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Regional Difference in the Effect of Influx/Efflux Transporters and Metabolic Enzymes on Intestinal Drug Absorption

Research Project

Project/Area Number 23590175
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical pharmacy
Research InstitutionKanazawa University

Principal Investigator

SHIRASAKA Yoshiyuki  金沢大学, 薬学系, 助教 (60453833)

Co-Investigator(Kenkyū-buntansha) IKUMI Tamai  金沢大学, 薬学系, 教授 (20155237)
TAKEO Nakanishi  金沢大学, 薬学系, 准教授 (30541742)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords薬学 / 薬物動態学 / 経口吸収 / 徐放性製剤 / トランスポーター / 代謝酵素 / 薬物間相互作用 / 生体分子
Research Abstract

In the present study, we aimed to clarify the site-specific contribution of transporters and metabolic enzymes to the intestinal drug absorption. The rat in situ studies with talinolol and colchicine demonstrated site-specific drug absorption presumably due to differential expression and function of OATP and P-gp. Further analysis revealed presence of multiple binding sites on OATP2B1 with different affinity for drugs. Meanwhile, microsomal studies demonstrated that CYP3A5 genotype and expression level have a significant impact on inhibitory potency for CYP3A-catalyzed drug metabolism, but that the magnitude of its effect is inhibitor-substrate pair specific. The results of the study focusing on CYP2C19 show that, although metabolites contribute to in vivo DDIs, their relative abundance in circulation does not predict their contribution to in vivo DDI risk. These findings revealed involvement of influx/efflux transporters and metabolic enzymes in the intestinal drug absorption process.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (49 results)

All 2014 2013 2012 2011 Other

All Journal Article (20 results) (of which Peer Reviewed: 20 results) Presentation (29 results) (of which Invited: 1 results)

  • [Journal Article] Substrate- and dose-dependent drug interactions with grapefruit juice caused by multiple binding sites on OATP2B12014

    • Author(s)
      Shirasaka Y, Mori T, Murata Y, Nakanishi T, and Tamai I
    • Journal Title

      Pharm Res

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Substrate- and dose-dependent drug interactions with grapefruit juice caused by multiple binding sites on OATP2B1.2014

    • Author(s)
      Shirasaka Y, Mori T, Murata Y, Nakanishi T, and Tamai I.
    • Journal Title

      Pharm Res.

      Volume: In Press Issue: 8 Pages: 2035-2043

    • DOI

      10.1007/s11095-014-1305-7

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MDR1 is related to intestinal epithelial injury induced by acetylsalicylic acid2013

    • Author(s)
      Kugai M, Uchiyama K, Tsuji T, Yoriki H, Fukui A, Qin Y, Higashimura Y, Mizushima K, Yoshida N, Katada K, Kamada K, Handa O, Takagi T, Konishi H, Yagi N, Yoshikawa T, Shirasaka Y, Tamai I, Naito Y, and Itoh Y
    • Journal Title

      Cell Physiol Biochem

      Volume: 32(4) Pages: 942-950

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Major active components in grapefruit, orange and apple juices responsible for OATP2B1-mediated drug interactions2013

    • Author(s)
      Shirasaka Y, Shichiri M, Mori T, Nakanishi T, and Tamai I
    • Journal Title

      J Pharm Sci

      Volume: 102(9) Pages: 3418-3426

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rodrigues AD. Effect of CYP3A5 expression on the inhibition of CYP3A-catalyzed drug metabolism : impact on modeling CYP3A-mediated drug-drug interactions2013

    • Author(s)
      Shirasaka Y, Chang SY, Grubb MF, Peng CC, Thummel KE, Isoherranen N
    • Journal Title

      Drug Metab Dispos

      Volume: 41(8) Pages: 1566-1574

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of CYP2C19 and CYP3A4 by omeprazole metabolites and their contribution to drug-drug interactions2013

    • Author(s)
      Shirasaka Y, Sager JE, Lutz JD, Davis C, and Isoherranen N
    • Journal Title

