| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Results of this study using trans-chromosomic mice containing a human CYP3A gene cluster suggested that expression of CYP3A4 in liver shows sex differences and is positively regulated by estradiol. However, it is unlikely that estradiol directly regulates the CYP3A4 expression via estrogen receptor alpha. In addition, it was suggested that there are sex differences in induction of CYP3A4 expression in liver. Interestingly, no sex difference was observed in the intestinal expression and induction of CYP3A4. These findings demonstrated that sex differences in the hepatic expression of CYP3A4 are observed in trans-chromosomic mice containing a human CYP3A gene cluster, although it is hard to analyze the sex differences in human.
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