| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
This study was aimed to investigate the relation between the regulation of NO-cGMP system by the endogenous NO synthase inhibitor ADMA and peripheral circadian clock in pancreatic beta-cells and the involvement of these systems in the pathogenesis of diabetes. We found that the expression of the ADMA metabolic enzyme DDAH2 in beta-cells is suppressed by high glucose, suggesting that the NO-cGMP system is down-regulated by the accumulation of ADMA in diabetes. Unfortunately, we could not obtain any evidence for a relation between the NO-cGMP system and peripheral circadian clock in beta-cells. On the other hand, melatonin, a circadian synchronizer, was suggested to inhibit insulin secretion from beta-cells in the presence of GLP-1 secreted from the gastrointestinal mucosa in response to a meal. Thus, the possibility is raised that some relation between food intake and circadian rhythm exists in the regulation of beta-cell functions.
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