The pharmaco-epidemiological study about serious and opportunistic infections under treatment of the biologics and the molecular target medicine.

• Project/Area Number: 23590171
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: TANAKA Michi 東京医科歯科大学, 医学部, 非常勤講師 (50277141)
• Co-Investigator(Kenkyū-buntansha): NANNKI Toshihiro 帝京大学, 医学部, 准教授 (00282749) ; KOIKE Ryuji 東京医科歯科大学, 医学部附属病院, 准教授 (50250220) ; HARIGAI Masayoshi 東京医科歯科大学, 医学部, 教授 (20238207) ; MIYASAKA Nobuyuki 東京医科歯科大学, 医学部, 非常勤講師 (30157622)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: リウマチ性疾患 / 関節リウマチ / 免疫抑制療法 / 生物学的製剤 / 肺感染症 / 日和見感染症 / 膠原病 / 分子標的薬 / 重篤肺感染症 / 日和見肺感染症 / 薬剤疫学研究

Research Abstract

Prospective cohort study to identify risk factors for development of pulmonary infection in patients receiving immunosuppressive treatment for rheumatic diseases.: 766 patients with rheumatic disease enrolled. Older age, higher Brinkman index, higher serum Cr level, and disturbed performance status were significantly associated with development of pulmonary infection.
Pneumocystis jirovecii pneumonia (PCP) in patients with rheumatoid arthritis receiving adalimumab: a retrospective review and case-control study of 17 patients.: Data from 17 RA patients who were diagnosed with PCP and from 89 RA patients who did not develop PCP during adalimumab treatment were collected. The patients with PCP were significantly older and had more structural changes than the patients without PCP.

Research Products

• [Journal Article] Clinical characteristics and risk factors for Pneumocystis jirovecii pneumonia in patients with rheumatoid arthritis receiving adalimumab : a retrospective review and case-control study of 17 patients (2013)
  • Author(s): Watanabe K, Sakai R, Koike R, Sakai F, Sugiyama H, Tanaka M, Komano Y, Akiyama Y, Mimura T, Kaneko M, Tokuda H, Iso T, Motegi M, Ikeda K, Nakajima H, Taki H, Kubota T, Kodama H, Sugii S, Kuroiwa T, Nawata Y, Shiozawa K, Ogata A, Sawada S, Matsukawa Y, Okazaki T, Mukai M, Iwahashi M, Saito K, Tanaka Y, Nanki T, Miyasaka N, Harigai M
  • Journal Title: Mod Rheumatol Volume: 23(6) Pages: 1085-93
  • Peer Reviewed
• [Journal Article] Clinical characteristics and risk factors for Pneumocystis jirovecii pneumonia in patients with rheumatoid arthritis receiving adalimumab: a retrospective review and case-control study of 17 patients. (2012)
  • Author(s): Watanabe K, Sakai R, Koike R, Sakai F, Sugiyama H, Tanaka M, et al.
  • Journal Title: Mod Rheumatol.
  • DOI: 10.1007/s10165-012-0796-5
• [Presentation] 膠原病における免疫抑制療法下の肺感染症に関する前向き研究 (2013)
  • Author(s): 山崎隼人
  • Organizer: リウマチヤングアカデミー
  • Year and Date: 2013-07-13
• [Presentation] 膠原病における免疫抑制療法下の肺感染症に関する前向き研究 (2013)
  • Author(s): 山崎隼人
  • Organizer: 第57回日本リウマチ学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] 膠原病における免疫抑制療法下の肺感染症に関する前向き研究 (2013)
  • Author(s): 山崎隼人、酒井良子、小池竜司、田中みち、南木敏宏、渡部香織、宮坂信之、針谷正祥
  • Organizer: 第57回日本リウマチ学会総会・学術集会
  • Place of Presentation: 京都（国立京都国際会館）
• [Presentation] How to assess risks for pulmonary infections in patients receiving immunosuppressive treatment for rheumatic disease? A report from a large scale prospective cohort study (2012)
  • Author(s): 山崎隼人
  • Organizer: American college of Rheumatology
  • Place of Presentation: ワシントン
• [Presentation] TNF阻害薬使用関節リウマチ患者におけるニューモシスチス肺炎 (2012)
  • Author(s): 渡部香織
  • Organizer: 第56回日本リウマチ学会総会・学術集会
  • Place of Presentation: 東京
• [Presentation] How to Assess Risks for Pulmonary Infection in Patients Receiving Immunosuppressive Treatment for Rheumatic Diseases? A Report From a Large-Scale Prospective Cohort Study (2012)
  • Author(s): Hayato Yamazaki et al.
  • Organizer: AMERICAN COLLEGE OF RHEUMATOLOGY (ＡＣＲ)2012
  • Place of Presentation: Ｗａｓｈｉｎｇｔｏｎ ＤＣ
• [Presentation] アダリムマブ使用関節リウマチ患者におけるニューモシスチス肺炎 (2011)
  • Author(s): 渡部香織
  • Organizer: 第39回日本臨床免疫学会
  • Place of Presentation: 東京
• [Presentation] Clinical characteristics of and risk factors for PCP in patients with rheumatoid arthritis receiving TNF antagonists (2011)
  • Author(s): 針谷正祥
  • Organizer: The European League Against Rheumatism
  • Place of Presentation: ロンドン
• [Presentation] CLINICAL CHARACTERISTICS OF AND RISK FACTORS FOR Pneumocystis jirovecii PNEUMONIA IN PATIENTS WITH RHEUMATOID ARTHRITIS RECEIVING TNF ANTAGONISTS. (2011)
  • Author(s): M. Harigai.
  • Organizer: The European League Against Rheumatism (EULAR)2011
  • Place of Presentation: ロンドン
• [Presentation] アダリムマブ使用関節リウマチ患者におけるニューモシスチス肺炎 (2011)
  • Author(s): 渡部香織、小池竜司、酒井良子、田中みち、山崎隼人、駒野有希子、南木敏宏、宮坂信之、針谷正祥
  • Organizer: 第39回日本臨床免疫学会
  • Place of Presentation: 東京都
• [Presentation] 膠原病における免疫抑制療法下の肺感染症に関する研究
  • Author(s): 山崎隼人、酒井良子、小池竜司、田中みち、南木敏宏、渡部香織、宮坂信之、針谷正祥
  • Organizer: リウマチヤングアカデミー
  • Place of Presentation: 北広島クラッセホテル