Anti-tumor effect of macrolide antibiotics on MALT lymphoma

• Project/Area Number: 23590188
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Nagasaki University
• Principal Investigator: ISHIMATSU Yuji 長崎大学, 医歯薬学総合研究科(保健学科), 教授 (40533899)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: MALTリンパ腫 / マクロライド系抗菌薬 / アポトーシス / Helicobacter pylori / Bcl-xL / NF-κB

Outline of Final Research Achievements

This study was aimed at determining whether macrolide antibiotics (MCL) have a direct anti-tumor effect on mucosa-associated lymphoid tissue (MALT) lymphoma. Gastric and pulmonary MALT lymphomas were immunohistochemically examined for Bcl-xL (apoptosis regulator) expression. Patients with a good clinical course after MCL administration showed high Bcl-xL expression, whereas those with a poor response to MCL showed no or very faint Bcl-xL expression. The results of this study suggest that the direct anti-tumor effect of MCL on MALT lymphoma could be predicted by Bcl-xL expression.

Research Products

• [Presentation] クラリスロマイシン耐性化後15員環マクロライド系抗菌薬が有効であった肺MALTリンパ腫の1例
  • Author(s): 原田達彦、原敦子、石松祐二、朝長正臣、中島章太、原信太郎、角川智之、坂本憲穂、河野茂
  • Organizer: 第15回長崎マクロライド研究会
  • Place of Presentation: ホテルニュー長崎（長崎市）
• [Presentation] The effect of macrolide antibiotics on co-infection of influenza virus and Streptococcus pneumoniae in mice.
  • Author(s): Tatsuhiko Harada, Towako Morita, Atsuko Hara, Shota Nakashima, Shintaro Hara, Tomoyuki Kakugawa, Hanako Fujita, Noriho Sakamoto, Yuji Ishimatsu and Shigeru Kohno
  • Organizer: American Thoracic Society International Conference 2013
  • Place of Presentation: Pennsylvania convention center (Philadelphia, America)
• [Presentation] Myeloperoxidase Anti-Neutrophil Cytoplasmic Antibody (MPO-ANCA) Associated Lung Disease: Clinical, Radiological And Bronchoalveolar Lavage Fluid Findings
  • Author(s): Takuto Miyamura, Shota Nakashima, Yuji Ishimatsu, Masaomi Tomonaga, Tatsuhiko Harada, Shintaro Hara, Tomoyuki Kakugawa, Noriho Sakamoto, Katsunori Yanagihara and Shigeru Kohno
  • Organizer: 第18回アジア太平洋呼吸器学会 (APSR 2013)
  • Place of Presentation: パシフィコ横浜（横浜市）