年度 学術研究振興資金 研究成果報告会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] p53 retards cell-growth and suppresses etoposide-induced apoptosis in Pin1-deficient mouse embryonic fibroblasts

    • Author(s)
      高橋勝彦 田村隆裕 内田隆史
    • Organizer
      日本薬学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] レチノイン酸作用機序に基づく抗肥満ターゲットとしてのアミノ酸トランスポーター・ASCT2の可能性

    • Author(s)
      高橋勝彦 内田奈津美 北中千智 高橋典子
    • Organizer
      星薬科大・学術研究振興資金研究成果報告会
    • Place of Presentation
      品川、東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 成熟脂肪細胞に与えるレチノイドの影響

    • Author(s)
      高橋 勝彦,高木 翼,相良 千晶,影近 弘之,高橋 典子
    • Organizer
      レチノイド研究会
    • Place of Presentation
      日大講堂、東京
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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