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Search for agonists of new plasma membrane estrogen receptors and their anti-stress effects

Research Project

Project/Area Number 23590159
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Environmental pharmacy
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

TAKAHASHI Kojiro  産業医科大学, 医学部, 非常勤講師 (70389477)

Co-Investigator(Kenkyū-buntansha) YANAGIHARA Nobuyuki  産業医科大学, 医学部, 教授 (80140896)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsカテコールアミン生合成 / カテコールアミン分泌 / 抗ストレス効果 / 細胞膜エストロゲン受容体 / 受容体作動薬 / 植物性エストロゲン / 植物フラボノイド / ノルアドレナリントランスポーター / 植物エストロゲン / 副腎髄質 / ダイゼイン / ノビレチン / チロシン水酸化酵素 / 分子クローニング / ゲニステイン / カテコールアミン / 抗ストレス作用
Research Abstract

The agonists of plasma membrane estrogen receptors were investigated. Daidzein and genistein, soy isoflavones, and resveratrol, a grape polyphenol, inhibited the specific binding of [3H]17beta-estradiol to plasma membranes isolated from bovine adrenal medulla. These phytoestrogens and a plant flavonoid, nobiletin, inhibited catecholamine synthesis and secretion induced by acetylcholine in cultured bovine adrenal medullary cells. Resveratrol also affected the function of noradrenaline transporter in SK-N-SH cells (human neuroblastoma cell line). These results suggest that phytoestrogens and some plant flavonoids have protective effects against stresses.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (89 results)

All 2014 2013 2012 2011 Other

All Journal Article (23 results) (of which Peer Reviewed: 22 results) Presentation (64 results) Book (2 results)

  • [Journal Article] Inverse correlation between the standard deviation of R-R intervals in the supine position and the simplified menopausal index in women with climacteric symptoms2014

    • Author(s)
      Yanagihara N., Seki M., Nakano M., Hachisuga T., Goto Y
    • Journal Title

      Menopause

      Volume: 21(in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] New Insights Into the Pharmacological Potential of Plant Flavonoids in the Catecholamine System2014

    • Author(s)
      Yanagihara N., Zhang H., Toyohira Y., Takahashi K., Ueno S., Tsutsui M., Takahashi K
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 124 Issue: 2 Pages: 123-128

    • DOI

      10.1254/jphs.13R17CP

    • NAID

      130003391488

    • ISSN
      1347-8613, 1347-8648
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of food deprivation on the hypothalamic feeding-regulating peptides gene expression in serotonin depleted rats2014

    • Author(s)
      Yoshimura M., Hagimoto M., Matsuura T., Ohkubo J., Ohno M., Maruyama T., Ishikura T., Hashimoto H., Kakuma T., Yoshimatsu H., Terawaki K., Uezono Y., Toyohira Y., Yanagihara N., Ueta Y
    • Journal Title

      J Physiol Sci

      Volume: 64 Issue: 2 Pages: 97-104

    • DOI

      10.1007/s12576-013-0296-1

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Selective Estrogen Receptor Modulators on Plasma Membrane Estrogen Receptors and Catecholamine Synthesis and Secretion in Cultured Bovine Adrenal Medullary Cells2014

    • Author(s)
      Inagaki H., Toyohira Y., Takahashi K., Ueno S., Obara G, Kawagoe T., Tsutsui M., Hachisuga T., Yanagihara N
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 124 Issue: 1 Pages: 66-75

    • DOI

      10.1254/jphs.13155FP

    • NAID

      130003382627

    • ISSN
      1347-8613, 1347-8648
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stimulatory effect of nobiletin, a citrus polymethoxy flavone, on catecholamine synthesis through Ser19 and Ser40 phosphorylation of tyrosine hydroxylase in cultured bovine adrenal medullary cells2014

    • Author(s)
      Zhang H., Yanagihara N., Toyohira Y., Takahashi K., Inagaki H., Li X., Tsutsui M., Takahashi K
    • Journal Title

      Naunyn-Schmiedeberg’s Arch of Pharmacol

      Volume: 387 Issue: 1 Pages: 15-22

    • DOI

      10.1007/s00210-013-0916-6

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antagonism of cortex periplocae extract-induced catecholamines secretion by Panax notoginseng saponins in cultured bovine adrenal medullary cell by drug combinations2013

    • Author(s)
      Guo H., Mao H., Zhang H., Fan G., Li G., Zhou K., Zhu Y., Yanagihara N., Gao X.
    • Journal Title

      J Ethenopharmacol

      Volume: 147 Issue: 2 Pages: 447-455

    • DOI

      10.1016/j.jep.2013.03.036

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nitric oxide synthase and heart failure-Lesson from genetically manipulated mice2013

    • Author(s)
      Shibata K., Shimokawa H., Yanagihara N., Otsuji Y., Tsutsui M
    • Journal Title

