Establish the optimal method of administration of the antimicrobial agent was used as an index of treatment goal probability of achieving the target organ and PK / PD theory

• Project/Area Number: 23590184
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Hiroshima University
• Principal Investigator: MORIKAWA Norifumi 広島大学, 医歯薬保健学研究院(薬), 教授 (30346481)
• Co-Investigator(Kenkyū-buntansha): IKAWA Kazuro 広島大学, 大学院医歯薬保健学研究院 (薬), 准教授 (40363048) ; IKEDA Kayo 広島大学, 大学院医歯薬保健学研究院 (薬), 助教 (30379911)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 薬物動態 / 抗菌剤 / ＰＫ／ＰＤ理論 / 医療系薬学 / 日本 / 臨床 / 感染症 / PK/PD

Research Abstract

We reported the determination of doripenem and meropenem penetration into human prostate tissue and assessment of dosing regimens for prostatitis based on site-specific pharmacokinetic pharmacodynamic evaluation. We reported the optimisation of imipenem regimens in patients with impaired renal function by pharmacokinetic pharmacodynamic target attainment analysis of plasma and urinary concentration data. We reported the clinical pharmacokinetics and pharmacodynamics of clarithromycin and telithromycin in epithelial lining fluid of the bronchi.

Research Products

• [Journal Article] Clinical pharmacokinetics of meropenem in pancreatic juice and site-specific pharmacodynamic target attainment against Gram-negative bacteria : dosing considerations (2014)
  • Author(s): Kondo N, Ikawa K, Murakami Y, Uemura K, Sudo T, Hashimoto Y, Ohge H, Morikawa N, Sueda T
  • Journal Title: Pancreatology Volume: 14
  • Peer Reviewed
• [Journal Article] Evaluation of the efficacy and safety of biapenem against pneumonia in the elderly and a study on its pharmacokinetics (2013)
  • Author(s): Karino F, Deguchi N, Kanda H, Ohe M, Kondo K, Tada M, Kuraki T, Nishimura N, Moriyama H, Ikawa K, Morikawa N, Isobe T
  • Journal Title: J. Infect. Chemother Volume: 19
  • NAID: 10031155825
  • Peer Reviewed
• [Journal Article] Prostatic penetration of meropenem in humans, and dosage considerations for prostatitis based on a site-specific pharmacokinetic/ pharmacodynamic evaluation (2013)
  • Author(s): Nishikawa G, Ikawa K, Nakamura K, Yamada Y, Zennami K, Mitsui K, Narushima M, Ikeda K, Morikawa N, Sumitomo M
  • Journal Title: Int. J. Antimicrob. Agents Volume: 41
  • Peer Reviewed
• [Journal Article] Penetration of meropenem into human pancreatic juice (2013)
  • Author(s): Ikawa K, Kondo N, Nakashima A, Yoshizawa K, Morikawa N, Ikeda K, Murakami Y, Ohge H, Sueda T
  • Journal Title: Scand. J. Infect. Dis Volume: 45
  • Peer Reviewed
• [Journal Article] Development of initial loading procedure for teicoplanin in critically ill patients with severe infections (2013)
  • Author(s): Matsumoto K, Kanazawa N, Watanabe E, Yokoyama Y, Fukamizu T, Shimodozono Y, Maeda C, Yasuda T, Kakihana Y, Ikawa K, Morikawa N, Takeda Y
  • Journal Title: Biol. Pharm. Bull Volume: 36
  • NAID: 130003361437
  • Peer Reviewed
• [Journal Article] Population pharmacokinetic-pharmacodynamic target attainment analysis of imipenem plasma and urine data in neonates and children (2013)
  • Author(s): Yoshizawa K, Ikawa K, Ikeda K, Ohge H, Morikawa N
  • Journal Title: Pediatr. Infect. Dis. J Volume: 32
  • Peer Reviewed
• [Journal Article] Prostatic penetration of meropenem in humans, and dosage considerations for prostatitis based on a site-specific pharmacokinetic/pharmacodynamic evaluation. (2013)
  • Author(s): Nishikawa G, Ikawa K, Nakamura K, Yamada Y, Zennami K, Mitsui K, Narushima M, Ikeda K, Morikawa N, Sumitomo M.
