Modification of organometallic compound cytotoxicity by incorporated metal atoms and molecular mechanisms underlying the toxicity
| Project/Area Number |
23590156
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Toho University (2013)
Hokuriku University (2011-2012) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NOBUKUNI Yoshitaka 広島大学, 原爆放射線医科学研究所, 准教授 (80295641)
YASUIKE Shuji 愛知学院大学, 薬学部, 教授 (10230210)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 細胞毒性 / ビスマス / アンチモン / ハイブリッド分子 / 有機金属化合物 / ジーントラップ法 / 血管内皮細胞 / CHO細胞 / 有機化学物質 / 毒性 / 内皮細胞 |
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| Research Abstract |
We have already found that organobismuth compounds often exhibit cytotoxicity in vascular endothelial cells. The purpose of the present study was to obtain cell clones that are tolerant to the toxic organobismuth compounds (PMTABi, DAPBi, and TDPBi) form a random gene trap insertional mutants library of CHO cells, to investigate candidate genes involved in the tolerance of the cells, and to clarify the molecular targets of the cytotoxicity of the organobismuth compounds. We succeeded to obtain 97 clones of the tolerant cells and identified candidate genes involved in the tolerance of the cells.
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Report
(4 results)
Research Products
(18 results)
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[Presentation] 有機カルコゲン化合物の細胞毒性2013
Author(s)
橋谷珠世,岡崎貴大,郡久美子,山本千夏,藤原泰之,信國好俊,栗田城治,鍜冶利幸
Organizer
フォーラム2013:衛生薬学・環境トキシコロジー
Place of Presentation
福岡
Year and Date
2013-09-13
Related Report
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