      J UOEH

      Volume: 35 Pages: 147-158

    • NAID

      110009615291

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-Term Treatment With San’o-Shashin-To, a Kampo Medicine, Markedly Ameliorates Cardiac Ischemia-Reperfusion Injury in Ovariectomized Rats via the Redox-Dependent Mechanism2013

    • Author(s)
      Sakanashi M, Matsuzaki T, Noguchi K, Nakasone J, Sakanashi M, Uchida T, Kina-Tanada M, Kubota H, Arakaki K, Tanimoto A, Yanagihara N, Sakanashi M, Ohya Y, Masuzaki H, Ishiuchi S, Sugahara K, Tsutsui M
    • Journal Title

      Circulation Journal

      Volume: 77 Issue: 7 Pages: 1827-1837

    • DOI

      10.1253/circj.CJ-12-1434

    • NAID

      10031173765

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pentazocine Inhibits Norepinephrine Transporter Function by Reducing its Surface Expression in Bovine Adrenal Medullary Cells2013

    • Author(s)
      Obara G., Toyohira Y., Inagaki H., Takahashi K., Horishita T., Ueno S., Tsutsui M., Yanagihara N
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 121 Issue: 2 Pages: 138-147

    • DOI

      10.1254/jphs.12164FP

    • NAID

      10031156943

    • ISSN
      1347-8613, 1347-8648
    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibition by Pregnenolone Sulphate, a Metabolite of the Neurosteroid Pregnenolone, of Voltage-Gated Sodium Channels Expressed in <I>Xenopus</I> Oocytes2012

    • Author(s)
      Horishita T., Ueno S., Yanagihara N., Sudo Y., Uezono Y., Okura D., Sata T
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 120 Issue: 1 Pages: 54-58

    • DOI

      10.1254/jphs.12106SC

    • NAID

      10031071961

    • ISSN
      1347-8613, 1347-8648
    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Stimulation of norepinephrine transporter function by fasudil, a Rho kinase inhibitor, in cultured bovine adrenal medullary cells2012

    • Author(s)
      Satoh N., ToyohiraY., Itoh H., Zhang H., Ueno S., Tsutsui M., Takahashi K., Yanagihara N.
    • Journal Title

      Naunyn-Schmiedeberg’s Archives of Pharmacology

      Volume: 385 Issue: 9 Pages: 921-931

    • DOI

      10.1007/s00210-012-0773-8

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 習慣飲酒の更年期障害症候群患者に対する加味逍遥散の有用性2012

    • Author(s)
      石明寛、広渡加奈子、椎葉美代子、蜂須賀徹、土岐尚之、柳原延章、石政維、上田恵、吉武英憲
    • Journal Title

      Science of Kampo Medicine

      Volume: 36 Pages: 55-59

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 勤労女性における更年期障害症候群患者の飲酒動態について2012

    • Author(s)
      石 明寛、廣渡加奈子、椎葉美代子、蜂須賀 徹、柳原延章、土岐尚之、石 政維、上田 恵、吉武英憲
    • Journal Title

      産婦人科の実際

      Volume: 61 Pages: 497-502

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] なぜ服薬指導の場におけるコミュニケーション教育を重視するのかー医師の立場から2012

    • Author(s)
      柳田俊彦、安西尚彦、入江徹美、岩本隆宏、柳原延章、中野重行、村上学
    • Journal Title

      薬局

      Volume: 63 Pages: 145-149

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Influence of work shift on glutamic acid and gamma-aminobutyric acid (GABA): Evaluation with proton magnetic resonance spectroscopy at 3T2011

    • Author(s)
      Kakeda S., Korogi Y., Moriya J., Ohnari N., Sato T., Ueno S., Yanagihara N., Harada M., Matsuda T
    • Journal Title

      Psychiatric Research : Neuroimaging

      Volume: 192 Pages: 55-59

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle2011

    • Author(s)
      Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itoh S, Takamoto I, Sasako T, Kumagai K, Kawai T, Hashimoto S, Kobayashi T, Sato M, Tokuyama K, Nishimura S, Tsunoda M, Ide T, Murakami K, Yamazaki T, EzakiO, Kawamura K, Masuda H, Moroi M, Sugi K, Oike Y, Shimokawa H, Yanagihara N, Tsutsui M, Terauchi Y, Tobe K, Nagai R, Kamata K, Inoue K, Kodama T, Ueki K, Kadowaki T
    • Journal Title

      Cell Metab

      Volume: 13(3) Issue: 3 Pages: 294-307

    • DOI

      10.1016/j.cmet.2011.01.018

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Crucial vasculoprotective role of the whole nitric oxide synthase system in vascular lesion formation in mice : Involvement of bone marrow-derived cells2011