      Drug Metab Dispos

      Volume: 41(7) Pages: 1414-1424

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-lasting inhibitory effect of apple and orange juices, but not grapefruit juice, on OATP2B1- mediated drug absorption2013

    • Author(s)
      Shirasaka Y, Shichiri M, Murata Y, Mori T, Nakanishi T, and Tamai I
    • Journal Title

      Drug Metab Dispos

      Volume: 41(3) Pages: 615-621

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] MDR1 is related to intestinal epithelial injury induced by acetylsalicylic acid.2013

    • Author(s)
      Kugai M, Uchiyama K, Tsuji T, Yoriki H, Fukui A, Qin Y, Higashimura Y, Mizushima K, Yoshida N, Katada K, Kamada K, Handa O, Takagi T, Konishi H, Yagi N, Yoshikawa T, Shirasaka Y, Tamai I, Naito Y, and Itoh Y.
    • Journal Title

      Cell Physiol Biochem.

      Volume: 32 Issue: 4 Pages: 942-950

    • DOI

      10.1159/000354497

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Major active components in grapefruit, orange and apple juices responsible for OATP2B1-mediated drug interactions.2013

    • Author(s)
      Shirasaka Y, Shichiri M, Mori T, Nakanishi T, and Tamai I.
    • Journal Title

      J Pharm Sci.

      Volume: 102 Issue: 9 Pages: 3418-3426

    • DOI

      10.1002/jps.23653

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of CYP3A5 expression on the inhibition of CYP3A-catalyzed drug metabolism: impact on modeling CYP3A-mediated drug-drug interactions.2013

    • Author(s)
      Shirasaka Y, Chang SY, Grubb MF, Peng CC, Thummel KE, Isoherranen N, Rodrigues AD.
    • Journal Title

      Drug Metab Dispos.

      Volume: 41 Issue: 8 Pages: 1566-1574

    • DOI

      10.1124/dmd.112.049940

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of CYP2C19 and CYP3A4 by omeprazole metabolites and their contribution to drug-drug interactions.2013

    • Author(s)
      Shirasaka Y, Sager JE, Lutz JD, Davis C, and Isoherranen N.
    • Journal Title

      Drug Metab Dispos.

      Volume: 41 Issue: 7 Pages: 1414-1424

    • DOI

      10.1124/dmd.113.051722

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-lasting inhibitory effect of apple and orange juices, but not grapefruit juice, on OATP2B1-mediated drug absorption.2013

    • Author(s)
      Shirasaka Y., Shichiri M, and Tamai I.
    • Journal Title

      Drug Metab Dispos.

      Volume: 41 Issue: 3 Pages: 615-621

    • DOI

      10.1124/dmd.112.049635

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Major active components in grapefruit, orange and apple juices responsible for OATP2B1-mediated drug interactions.2013

    • Author(s)
      Shirasaka Y., Shichiri M, Nakanishi T., and Tamai I.
    • Journal Title

      J Pharm Sci.

      Volume: 102 Issue: 1 Pages: 280-288

    • DOI

      10.1002/jps.23357

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Active intestinal absorption of fluoroquinolone antibacterial agent ciprofloxacin by organic anion transporting polypeptide, Oatp1a52012

    • Author(s)
      Arakawa H, Shirasaka Y, Haga M, Nakanishi T, and Tamai I
    • Journal Title

      Biopharm Drug Dispos

      Volume: 33(6) Pages: 332-341

    • NAID

      120004997009

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of Functional Groups on the Surface of Carboxyl Group-Terminated Polyamidoamine Dendrimers Bearing Arbutin in Inhibition of Na(+)/Glucose Cotransporter 1 (SGLT1)-Mediated d-Glucose Uptake2012

    • Author(s)
      Sakuma S, Kanamitsu S, Teraoka Y, Masaoka Y, Kataoka M, Yamashita S, Shirasaka Y, Tamai I, Muraoka M, Nakatsuji Y, Kida T, and Akashi M
    • Journal Title

      Mol Pharm

      Volume: 9(4) Pages: 922-929

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional pleiotropy of organic anion transporting polypeptide OATP2B1 due to multiple binding sites2012

    • Author(s)
      Shirasaka Y, Mori T, Shichiri M, Nakanishi T, and Tamai I
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: 27(3) Pages: 360-364

    • NAID

      130004463259

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Active intestinal absorption of fluoroquinolone antibacterial agent ciprofloxacin by organic anion transporting polypeptide.2012

    • Author(s)
      Arakawa H., Shirasaka Y., Haga M., Nakanishi T., and Tamai I.
    • Journal Title

      Biopharm Drug Dispos.

