Biopharmaceutical Study on Organic Solute Transporters Which Modulate Central Nervous System
| Project/Area Number |
23590206
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
守屋 友加 名城大学, 薬学部, 助教 (00512295)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | トランスポーター / 中枢神経系 / 神経伝達物質 / 再取り込み / アストロサイト / TCA回路中間体 / 大脳皮質初代培養ニューロン / ジペプチドトランスポーター / ジ・トリカルボン酸トランスポーター / ニューロペプチド / 初代培養神経 |
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| Research Abstract |
In vivo fate of amino acids and neurotransmitters in brain is precisely regulated by release from neuron and/or astrocytes and by their re-uptake, and is responsible for maintenance of brain high-order function. In this study, we investigated the functional characterization of N-acetyl-L-aspartyl-L-glutamate (NAAG) and carnitine transporter in mouse preimarily cultured neurons and astrocytes. NAAG was found to be taken up by oligopeptide transporter (PEPT) 2 in astrocytes. In addition, carnitine was found to be taken up by GABA transporter (GAT) 1 and carnitine/organic cation transporter (OCTN) 2 in neuron.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Pharmacokinetic interaction study of sulfasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP2012
Author(s)
Hiroyuki Kusuhara, Hidetoshi Furuie, Akihiro Inano, Akihiro Sunagawa, Sakiko Yamada, Chungyong Wu, Shinya Fukizawa, Ichiro Ieiri, Mariko Morishita, Kiminobu Sumida, Hiroshi Mayahara, Takuya Fujita, Kazuya Maeda, and Yuichi Sugiyama
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Journal Title
Br. J. Pharmacol
Volume: 166 (6)
Pages: 1793-1803
Related Report
Peer Reviewed
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