    • Author(s)
      Furuno Y., Morishita T., Toyohira Y., Yamada S., Ueno S., Morisada N., Sugita K., Noguchi K., Sakanashi M., Miyata H., Tanimoto A., Sasaguri Y., Shimokawa H., Otsuji Y., Yanagihara N., Tamura M., Tsuttsui M
    • Journal Title

      Nitric Oxide

      Volume: 25 Issue: 3 Pages: 350-359

    • DOI

      10.1016/j.niox.2011.06.007

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dendritic cell-derived dopamine induces IL-6-dependent Th17 polarization in rheumatoid arthritis2011

    • Author(s)
      Nakano K., Matsushita S., Yamaoka K., Saito K., Sasaguri Y., Yanagihara N., Tanaka S., Katsuki I, Tanaka Y
    • Journal Title

      J Immunology

      Volume: 186(6) Issue: 6 Pages: 3745-3752

    • DOI

      10.4049/jimmunol.1002475

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stimulation of IFN-gamma production by garlic lectin in mouse spleen cells : Involvement of IL-12 via activation of p38 MAPK and ERK in macrophages2011

    • Author(s)
      Dong Q., Sugiura T., Toyohira Y., Yoshida Y., Yanagihara N., Karasaki Y
    • Journal Title

      Phytomedicine

      Volume: 18 Pages: 309-316

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced spinal microglial activation and neuropathic pain after nerve injury in mice lacking three nitric oxide synthases2011

    • Author(s)
      Kuboyama K., Tsuda M., Tsutsui M., Toyohira Y., Saitoh-Tozaki H., Shimokawa H., Yanagihara N., Inoue K
    • Journal Title

      Mol Pain

      Volume: 7 Pages: 50-50

    • URL

      http://www.molecularpain.com/content/7/1/50

    • Related Report
      2013 Final Research Report
  • [Journal Article] Dendric cell-derived dopamine induceds IL-6-dependent Th17 polarization in rheumatoid arthritis2011

    • Author(s)
      Nakano K.,, et al.,
    • Journal Title

      J Immunology

      Volume: 186 Pages: 3745-3752

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Eeduced spinal microglial activation and neuropathic pain after nerve injury in mice lscking all three nitric oxide synthases2011

    • Author(s)
      K.Kuboyama, M.Tsuda, M.Tsutsui, Y.Toyohara, H.Tozaki-Saitoh, H.Shimokawa, N.Yanagihara, K.Inoue
    • Journal Title

      Mol Pain

      Volume: 7 : 50 Pages: 50-50

    • DOI

      10.1186/1744-8069-7-50

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Influence of work shift on glutamic acid and gamma-aminobutyric acid (GABA): Evaluation with proton magnetic resonance spectroscopy at 3T2011

    • Author(s)
      Kakeda S., et al.
    • Journal Title

      Psychiatric Research: Neuroimaging

      Volume: 192 Issue: 1 Pages: 55-59

    • DOI

      10.1016/j.pscychresns.2010.10.011

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] ノルアドレナリントランスポーターの赤ワインポリフェノールによる機能調節2014

    • Author(s)
      豊平由美子、小原剛、稲垣博英、高橋圭太、李暁佳、高橋浩二郎、柳原延章
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台国際センター、仙台
    • Year and Date
      2014-03-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 交感神経ー副腎髄質機能における免疫系及び植物性フラボノイドによる修飾2014

    • Author(s)
      柳原延章、豊平由美子、高橋圭太、稲垣博英、李暁佳、上野晋、筒井正人、高橋浩二郎
    • Organizer
      第87回日本薬理学会年会シンポジウム
    • Place of Presentation
      仙台国際センター、仙台
    • Year and Date
      2014-03-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 更年期障害患者における自律神経バランス変動の評価2014

    • Author(s)
      柳原延章、石明寛、中野正博、蜂須賀徹、後藤幸生
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台国際センター、仙台
    • Year and Date
      2014-03-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 選択的エストロゲン受容体調整薬タモキシフェン、ラロキシフェンのカテコールアミン生合成、分泌に及ぼす影響2014

    • Author(s)
      稲垣博英、豊平由美子、高橋圭太、上野晋、小原剛、筒井正人、高橋浩二郎、李暁佳、蜂須賀徹、柳原延章
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台国際センター、仙台
    • Year and Date
      2014-03-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 交感神経ー副腎髄質機能における免疫系及び植物性フラボノイドによる修飾2014

    • Author(s)
      柳原延章、豊平由美子、高橋圭太、稲垣博英、李暁佳、上野晋、筒井正人、高橋浩二郎
    • Organizer
      第87回日本薬理学会年会シンポジウム
    • Place of Presentation
      仙台国際センター、仙台
    • Related Report
      2013 Annual Research Report
  • [Presentation] 実験に有用な自然発症 急性心筋梗塞モデルの開発2014