      Volume: 33 Issue: 6 Pages: 332-341

    • DOI

      10.1002/bdd.1809

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Functional pleiotropy of organic anion transporting polypeptide OATP2B1 due to multiple binding sites.2012

    • Author(s)
      Shirasaka Y., Mori T., Shichiri M., Nakanishi T., and Tamai I.
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: In press

    • NAID

      130004463259

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Involvement of Functional Groups on the Surface of Carboxyl Group-Terminated Polyamidoamine Dendrimers Bearing Arbutin in Inhibition of Na(+)/Glucose Cotransporter 1 (SGLT1)-Mediated d-Glucose Uptake.2012

    • Author(s)
      Sakuma S., Kanamitsu S., Teraoka Y., Masaoka Y., Kataoka M., Yamashita S., Shirasaka Y., Tamai I., Muraoka M., Nakatsuji Y., Kida T., and Akashi M.
    • Journal Title

      Mol Pharm.

      Volume: 9 Pages: 922-929

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differential effect of grapefruit juice on intestinal absorption of statins due to inhibition of organic anion transporting polypeptide and/or P-glycoprotein.2011

    • Author(s)
      Shirasaka Y., Suzuki K., Nakanishi T., and Tamai I.
    • Journal Title

      J Pharm Sci

      Volume: 100 Issue: 9 Pages: 3843-3853

    • DOI

      10.1002/jps.22586

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Inhibition of CYP2C19 and CYP3A4 by Omeprazole and its Metabolites2013

    • Author(s)
      Jennifer E. Sager, Yoshiyuki Shirasaka, Justin D. Lutz, Connie Davis, and Nina Isoherranen
    • Organizer
      18th International Conference on Cytochrome P450
    • Place of Presentation
      Husky Union Building (HUB), University of Washington, Seattle, WA
    • Year and Date
      2013-06-19
    • Related Report
      2013 Final Research Report
  • [Presentation] Impact of CYP3A5 Expression on CYP3A-Mediated Drug-Drug Interactions–Based on Research Abroad for Improving English, Experiencing Other Cultures, Meeting New People, Challenging Myself, and Becoming Global Expert in Pharmaceutics-2013

    • Author(s)
      Yoshiyuki Shirasaka
    • Organizer
      日本薬剤学会第28年会東西合同グローバルGEセミナーワークショップ.
    • Place of Presentation
      ウインクあいち(愛知県産業労働センター)/名古屋
    • Year and Date
      2013-05-25
    • Related Report
      2013 Final Research Report
  • [Presentation] Inhibition of CYP2C19 and CYP3A4 by Omeprazole Metabolites and Their Contribution to Drug-Drug Interactions2013

    • Author(s)
      Yoshiyuki Shirasaka, Jennifer Sager, Justin Lutz, Connie Davis, and Nina Isoherranen
    • Organizer
      日本薬剤学会第28年会
    • Place of Presentation
      ウインクあいち(愛知県産業労働センター)/名古屋
    • Year and Date
      2013-05-25
    • Related Report
      2013 Final Research Report
  • [Presentation] Interindividual Variability of CYP2C19-Catalyzed Drug Metabolism Due to Differences in the Diplotypes2013

