| Project/Area Number |
23590193
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
KIKUCHI CHIGUSA 名古屋市立大学, 薬学研究科(研究院), 講師 (20444987)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUNAGA Tamihide 名古屋市立大学, 大学院薬学研究科, 教授 (40209581)
IMAEDA Kenro 名古屋市立大学, 大学院医学研究科, 講師 (30347398)
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Tadashi 名古屋市立大学, 大学院薬学研究科, 教授 (20555081)
KAJIKURI Jyunko 名古屋市立大学, 大学院医学研究科, 研究員 (10444986)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 糖尿病 / 血管障害 / 活性酸素 / 食後高血糖 / DPP-4阻害薬 / スーパーオキシド / protein kinase C / eNOS |
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| Research Abstract |
In this study, we examined the mechanism of vascular dysfunction mediated by postprandial hyperglycemia and the effects of new antidiabetes agent, dipeptidyl peptidase 4 (DPP-4) inhibitor using model animals and patient's data. Onset of atherosclerotic disease in diabetic patients was depend on circadian rhythm of blood glucose. Protein kinase C delta was decreased and reactive oxygen species via eNOS uncoupling was increased in the vascular wall of postprandial hyperglycemia model animals. Chronic administration of DPP-4 inhibitor suppresses postprandial hyperglycemia and decreased reactive oxygen species production.
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