    • Author(s)
      内田太郎、古野由美、谷本昭英、豊平由美子、喜名美香、久保田陽秋、坂梨まゆ子、松崎俊博、野口克彦、仲宗根淳子、大屋祐輔、柳原延章、下川宏明、田村雅仁、尾辻豊、筒井正人
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台国際センター、仙台
    • Related Report
      2013 Annual Research Report
  • [Presentation] 更年期障害患者における自律神経バランス変動の評価2014

    • Author(s)
      柳原延章、石 明寛、中野正博、蜂須賀 徹、後藤幸生
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台国際センター、仙台
    • Related Report
      2013 Annual Research Report
  • [Presentation] 選択的エストロゲン受容体調整薬タモキシフェン、ラロキシフェンのカテコールアミン生合成、分泌に及ぼす影響2014

    • Author(s)
      稲垣博英、豊平由美子、高橋圭太、上野 晋、小原 剛、筒井正人、高橋浩二郎、李暁佳、蜂須賀 徹、柳原延章
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台国際センター、仙台
    • Related Report
      2013 Annual Research Report
  • [Presentation] ノルアドレナリントランスポーターの赤ワインポリフェノールによる機能調節2014

    • Author(s)
      豊平由美子、小原 剛、稲垣博英、高橋圭太、李暁佳、高橋浩二郎、柳原延章
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台国際センター、仙台
    • Related Report
      2013 Annual Research Report
  • [Presentation] A novel vasculoprotective role of nitric oxide synthases in bone marrow-derived vascular progenitor cells2013

    • Author(s)
      Tsutsui M, Furuno Y, Morishita T, Yanagihara N, Tamura M, Shimokawa H, Otsuji Y
    • Organizer
      American Heart Association, Scientific Sessions
    • Place of Presentation
      Dallas Convention Center, Dallas, Texas USA
    • Year and Date
      2013-11-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Dual effects of nobiletin, a citrus polymethoxy flavones, on catecholamine signaling in cultured bovine adrenal medullary cells2013

    • Author(s)
      Zhang H. , Yanagihara N. , Toyohira Y., Takahashi K., Takahashi K
    • Organizer
      37th Congress of the International Union of Physiological Sciences
    • Place of Presentation
      International Convention Center, Birmingham, UK
    • Year and Date
      2013-07-24
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] ノルアドレナリントランスポーター機能に対するレスベラトロールの作用2013

    • Author(s)
      豊平由美子、小原剛、稲垣博英、高橋圭太、高橋浩二郎、柳原延章
    • Organizer
      第13回日本NO学会
    • Place of Presentation
      沖縄県医師会館、那覇
    • Year and Date
      2013-06-28
    • Related Report
      2013 Final Research Report
  • [Presentation]2013

    • Author(s)
      稲垣博英、豊平由美子、高橋圭太、高橋浩二郎、小原剛、上野晋、筒井正人、蜂須賀徹、柳原延章
    • Organizer
      第65回日本産婦人科学学術講演
    • Place of Presentation
      ロイトン札幌、札幌市
    • Year and Date
      2013-05-11
    • Related Report
      2013 Final Research Report
  • [Presentation] ウシ副腎髄質細胞の機能における選択的エストロゲン調整薬の影響について2013

    • Author(s)
      稲垣博英・豊平由美子・小原剛・蜂須賀徹・柳原延章
    • Organizer
      日本薬理学会年会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2013-03-23
    • Related Report
      2013 Final Research Report
  • [Presentation] Rhoキナーゼ阻害剤ファスジルによるノルエピネフリントランスポーター機能促進2013

    • Author(s)
      佐藤教昭、豊平由美子、高橋圭太、上野晋、筒井正人、柳原延章
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡国際会議場、福岡
    • Year and Date
      2013-03-23
    • Related Report
      2013 Final Research Report
  • [Presentation] Significance of the Nitric Oxide Synthase System in the Pathogenesis of the Cardiovascular System2013

    • Author(s)
      筒井正人、下川宏明、尾辻豊、柳原延章
    • Organizer
      第86回日本薬理学会年会シンポジウム
    • Place of Presentation
      福岡国際会議場、福岡
    • Year and Date
      2013-03-22
    • Related Report
      2013 Final Research Report
  • [Presentation] レスベラトロールはノルアドレナリントランスポーター機能を2相性に調節する2013

    • Author(s)
      豊平由美子、小原剛、稲垣博英、高橋圭太、高橋浩二郎、柳原延章
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡国際会議場、福岡
    • Year and Date
      2013-03-22
    • Related Report
      2013 Final Research Report
  • [Presentation] ペンタゾシンのモノアミントランスポータ活性に及ぼす影響2013