    • Author(s)
      Yoshiyuki Shirasaka, Amarjit S. Chaudhry, Timothy Wong, Justina C. Calamia, Nina Isoherranen, Allan E. Rettie, Erin G. Schuetz, and Kenneth E. Thummel
    • Organizer
      10th International ISSX Meeting
    • Place of Presentation
      The Westin Harbour Castle, Toronto, Ontario, Canada
    • Related Report
      2013 Final Research Report
  • [Presentation] Interindividual Variability of CYP2C19-Catalyzed Drug Metabolism Due to Differences in the Diplotypes2013

    • Author(s)
      Yoshiyuki Shirasaka, Amarjit S. Chaudhry, Timothy Wong, Justina C. Calamia, Nina Isoherranen, Allan E. Rettie, Erin G. Schuetz, and Kenneth E. Thummel.
    • Organizer
      10th International ISSX Meeting
    • Place of Presentation
      The Westin Harbour Castle (Toronto, Canada)
    • Related Report
      2013 Annual Research Report
  • [Presentation] A Role of Prostaglandin Transporter in Regulating PGE2 Release from Human Bronchial BEAS-2B Cells under Inflammatory Conditions2012

    • Author(s)
      Yoshiyuki Shirasaka, Takeo Nakanishi, Taku Kasai, Megumi Scichiri, Kazuyuki Hayashi, Akio Nishiura, and Ikumi Tamai
    • Organizer
      第26回日本薬物動態学会年会
    • Place of Presentation
      タワーホール船橋/千葉
    • Year and Date
      2012-11-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Substrate-Dependent Drug-Grapefruit Juice Interactions Caused by Multiple Binding Sites on OATP2B12012

    • Author(s)
      Takanori Mori, Yoshiyuki Shirasaka, Yukiko Murata, Takeo Nakanishi and Ikumi Tamai
    • Organizer
      第26回日本薬物動態学会年会
    • Place of Presentation
      タワーホール船橋/千葉
    • Year and Date
      2012-11-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Long-Lasting Effect of Fruit Juice on Intestinal Absorptive Transporter OATP2B12012

    • Author(s)
      Yukiko Murata, Megumi Shichiri, Takanori Mori, Yoshiyuki Shirasaka, Takeo Nakanishi and Ikumi Tamai
    • Organizer
      第26回日本薬物動態学会年会
    • Place of Presentation
      タワーホール船橋/千葉
    • Year and Date
      2012-11-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Impact of CYP3A5 Expression on the Inhibition of CYP3A-Catalyzed Drug Metabolism : Considerations for Modeling CYP3A-Mediated Drug-Drug Interactions2012

    • Author(s)
      Yoshiyuki Shirasaka, Chi-Chi Peng, Shu-Ying Chang, Mary F. Grubb, Stephen R. Johnson, A. David Rodrigues, Kenneth E. Thummel, and Nina Isoherranen
    • Organizer
      18th North American Regional ISSX Meeting
    • Place of Presentation
      Hilton Anatole Dallas Hotel, Dallas, Texas, USA
    • Year and Date
      2012-10-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Functional Pleiotropy of OATP2B1 Due to Multiple Binding Sites2011

    • Author(s)
      Yoshiyuki Shirasaka, Takanori Mori, Megumi Shichiri, Satoshi Koyama, Yukiko Murata, Yusuke Hoshino, Takeo Nakanishi, and Ikumi Tamai
    • Organizer
      第26回日本薬物動態学会年会
    • Place of Presentation
      広島国際会議場/広島
    • Year and Date
      2011-11-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Drug Absorption and Interaction on Intestinal Transporters2011

    • Author(s)
      Ikumi Tamai, Yoshiyuki Shirasaka, and Takeo Nakanishi
    • Organizer
      第26回日本薬物動態学会年会
    • Place of Presentation
      広島国際会議場/広島
    • Year and Date
      2011-11-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Variability of Fruit Juice-Drug Interaction in Absorption Process Caused by Multiple Binding Sites on OATP2B12011

