Development of the effective ophthalmic formulations that simultaneously targeting intraocular pressure and optic nerve
| Project/Area Number |
23590208
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAGAI Noriaki 近畿大学, 薬学部, 講師 (90411579)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | ピログルタミン酸 / 緑内障 / シクロデキストリン / 眼圧 / 視神経 / 一酸化窒素 / 眼瞼適用ゲルパッチ / 網膜 / 点眼薬 / 角膜傷害 / アセチルコチン / シュレム管 |
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| Research Abstract |
We demonstrated that the treatment of L-pyroglutamic acid decreased the enhanced intraocular pressure, and enhanced the survival of retinal ganglion cells after optic nerve transection in the in vivo study. In addition, we tried to develop the transdermal drug delivery system for ophthalmic therapy. It is possible that the transdermal ophthalmic therapy by using L-pyroglutamic acid provide the effective therapy for glaucoma patient.
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Report
(4 results)
Research Products
(9 results)