    • Author(s)
      小原剛, 豊平由美子・稲垣博英・高橋浩二郎・上野晋・佐多竹良・柳原延章
    • Place of Presentation
      福岡国際会議場、福岡
    • Year and Date
      2013-03-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Development of an experimentally useful animal model of spontaneous myocardial infarction2013

    • Author(s)
      Uchida T, Furuno Y, Tanimoto A, Toyohira Y, Sakanashi M, Matsuzaki T, Noguchi K, Nakasone J, Ohya Y, Yanagihara N, Shimokawa H, Tamura M, Otsuji Y, Tsutsui M
    • Organizer
      The 77th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Pacifico Yokohama, Yokohama
    • Year and Date
      2013-03-15
    • Related Report
      2013 Final Research Report
  • [Presentation] The effects of nicergoline, an ameliorator of cerebral circulation and metabolism, on the monoamine transporter2013

    • Author(s)
      Itoh H., Toyohira Y., Matsushima Y., Ueno S., Saeki S., Yanagihara N., Hachisuka K
    • Organizer
      43th Society for Neuroscience Annual Meeting
    • Place of Presentation
      San Diego Convention Center, San Diego
    • Related Report
      2013 Final Research Report
  • [Presentation] 骨髄由来血管前駆細胞に発現するNO合成酵素系のマウス血管病変形成に対する抑制作用2013

    • Author(s)
      古野由美、豊平由美子、上野晋、坂梨まゆ子、松﨑俊博、野口克彦、柳原延章、下川宏明、柳原延章、筒井正人、迎 寛
    • Organizer
      第13回日本NO学会
    • Place of Presentation
      沖縄県医師会館、那覇
    • Related Report
      2013 Annual Research Report
  • [Presentation] 気管支喘息におけるNOおよび各NOSアイソフォームの役割2013

    • Author(s)
      赤田憲太朗、矢寺和博、王克鏞、野口真吾、川波敏則、石本裕士、豊平由美子、下川宏明、柳原延章、筒井正人、迎 寛
    • Organizer
      第13回日本NO学会
    • Place of Presentation
      沖縄県医師会館、那覇
    • Related Report
      2013 Annual Research Report
  • [Presentation] NOS完全欠損マウスにおける神経行動につての検討(1):不安関連行動の発現とNOS系との関連性について2013

    • Author(s)
      上野 晋、筒井正人、豊平由美子、鍋島俊隆、下川宏明、柳原延章
    • Organizer
      第13回日本NO学会
    • Place of Presentation
      沖縄県医師会館、那覇
    • Related Report
      2013 Annual Research Report
  • [Presentation] NO合成酵素完全欠損マウスを用いたブレオマイシン肺線維化モデルにおけるNOの役割の検討2013

    • Author(s)
      野口真吾、矢寺和博、王克鏞、赤田憲太朗、山崎啓、川波敏則、石本裕士、豊平由美子、下川宏明、柳原延章、筒井正人、迎 寛
    • Organizer
      第13回日本NO学会
    • Place of Presentation
      沖縄県医師会館、那覇
    • Related Report
      2013 Annual Research Report
  • [Presentation] NOS完全欠損マウスにおける神経行動につての検討(2):抗うつ薬に対する反応性から検討したNOS系の役割について2013

    • Author(s)
      上野 晋、筒井正人、豊平由美子、鍋島俊隆、下川宏明、柳原延章
    • Organizer
      第13回日本NO学会
    • Place of Presentation
      沖縄県医師会館、那覇
    • Related Report
      2013 Annual Research Report
  • [Presentation] 循環器・腎臓病におけるNOSs系の病因的役割2013

    • Author(s)
      筒井正人、下川宏明、柳原延章、尾辻豊
    • Organizer
      第13回日本NO学会
    • Place of Presentation
      沖縄県医師会館、那覇
    • Related Report
      2013 Annual Research Report
  • [Presentation] 創薬に有用な自然発症 急性心筋梗塞モデルの開発2013

    • Author(s)
      内田太郎、古野由美、谷本昭英、豊平由美子、喜名美香、久保田陽秋、坂梨まゆ子、松崎俊博、野口克彦、仲宗根淳子、下川宏明、柳原延章、尾辻豊、田村雅仁、筒井正人
    • Organizer
      第66回日本薬理学会西南部会
    • Place of Presentation
      福岡大学薬学部、福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] 自律神経バランス測定による更年期障害の補助的診断法2013

    • Author(s)
      柳原延章
    • Organizer
      イノベーションジャパン2013―大学見本市
    • Place of Presentation
      東京ビックサイト、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] ウシ副腎髄質細胞におけるニコチン性アセチルコリン受容体を介したカテコールアミン生合成分泌に及ぼす選択的エストロゲン受容体調整薬の影響2013

