Anti-tumor effect of macrolide antibiotics on MALT lymphoma
| Project/Area Number |
23590188
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Nagasaki University |
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Principal Investigator |
ISHIMATSU Yuji 長崎大学, 医歯薬学総合研究科(保健学科), 教授 (40533899)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | MALTリンパ腫 / マクロライド系抗菌薬 / アポトーシス / Helicobacter pylori / Bcl-xL / NF-κB |
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| Outline of Final Research Achievements |
This study was aimed at determining whether macrolide antibiotics (MCL) have a direct anti-tumor effect on mucosa-associated lymphoid tissue (MALT) lymphoma. Gastric and pulmonary MALT lymphomas were immunohistochemically examined for Bcl-xL (apoptosis regulator) expression. Patients with a good clinical course after MCL administration showed high Bcl-xL expression, whereas those with a poor response to MCL showed no or very faint Bcl-xL expression. The results of this study suggest that the direct anti-tumor effect of MCL on MALT lymphoma could be predicted by Bcl-xL expression.
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Report
(5 results)
Research Products
(3 results)