  • Journal Title: Int. J. Antimicrob. Agents Volume: 41 Pages: 267-271
  • Peer Reviewed
• [Journal Article] Penetration of meropenem into human pancreatic juice. (2013)
  • Author(s): Ikawa K, Kondo N, Nakashima A, Yoshizawa K, Morikawa N, Ikeda K, Murakami Y, Ohge H, Sueda T.
  • Journal Title: Scand. J. Infect. Dis. Volume: 45 Pages: 404-406
  • Peer Reviewed
• [Journal Article] Population pharmacokinetic-pharmacodynamic target attainment analysis of imipenem plasma and urine data in neonates and children. (2013)
  • Author(s): Yoshizawa K, Ikawa K, Ikeda K, Ohge H, Morikawa N.
  • Journal Title: Pediatr. Infect. Dis. J. Volume: 32 Pages: 1208-1216
  • Peer Reviewed
• [Journal Article] Determination of doripenem penetration into human prostate tissue and assessment of dosing regimens for prostatitis based on site-specific pharmacokinetic-pharmacodynamic evaluation (2012)
  • Author(s): Nakamura K, Ikawa K, Yamada Y, Arakawa M, Zennami K, Nishikawa G, Ikeda K, Morikawa N, Honda N
  • Journal Title: J. Chemother Volume: 24
  • Peer Reviewed
• [Journal Article] Reduction in the incidence of MRSA with use of alcohol-based hand rub solutions and gloves (2012)
  • Author(s): Matsumoto K, Shigemi A, Yaji K, Shimodozono Y, Takeda Y, Ikawa K, Morikawa N, Miyanohara H, Kawamura H, Orita M, Tokuda K, Nishi J, Yamada K
  • Journal Title: J. Infect. Chemother Volume: 18
  • NAID: 10030545826
  • Peer Reviewed
• [Journal Article] Optimisation of imipenem regimens in patients with impaired renal function by pharmacokinetic-pharmacodynamic target attainment analysis of plasma and urinary concentration data (2012)
  • Author(s): Yoshizawa K, Ikawa K, Ikeda K, Kumon H, Ohge H, Morikawa N
  • Journal Title: Int. J. Antimicrob. Agents Volume: 40
  • Peer Reviewed
• [Journal Article] Pharmacokinetics of ampicillin-sulbactam and the renal function-based optimization of dosing regimens for prophylaxis in patients undergoing cardiovascular surgery (2012)
  • Author(s): Yokoyama Y, Matsumoto K, Yamamoto H, Iguro Y, Imoto Y, Ikawa K, Morikawa N, Ishida S, Okano Y, Watanabe E, Shimodozono Y, Yamada K, Takeda Y
  • Journal Title: J. Infect. Chemother Volume: 18
  • NAID: 10031143890
  • Peer Reviewed
• [Journal Article] Determination of doripenem penetration into human prostate tissue and assessment of dosing regimens for prostatitis based on site-specific pharmacokinetic-pharmacodynamic evaluation. (2012)
  • Author(s): Nakamura K, Ikawa K, Yamada Y, Arakawa M, Zennami K, Nishikawa G, Ikeda K, Morikawa N, Honda N.
  • Journal Title: Journal of Chemotherapy Volume: 24 Pages: 32-37
  • Peer Reviewed
• [Journal Article] Optimisation of imipenem regimens in patients with impaired renal function by pharmacokinetic-pharmacodynamic target attainment analysis of plasma and urinary concentration data. (2012)
  • Author(s): Yoshizawa K, Ikawa K, Ikeda K, Kumon H, Ohge H, Morikawa N.