    • Author(s)
      稲垣博英、豊平由美子、小原 剛、上野 晋、高橋圭太、高橋浩二郎、蜂須賀 徹、柳原延章
    • Organizer
      第31回産業医科大学学会総会
    • Place of Presentation
      産業医科大学、北九州
    • Related Report
      2013 Annual Research Report
  • [Presentation] The effects of nicergoline, an ameliorator of cerebral circulation and metabolism, on the monoamine transporter2013

    • Author(s)
      Itoh H., Toyohira Y., Matsushima Y., Ueno S., Saeki S., Yanagihara N., Hachisuka K
    • Organizer
      43th Society for Neuroscience Annual Meeting
    • Place of Presentation
      San Diego Convention Center, San Diego, CA, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 選択的エストロゲン受容体調整薬タモキシフェン、ラロキシフェンのカテコールアミン生合成、分泌に及ぼす影響2013

    • Author(s)
      稲垣博英、豊平由美子、高橋圭太、高橋浩二郎、小原 剛、上野 晋、筒井正人、蜂須賀 徹、柳原延章
    • Organizer
      第66回日本薬理学会西南部会
    • Place of Presentation
      福岡大学薬学部、福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] 更年期障害患者における自律神経バランス測定とその評価2013

    • Author(s)
      柳原延章、石 明寛、中野正博、蜂須賀 徹、後藤幸生
    • Organizer
      第66回日本薬理学会西南部会
    • Place of Presentation
      福岡大学薬学部、福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] A novel vasculoprotective role of nitric oxide synthases in bone marrow-derived vascular progenitor cells2013

    • Author(s)
      Tsutsui M, Furuno Y, Morishita T, Yanagihara N, Tamura M, Shimokawa H, Otsuji Y.
    • Organizer
      American Heart Association, Scientific Sessions
    • Place of Presentation
      Dallas Convention Center, Dallas, Texas, USA.
    • Related Report
      2013 Annual Research Report
  • [Presentation] 細菌リポ多糖体およびインターフェロン-beta刺激による一酸化窒素産生に及ぼす10-Hydroxy-trans-2-decenoic acid(ローヤルゼリー酸)の影響2013

    • Author(s)
      高橋圭太、杉山剛志、柳原 延章、森裕志
    • Organizer
      第86回 日本薬理学会年会
    • Place of Presentation
      福岡国際会議場、福岡、日本
    • Related Report
      2012 Research-status Report
  • [Presentation] レスベラトロールのノルアドレナリントランスポーター機能を二相性に調節する2013

    • Author(s)
      豊平 由美子、小原剛、稲垣博英、高橋圭太、高橋 浩二郎・柳原 延章
    • Organizer
      第86回 日本薬理学会年会
    • Place of Presentation
      福岡国際会議場、福岡、日本
    • Related Report
      2012 Research-status Report
  • [Presentation] Rhoキナーゼ阻害剤ファスジルによるノルエピネフリントランスポーター機能促進2013

    • Author(s)
      佐藤 教昭、豊平 由美子、高橋圭太、上野 晋、筒井正人、柳原 延章
    • Organizer
      第86回 日本薬理学会年会
    • Place of Presentation
      福岡国際会議場、福岡、日本
    • Related Report
      2012 Research-status Report
  • [Presentation] ウシ副腎髄質細胞の機能における選択的エストロゲン調整薬の影響について2013

    • Author(s)
      稲垣博英、豊平 由美子、小原剛、高橋圭太、蜂須賀 徹、柳原 延章
    • Organizer
      第85回 日本薬理学会年会
    • Place of Presentation
      福岡国際会議場、福岡、日本
    • Related Report
      2012 Research-status Report
  • [Presentation] 心血管系におけるNO合成酵素システムの意義2013

    • Author(s)
      筒井正人、下川宏明、尾辻豊、柳原 延章
    • Organizer
      第86回 日本薬理学会年会
    • Place of Presentation
      福岡国際会議場、福岡、日本
    • Related Report
      2012 Research-status Report
  • [Presentation] ペンタゾシンのモノアミントランスポーター活性に及ぼす影響2013

    • Author(s)
      小原剛、豊平由美子、稲垣博英、高橋圭太、上野晋、佐多竹良、柳原 延章
    • Organizer
      第86回 日本薬理学会年会
    • Place of Presentation
      福岡国際会議場、福岡、日本
    • Related Report
      2012 Research-status Report
  • [Presentation] The effects of nicergoline, an ameliorator of cerebral circulation and metabolism, on the monoamine Transporter2012

    • Author(s)
      Itoh H., Toyohira Y., Matsushima Y., Ueno S., Saeki S., Yanagihara N., Hachisuka K
    • Organizer
      8th WORLD STROKE CONGRESS
    • Place of Presentation
      Ulysses Guimarães Convention Center, Brasilia, Brazil
    • Year and Date
      2012-10-12
    • Related Report
      2013 Final Research Report
  • [Presentation] Plant flavonoids affecting adrenal medullary catecholamine biosynthesis and release2012