    • Author(s)
      Takanori Mori, Yoshiyuki Shirasaka, Megumi Shichiri, Satoshi Koyama, Yukiko Murata, Yusuke Hoshino, Takeo Nakanishi, and Ikumi Tamai
    • Organizer
      第26回日本薬物動態学会年会
    • Place of Presentation
      広島国際会議場/広島
    • Year and Date
      2011-11-16
    • Related Report
      2013 Final Research Report
  • [Presentation] OATP/P-gp基質薬物の消化管吸収動態解析に基づく徐放性製剤設計の最適化2011

    • Author(s)
      白坂善之
    • Organizer
      日本薬剤学会経口吸収フォーカスグループ第2回合宿討論会
    • Place of Presentation
      KKR京都「くに荘」/京都
    • Year and Date
      2011-09-05
    • Related Report
      2013 Final Research Report
  • [Presentation] Attenuation of Oral Absorption of P-glycoprotein Substrate Drugs by Administrating in Controlled-Release Formulation2011

    • Author(s)
      Yoshiyuki Shirasaka, Takeo Nakanishi, Peter Langguth, and Ikumi Tamai
    • Organizer
      International Symposium on BA/BE of Oral Drug Products
    • Place of Presentation
      Kobe International Conference Center/Kobe, Japan
    • Year and Date
      2011-06-30
    • Related Report
      2013 Final Research Report
  • [Presentation] P-gpを介した薬物吸収動態解析に基づいた徐放性製剤設計の最適化2011

    • Author(s)
      白坂善之、Peter Langguth、中西猛夫、玉井郁巳
    • Organizer
      日本薬剤学会第26年会
    • Place of Presentation
      タワーホール船堀/東京
    • Year and Date
      2011-05-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Differential Interaction of Fruit Juices with Transporter-Mediated Absorption of Drugs2011

    • Author(s)
      Megumi Shichiri, Yoshiyuki Shirasaka, Takanori Mori, Takeo Nakanishi, and Ikumi Tamai
    • Organizer
      The 4th Asian Pacific ISSX Regional Meeting
    • Place of Presentation
      Tainan, Taiwan
    • Year and Date
      2011-04-24
    • Related Report
      2013 Final Research Report
  • [Presentation] P-gpを介した薬物吸収動態解析に基づいた徐放性製剤設計の最適化2011

    • Author(s)
      白坂善之、Peter Langguth、中西猛夫、玉井郁巳
    • Organizer
      日本薬剤学会第26年会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] OATP/P-gp 基質薬物の消化管吸収動態解析に基づく徐放性製剤設計の最適化2011

    • Author(s)
      白坂善之
    • Organizer
      第2回 経口吸収FG合宿検討会
    • Place of Presentation
      KKR京都「くに荘」(京都府)
    • Related Report
      2011 Research-status Report
  • [Presentation] Attenuation of Oral Absorption of P-glycoprotein Substrate Drugs by Administrating in Controlled-Release Formulation2011

    • Author(s)
      Yoshiyuki Shirasaka, Takeo Nakanishi, Peter Langguth, and Ikumi Tamai
    • Organizer
      International Symposium on BA/BE of Oral Drug Products
    • Place of Presentation
      Kobe International Conference Center(兵庫県)
    • Related Report
      2011 Research-status Report
  • [Presentation] FUNCTIONAL PLEIOTROPY OF OATP2B1 DUE TO MULTIPLE BINDING SITES2011

    • Author(s)
      Yoshiyuki Shirasaka, Takanori Mori, Megumi Shichiri, Satoshi Koyama, Yukiko Murata, Yusuke Hoshino, Takeo Nakanishi and Ikumi Tamai
    • Organizer
      第26回日本薬物動態学会
    • Place of Presentation
      広島国際会議場(広島県)
    • Related Report
      2011 Research-status Report
  • [Presentation] VARIABILITY OF FRUIT JUICE-DRUG INTERACTION IN ABSORPTION PROCESS CAUSED BY MULTIPLE BINDING SITES ON OATP2B12011