  • Journal Title: Int J Antimicrob Agents. Volume: 40 Pages: 427-433
  • Peer Reviewed
• [Journal Article] Reduction in the incidence of MRSA with use of alcohol-based hand rub solutions and gloves. (2012)
  • Author(s): Matsumoto K, Shigemi A, Yaji K, Shimodozono Y, Takeda Y, Ikawa K, Morikawa N, Miyanohara H, Kawamura H, Orita M, Tokuda K, Nishi J, Yamada K.
  • Journal Title: J Infect Chemother. Volume: 18 Pages: 269-271
  • NAID: 10030545826
  • Peer Reviewed
• [Journal Article] Prostatic Penetration of Meropenem after intravenous Administration in patients Undergoing Transurethral Resection of the Prostate (2011)
  • Author(s): Y.Yamada,K.Ikawa, K.Nakamura,K.Mitsui, M.Nakamura, H.Hibi, K.Ikeda, N.Morikawa, N.Honda
  • Journal Title: Journal of Chemotherapy Volume: 23 Pages: 179-180
  • Peer Reviewed
• [Journal Article] Safety analysis of liposomal amphotericin B in adult patients: anaemia, thrombocytopenia, nephrotoxicity, hepatotoxicity and hypokalaemia. (2011)
  • Author(s): Shigemi A, Matsumoto K, Ikawa K, Yaji K, Shimodozono Y, Morikawa N, Takeda Y, Yamada K
  • Journal Title: Int J Antimicrob Agents. Volume: 38 Pages: 417-420
  • Peer Reviewed
• [Journal Article] An initial dosing method for teicoplanin based on the area under the serum concentration time curve required for MRSA eradication. (2011)
  • Author(s): Kanazawa N, Matsumoto K, Ikawa K, Fukamizu T, Shigemi A, Yaji K, Shimodozono Y, Morikawa N, Takeda Y, Yamada K.
  • Journal Title: J Infect Chemother. Volume: 17 Pages: 297-300
  • NAID: 10028171743
  • Peer Reviewed
• [Presentation] Evaluation of predictive pharmacokinetic-pharmacodynamic software coupled with Bayesian method for carbapenem therapy in patients with pneumonia (2013)
  • Author(s): Ishihara N, Nishimura N, Karino F, Miura K, Isobe T, Ikawa K, Morikawa N, Naora K
  • Organizer: 73rd International Pharmaceutical Federation World Congress of Pharmacy and Pharmaceutical Sciences
  • Place of Presentation: Dublin, Ireland
• [Presentation] Clinical pharmacokinetics of doripenem and meropenem in prostate tissue, and dosing considerations for prostatitis based on site-specific pharmacodynamic target attainment (2013)
  • Author(s): Ikawa K, Nakamura K, Nishikawa G, Yamada Y, Zennami K, Mitsui K, Narushima M, Ikeda K, Morikawa N, Sumitomo M
  • Organizer: 13th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology
  • Place of Presentation: Salt Lake City, USA
• [Presentation] Pharmacokinetics and pharmacodynamics of biapenem in patients with bacterial pyelonephritis (2013)
  • Author(s): Wada K, Yamamoto M, Mitsuhata R, Sako S, Ishii A, Kariyama R, Watanabe T, Ikawa K, Morikawa N, Kumon H
  • Organizer: 28th International Congress of Chemotherapy & 14th Asia-Pacific Congress of Clinical Microbiology and Infection
  • Place of Presentation: Yokohama, Japan
• [Presentation] Pharmacodynamics, pharmacokinetics of piperacillin/tazobactam in Japanese elderly patients with nursing and healthcare-associated pneumonia (2013)
  • Author(s): Nishimura N, Karino F, Ishihara N, Moriyama H, Miura K, Sutani A, Kuraki T, Ikawa K, Morikawa N, Naora K, Isobe T
  • Organizer: 28th International Congress of Chemotherapy & 14th Asia-Pacific Congress of Clinical Microbiology and Infection
  • Place of Presentation: Yokohama, Japan
• [Presentation] Biliary pharmacokinetics and pharmacodynamic target attainment of intravenous pazufloxacin in surgery patients (2013)