    • Author(s)
      Yanagihara N., Toyohira Y., Ueno S., Tsutsui M., Zhang H
    • Organizer
      10^<th> International Catecholamine symposium
    • Place of Presentation
      Asiloma Conference Granunds, Asiloma, CA, USA
    • Year and Date
      2012-09-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Novel vasculoprotective role of nitric oxide synthase (NOS) in Mice : Involvement of Bone-Marrow- Derived Vascular Progenitor Cells2012

    • Author(s)
      Furuno Y, Tsutsui M, Morishita T, Shimokawa H, Otsuji Y, Yanagihara N, Kabashima N, Serino R., Kanegae K, Miyamoto T, Nakamata J, Ishimatsu N, Tamura M
    • Organizer
      The 49th European Renal Association- European Dialysis and Transplant Association Congress
    • Place of Presentation
      Palais des Congres, Paris, France
    • Year and Date
      2012-05-24
    • Related Report
      2013 Final Research Report
  • [Presentation] Novel vasculoprotective role of nitric oxide synthases in bone-marrow-derived vascular progenitor cells2012

    • Author(s)
      Tsutsui M, Furuno Y, Morishita T, Yanagihara N, Tamura M, Shimokawa H, Otsuji Y
    • Organizer
      The 76th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Fukuoka Kokusai Center, Fukuoka, Japan
    • Year and Date
      2012-03-18
    • Related Report
      2013 Final Research Report
  • [Presentation] 赤ワイン含有のフラボノール類のカテコールアミン分泌に及ぼす影響2012

    • Author(s)
      坂巻路可・豊平由美子・外山健二・柳原延章
    • Organizer
      日本薬理学会年会
    • Place of Presentation
      京都国際会議場、京都
    • Year and Date
      2012-03-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 選択的エストロゲン受容体調整薬の副腎髄質細胞のカテコールアミン分泌に与える影響について2012

    • Author(s)
      稲垣博英・豊平由美子・小原剛・蜂須賀徹・柳原延章
    • Organizer
      日本薬理学会年会
    • Place of Presentation
      京都国際会議場、京都
    • Year and Date
      2012-03-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 植物フラボノイドのカテコールアミンシグナリングへの作用とその創薬的基盤研究2012

    • Author(s)
      柳原延章・豊平由美子・上野晋・筒井正人・張唅
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都国際会議場、京都 (シンポジウム)
    • Year and Date
      2012-03-15
    • Related Report
      2013 Final Research Report
  • [Presentation] 赤ワインポリフェノールのレスベラトロールがノルアドレナリントランスポーター機能に及ぼす影響2012

    • Author(s)
      豊平由美子・小原剛・稲垣博英・坂巻路可・高橋浩二郎・柳原延章
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都国際会議場、京都
    • Year and Date
      2012-03-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Plant flavonoids affecting adrenal medullary catecholamine biosynthesis and release2012

    • Author(s)
      Yanagihara N., Toyohira Y., Ueno S., Tsutsui M., Zhang H.
    • Organizer
      10th International Catecholamine Symposium
    • Place of Presentation
      Asiloma Conference Ground, Pacific Grove, CA, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] The effects of nicergoline, an ameliorator of cerebral circulation and metabolism, on the2012

    • Author(s)
      Itoh H., Toyohira Y., Matsushima Y., Ueno S., Saeki S., Yanagihara N., Hachisuka K.
    • Organizer
      8th WORLD STROKE CONGRESS
    • Place of Presentation
      Ulysses Guimares Convention Center, Brasilia, Brazil
    • Related Report
      2012 Research-status Report
  • [Presentation] Novel vasculoprotective role of nitric oxide synthase (NOS) in Mice: Involvement of2012

    • Author(s)
      Furuno Y, Tsutsui M, Morishita T, Shimokawa H, Otsuji Y, Yanagihara N, Kabashima N, Serino R, Kanegae K, Miyamoto T, Nakamata J, Ishimatsu N, Tamura M
    • Organizer
      The 49th European Renal Association-European Dialysis and Transplant Association
    • Place of Presentation
      Palais des Congres, Paris, France
    • Related Report
      2012 Research-status Report
  • [Presentation] 植物由来フラボノイドのカテコールアミンシグナリングへの薬理作用とその創薬的基盤研究2012

    • Author(s)
      柳原 延章 他
    • Organizer
      第85回 日本薬理学会年会シンポジウム
    • Place of Presentation
      国立京都国際会館、京都
    • Related Report
      2011 Research-status Report
  • [Presentation] 赤ワインポリフェノールのレスベラトロールがノルアドレナリントランスポーター機能に及ぼす影響2012

