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Anti-tumor effect of macrolide antibiotics on MALT lymphoma

Research Project

Project/Area Number 23590188
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical pharmacy
Research InstitutionNagasaki University

Principal Investigator

ISHIMATSU Yuji  長崎大学, 医歯薬学総合研究科(保健学科), 教授 (40533899)

Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
KeywordsMALTリンパ腫 / マクロライド系抗菌薬 / アポトーシス / Helicobacter pylori / Bcl-xL / NF-κB
Outline of Final Research Achievements

This study was aimed at determining whether macrolide antibiotics (MCL) have a direct anti-tumor effect on mucosa-associated lymphoid tissue (MALT) lymphoma. Gastric and pulmonary MALT lymphomas were immunohistochemically examined for Bcl-xL (apoptosis regulator) expression. Patients with a good clinical course after MCL administration showed high Bcl-xL expression, whereas those with a poor response to MCL showed no or very faint Bcl-xL expression. The results of this study suggest that the direct anti-tumor effect of MCL on MALT lymphoma could be predicted by Bcl-xL expression.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (3 results)

All Other

All Presentation (3 results)

  • [Presentation] クラリスロマイシン耐性化後15員環マクロライド系抗菌薬が有効であった肺MALTリンパ腫の1例

    • Author(s)
      原田達彦、原敦子、石松祐二、朝長正臣、中島章太、原信太郎、角川智之、坂本憲穂、河野茂
    • Organizer
      第15回長崎マクロライド研究会
    • Place of Presentation
      ホテルニュー長崎(長崎市)
    • Related Report
      2013 Research-status Report
  • [Presentation] The effect of macrolide antibiotics on co-infection of influenza virus and Streptococcus pneumoniae in mice.

    • Author(s)
      Tatsuhiko Harada, Towako Morita, Atsuko Hara, Shota Nakashima, Shintaro Hara, Tomoyuki Kakugawa, Hanako Fujita, Noriho Sakamoto, Yuji Ishimatsu and Shigeru Kohno
    • Organizer
      American Thoracic Society International Conference 2013
    • Place of Presentation
      Pennsylvania convention center (Philadelphia, America)
    • Related Report
      2013 Research-status Report
  • [Presentation] Myeloperoxidase Anti-Neutrophil Cytoplasmic Antibody (MPO-ANCA) Associated Lung Disease: Clinical, Radiological And Bronchoalveolar Lavage Fluid Findings

    • Author(s)
      Takuto Miyamura, Shota Nakashima, Yuji Ishimatsu, Masaomi Tomonaga, Tatsuhiko Harada, Shintaro Hara, Tomoyuki Kakugawa, Noriho Sakamoto, Katsunori Yanagihara and Shigeru Kohno
    • Organizer
      第18回アジア太平洋呼吸器学会 (APSR 2013)
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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