    • Author(s)
      Takanori Mori, Yoshiyuki Shirasaka, Megumi Shichiri, Satoshi Koyama, Yukiko Murata, Yusuke Hoshino, Takeo Nakanishi and Ikumi Tamai
    • Organizer
      第26回日本薬物動態学会
    • Place of Presentation
      広島国際会議場(広島県)
    • Related Report
      2011 Research-status Report
  • [Presentation] DRUG ABSORPTION AND INTERACTION ON INTESTINAL TRANSPORTERS2011

    • Author(s)
      Ikumi Tamai, Yoshiyuki Shirasaka, Takeo Nakanishi
    • Organizer
      第26回日本薬物動態学会
    • Place of Presentation
      広島国際会議場(広島県)
    • Related Report
      2011 Research-status Report
  • [Presentation] Inhibition of CYP2C19 and CYP3A4 by Omeprazole and its Metabolites

    • Author(s)
      Jennifer E. Sager, Yoshiyuki Shirasaka, Justin D. Lutz, Connie Davis, and Nina Isoherranen.
    • Organizer
      18th International Conference on Cytochrome P450
    • Place of Presentation
      Husky Union Building (HUB), University of Washington (Seattle, USA)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Impact of CYP3A5 Expression on CYP3A-Mediated Drug-Drug Interactions –Based on Research Abroad for Improving English, Experiencing Other Cultures, Meeting New People, Challenging Myself, and Becoming Global Expert in Pharmaceutics-

    • Author(s)
      Yoshiyuki Shirasaka
    • Organizer
      日本薬剤学会第28年会
    • Place of Presentation
      ウインクあいち/愛知県産業労働センター (名古屋)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Inhibition of CYP2C19 and CYP3A4 by Omeprazole Metabolites and Their Contribution to Drug-Drug Interactions

    • Author(s)
      Yoshiyuki Shirasaka, Jennifer Sager, Justin Lutz, Connie Davis, and Nina Isoherranen.
    • Organizer
      日本薬剤学会第28年会
    • Place of Presentation
      ウインクあいち/愛知県産業労働センター (名古屋)
    • Related Report
      2013 Annual Research Report
  • [Presentation] A Role of Prostaglandin Transporter in Regulating PGE2 Release from Human Bronchial BEAS-2B Cells under Inflammatory Conditions

    • Author(s)
      Yoshiyuki Shirasaka, Takeo Nakanishi, Taku Kasai, Megumi Scichiri, Kazuyuki Hayashi, Akio Nishiura, and Ikumi Tamai.
    • Organizer
      第26回日本薬物動態学会年会
    • Place of Presentation
      タワーホール船橋 (東京都)
    • Related Report
      2012 Research-status Report
  • [Presentation] Substrate-Dependent Drug-Grapefruit Juice Interactions Caused by Multiple Binding Sites on OATP2B1

    • Author(s)
      Takanori Mori, Yoshiyuki Shirasaka, Yukiko Murata, Takeo Nakanishi and Ikumi Tamai.
    • Organizer
      第26回日本薬物動態学会年会
    • Place of Presentation
      タワーホール船橋 (東京都)
    • Related Report
      2012 Research-status Report
  • [Presentation] Long-Lasting Effect of Fruit Juice on Intestinal Absorptive Transporter OATP2B1

    • Author(s)
      Yukiko Murata, Megumi Shichiri, Takanori Mori, Yoshiyuki Shirasaka, Takeo Nakanishi and Ikumi Tamai.
    • Organizer
      第26回日本薬物動態学会年会
    • Place of Presentation
      タワーホール船橋 (東京都)
    • Related Report
      2012 Research-status Report
  • [Presentation] Impact of CYP3A5 Expression on the Inhibition of CYP3A-Catalyzed Drug Metabolism: Considerations for Modeling CYP3A-Mediated Drug-Drug Interactions

    • Author(s)
      Yoshiyuki Shirasaka, Chi-Chi Peng, Shu-Ying Chang, Mary F. Grubb, Stephen R. Johnson, A. David Rodrigues, Kenneth E. Thummel, and Nina Isoherranen.
    • Organizer
      18th North American Regional ISSX Meeting
    • Place of Presentation
      Hilton Anatole Dallas Hotel (USA)
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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