    • Author(s)
      豊平 由美子 他
    • Organizer
      第85回 日本薬理学会年会
    • Place of Presentation
      国立京都国際会館、京都
    • Related Report
      2011 Research-status Report
  • [Presentation] hoキナーゼ阻害剤ファスジルによるノルエピネフリントランスポーター機能のアップレギュレーション2012

    • Author(s)
      佐藤 教昭 他
    • Organizer
      第85回 日本薬理学会年会
    • Place of Presentation
      国立京都国際会館、京都
    • Related Report
      2011 Research-status Report
  • [Presentation] ペンタゾシンによるノルエピネフリントランスポーター抑制の機能解析2012

    • Author(s)
      小原 剛 他
    • Organizer
      第85回 日本薬理学会年会
    • Place of Presentation
      国立京都国際会館、京都
    • Related Report
      2011 Research-status Report
  • [Presentation] 選択的エストロゲン受容体調整薬のカテコールアミン分泌に与える影響2012

    • Author(s)
      稲垣博英 他
    • Organizer
      第85回 日本薬理学会年会
    • Place of Presentation
      国立京都国際会館、京都
    • Related Report
      2011 Research-status Report
  • [Presentation] 赤ワイン含有のフラボノール類のカテコールアミン分泌に及ぼす影響2012

    • Author(s)
      坂巻 路可 他
    • Organizer
      第85回 日本薬理学会年会
    • Place of Presentation
      国立京都国際会館、京都
    • Related Report
      2011 Research-status Report
  • [Presentation] Ca^<2+>-dependent effects of nobiletin, a citrus flavonoid, on catecholamine synthesis and secretion in cultured bovine adrenal medullary cells2011

    • Author(s)
      Yanagihara N., Zhang H., Toyohira Y., Ueno S., Tsutsui M., Takahashi K
    • Organizer
      7^<th> International Forum on the Development of Traditional Chinese Medicine
    • Place of Presentation
      Tianjin, China
    • Year and Date
      2011-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Complete Disruption of All Nitric Oxide Synthase Genes Causes Markedly Accelerated Renal Lesion Formation in Mice in vivo2011

    • Author(s)
      Morisada N, Iijima K, Matsuo M, Shimokawa H, Yanagihara N, Tsutsui M
    • Organizer
      The 75th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Pacifico Yokohama, Yokohama, Japan
    • Year and Date
      2011-08-03
    • Related Report
      2013 Final Research Report
  • [Presentation] Accelerated Vascular Lesion Formation in Mice Lacking All Nitric Oxide Synthases : Contribution of Bone Marrow Cells2011

    • Author(s)
      Furuno Y, Morishita T, Yanagihara N, Shimokawa H, Otsuji Y, Tamura M, Tsutsui M
    • Organizer
      The 75th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Pacifico Yokohama, Yokohama, Japan
    • Year and Date
      2011-08-03
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of flavonoids on catecholamine synthesis and secretion in cultured bovine adrenal medullary cells2011

    • Author(s)
      Yanagihara N., Zhang H., Toyohira Y., Ueno S., Tsutsui M., Takahashi K
    • Organizer
      The 8th IBRO World Congress of Neuroscience
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2011-07-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of flavonoids on catecholamine synthesis and secretion in cultured bovine adrenal medullary cells2011

    • Author(s)
      Yanagihara N., et al.,
    • Organizer
      The 8th IBRO World Congress of Neuroscience
    • Place of Presentation
      Fortezza da Basso, Florence, Italy
    • Related Report
      2011 Research-status Report
  • [Presentation] Ca2+-dependent effects of nobiletin, a citrus flavonoid, on catecholamine synthesis and secretion in cultured bovine adrenal2011

    • Author(s)
      Yanagihara N., et al.,
    • Organizer
      7th International Forum on the Development of Traditional Chinese Medicine(招待講演)
    • Place of Presentation
      Tianjin Saixiang Convention Center, Tianjin, China
    • Related Report
      2011 Research-status Report
  • [Presentation] Accelerated Vascular Lesion Formation in Mice Lacking All Nitric Oxide Synthases: Contribution of Bone Marrow Cells2011

    • Author(s)
      Furuno Y., et al.,
    • Organizer
      The 75th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] Complete Disruption of All Nitric Oxide Synthase Genes Causes Markedly Accelerated Renal Lesion Formation in Mice in Vivo2011

    • Author(s)
      Morisada N., et al.,
    • Organizer
      The 75th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2011 Research-status Report
  • [Book] SOYBEANS and HEALTH2011

    • Author(s)
      Yanagihara N., et al.
    • Publisher
      INTECH
    • Related Report
      2011 Research-status Report
  • [Book] Insight into the pharmacological effects of soy isoflavones on catecholamine system. In Soybean and Health (edited by El-Shemy H.)

    • Author(s)
      Yanagihara N. Toyohira Y., Liu M., Ueno S., Tsutsui M., Zhang H
    • Publisher
      INTECH, Croatia
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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