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Development of the effective ophthalmic formulations that simultaneously targeting intraocular pressure and optic nerve

Research Project

Project/Area Number 23590208
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical pharmacy
Research InstitutionKinki University

Principal Investigator

ITO Yoshimasa  近畿大学, 薬学部, 准教授 (50128633)

Co-Investigator(Renkei-kenkyūsha) NAGAI Noriaki  近畿大学, 薬学部, 講師 (90411579)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Keywordsピログルタミン酸 / 緑内障 / シクロデキストリン / 眼圧 / 視神経 / 一酸化窒素 / 眼瞼適用ゲルパッチ / 網膜 / 点眼薬 / 角膜傷害 / アセチルコチン / シュレム管
Research Abstract

We demonstrated that the treatment of L-pyroglutamic acid decreased the enhanced intraocular pressure, and enhanced the survival of retinal ganglion cells after optic nerve transection in the in vivo study. In addition, we tried to develop the transdermal drug delivery system for ophthalmic therapy. It is possible that the transdermal ophthalmic therapy by using L-pyroglutamic acid provide the effective therapy for glaucoma patient.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (9 results)

All 2014 2013 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (2 results) Remarks (4 results)

  • [Journal Article] Reduction of Enhanced Rabbit Intraocular Pressure by Instillation of Pyroglutamic Acid Eye Drops2013

    • Author(s)
      Ito Y., Nagai N., Okamoto N., Shimomura Y., Nakanishi K., Tanaka R
    • Journal Title

      Biol. Pharm. Bull

      Volume: 36 (Highlighted paper selected by Editor-in-Chief) Pages: 1017-1023

    • NAID

      130003361452

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduction of Enhanced Rabbit Intraocular Pressure by Instillation of Pyroglutamic Acid Eye Drops2013

    • Author(s)
      Ito Yoshimasa, Nagai Noriaki
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 36 Issue: 6 Pages: 1017-1023

    • DOI

      10.1248/bpb.b13-00159

    • NAID

      130003361452

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduction of Enhanced Rabbit Intraocular Pressure by Instillation of Pyroglutamic Acid Eye Drops2013

    • Author(s)
      Ito Yoshimasa
    • Journal Title

      Biological & Pharmaceutical Bulletin

      Volume: -

    • NAID

      130003361452

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] ナノ化技術を応用した眼瞼適用ゲルパッチ「貼るめぐすり」の開発とその有効性2014

    • Author(s)
      吉岡千晶,長井紀章,伊藤吉將,高橋秀也,志水英二,松井誠,守本英二
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Final Research Report
  • [Presentation] ナノ化技術を応用した眼瞼適用ゲルパッチ「貼るめぐすり」の開発とその有効性2014

    • Author(s)
      伊藤 吉將,吉岡 千晶
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本市総合体育館,熊本県
    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.phar.kindai.ac.jp/pharmtec/

    • Related Report
      2013 Final Research Report
  • [Remarks] 近畿大学薬学部 製剤学研究室

    • URL

      http://www.phar.kindai.ac.jp/pharmtec/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 近畿大学薬学部 製剤学研究室

    • URL

      http://www.phar.kindai.ac.jp/pharmtec/

    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.phar.kindai.ac.jp/pharmtec/

    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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