| Project/Area Number |
23590178
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Tokyo University of Science (2012-2013)
University of Yamanashi (2011) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OGUCHI Toshio 山梨大学, 医学部附属病院, 教授 (30169255)
IIJIMA Tetsuya 山梨大学, 医学部附属病院, 講師 (70324209)
TAGUCHI Mitsumasa 独立行政法人日本原子力研究開発機構, その他部局等, 研究員 (60343943)
HIROKI Akihiro 独立行政法人日本原子力研究開発機構, その他部局等, 研究員 (10370462)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | ハイドロゲル / 電子線 / 末梢神経障害 / 疼痛緩和 / 水溶性高分子 / 緩和医療 / ガンマ線 / ポリエチレンオキサイド / カラギーナン |
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| Research Abstract |
Peripheral neuropathy is a harmful adverse drug reaction induced by high and multiple dosing of cytotoxic drugs. In this study, we focused on the hydrogel as an alternative for the oral administration.
The goal of this study was to investigate the physicochemical properties of hydrogel prepared by electron beam irradiation and the feasibility as a drug carrier. Aqueous solution of 10 or 20 wt% methylcellulose, hydroxypropylcellulose or hydroxypropyl methylcellulose were irradiated to a dose of 10 to 50 kGy to obtain gels.
Gel fraction of each sample increased with increase in the dose. In contrast, the degree of swelling decreased with increase in the dose. Gel strength of hydrogels was improved with increasing polymer content and the dose. From these results, the hydrogels could be obtained by the electron beam radiation, and it seemed to be feasible as a drug carrier.
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