  • Author(s): Uegami S, Ohge H, Ikawa K, Shigemoto N, Nakashima A, Ikeda K, Morikawa N, Sueda T
  • Organizer: 28th International Congress of Chemotherapy & 14th Asia-Pacific Congress of Clinical Microbiology and Infection
  • Place of Presentation: Yokohama, Japan
• [Presentation] Pharmacokinetic and pharmacodynamic evaluation of sulbactam against Acinetobacter baumannii in a murine thigh infection model (2013)
  • Author(s): Yokoyama Y, Matsumoto K, Watanabe E, Shigemi A, Umezaki Y, Takeshita A, Nakamura K, Okuno M, Ikawa K, Morikawa N, Takeda Y
  • Organizer: 28th International Congress of Chemotherapy & 14th Asia-Pacific Congress of Clinical Microbiology and Infection
  • Place of Presentation: Yokohama, Japan
• [Presentation] Prostatic penetration of meropenem in humans, and dosage considerations for prostatitis based on site-specific pharmacokinetic-pharmacodynamic evaluation (2013)
  • Author(s): Nishikawa G, Ikawa K, Nakamura K, Yamada Y, Zennami K, Ikeda K, Morikawa N, Sumitomo M
  • Organizer: 28th Annual Congress of the European Association of Urology
  • Place of Presentation: Milan, Italy
• [Presentation] Clinical pharmacokinetics of doripenem and meropenem in prostate tissue, and dosing considerations for prostatitis based on site-specific pharmacodynamic target attainment. (2013)
  • Author(s): Ikawa K, Nakamura K, Nishikawa G, Yamada Y, Zennami K, Mitsui K, Narushima M, Ikeda K, Morikawa N, Sumitomo M.
  • Organizer: 13th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology
  • Place of Presentation: Salt Lake City, USA
• [Presentation] Prostatic penetration of meropenem in humans, and dosage considerations for prostatitis based on site-specific pharmacokinetic- pharmacodynamic evaluation (2012)
  • Author(s): Nishikawa G, Ikawa K, Nakamura K, Yamada Y, Zennami K, Morikawa N, Sumitomo M
  • Organizer: 32nd Congress of the Société Internationale d'Urologie
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Clinical pharmacokinetics and pharmacodynamics of clarithromycin and telithromycin in epithelial lining fluid of the bronchi (2012)
  • Author(s): Ikawa K, Kikuchi E, Kikuchi J, Nishimura M, Derendorf H, Morikawa N
  • Organizer: 41st Annual Meeting of the American College of Clinical Pharmacology
  • Place of Presentation: San Diego, USA
• [Presentation] Pharmacokinetic modeling of cefepime concentration data in human lung and target-organ-specific pharmacodynamic simulation (2012)
  • Author(s): Ikawa K, Iida S, Morikawa N
  • Organizer: 1st World Conference on Pharmacometrics
  • Place of Presentation: Seoul, Korea
• [Presentation] Determination of doripenem penetration into human prostate tissue and assessment of dosing regimens for prostatitis based on site-specific pharmacokinetic- pharmacodynamic evaluation (2012)
  • Author(s): Nakamura K, Ikawa K, Yamada Y, Nishikawa G, Zennami K, Morikawa N, Sumitomo M
  • Organizer: 27th Annual Congress of the European Association of Urology
  • Place of Presentation: Paris, France
• [Presentation] Clinical pharmacokinetics and pharmacodynamics of clarithromycin and telithromycin in epithelial lining fluid of the bronchi. (2012)
  • Author(s): Ikawa K, Kikuchi E, Kikuchi J, Nishimura M, Derendorf H, Morikawa N.
  • Organizer: 41st Annual Meeting of the American College of Clinical Pharmacology 2012.
  • Place of Presentation: San Diego, USA